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Cover Image for LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation View Article
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
M Raab, Y Lu, K Kohler, X Smith, K Strebhardt, CE Rudd
Jul 24, 2017
Adaptor Proteins Signal Transducing Cell Cycle Proteins Dendritic Cells Focal Adhesion Kinase 1 Focal Adhesion Kinase 2 GRB2 Adaptor Protein Humans Jurkat Cells Lymphocyte Function-Associated Antigen-1 Membrane Proteins Microtubule-Associated Proteins Phosphoproteins Phosphorylation T-Lymphocytes
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Cover Image for Grb2 binding induces phosphorylation-independent activation of Shp2. View Article
Grb2 binding induces phosphorylation-independent activation of Shp2.
Chi-Chuan Lin, Lukasz Wieteska, Kin Man Suen, Arnout P Kalverda, Zamal Ahmed, John E Ladbury
Apr 01, 2021
The regulation of phosphatase activity is fundamental to the control of intracellular signalling and in particular the tyrosine kinase-mediated mitogen-activated protein kinase (MAPK) pathway. Shp2 is a ubiquitously expressed...
Enzyme Activation GRB2 Adaptor Protein Phosphorylation Protein Tyrosine Phosphatase Non-Receptor Type 11 Signal Transduction
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