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Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.
Myra Hosmillo, Jia Lu, Michael R McAllaster, James B Eaglesham, Xinjie Wang, Edward Emmott, Patricia Domingues, Yasmin Chaudhry, Tim J Fitzmaurice, Matthew Kh Tung, Marc Dominik Panas, Gerald McInerney, Nicolas Locker, Craig B Wilen, Ian G Goodfellow
Aug 20, 2019
Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication...
CRISPR G3BP1 Norovirus infectious disease microbiology stress granule Translation Virus Animals Caliciviridae Infections Cell Line DNA Helicases Host-Pathogen Interactions Humans Mice Norovirus Poly-ADP-Ribose Binding Proteins Protein Biosynthesis RNA Helicases RNA Recognition Motif Proteins Viral Proteins