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Results: 8
Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.
Ximena Ibarra-Soria, Wajid Jawaid, Blanca Pijuan-Sala, Vasileios Ladopoulos, Antonio Scialdone, David J Jörg, Richard CV Tyser, Fernando J Calero-Nieto, Carla Mulas, Jennifer Nichols, Ludovic Vallier, Shankar Srinivas, Benjamin D Simons, Berthold Göttgens, John C Marioni
Feb 02, 2018
During gastrulation, cell types from all three germ layers are specified and the basic body plan is established 1 . However, molecular analysis of this key developmental stage has been hampered by limited cell numbers and a...
Claire M Lye, Guy B Blanchard, Huw W Naylor, Leila Muresan, Jan Huisken, Richard J Adams, Bénédicte Sanson
Oct 07, 2015
Animals Biomarkers Cell Shape Cell Size Drosophila Drosophila Proteins Embryo Nonmammalian Endoderm Gastrulation Green Fluorescent Proteins Mechanical Phenomena Membrane Fusion Proteins Microscopy Electron Scanning Microscopy Video Models Anatomic Morphogenesis Mutation Recombinant Fusion Proteins Rheology Time-Lapse Imaging Twist-Related Protein 1
A single-cell molecular map of mouse gastrulation and early organogenesis.
Blanca Pijuan-Sala, Jonathan A Griffiths, Carolina Guibentif, Tom W Hiscock, Wajid Jawaid, Fernando J Calero-Nieto, Carla Mulas, Ximena Ibarra-Soria, Richard CV Tyser, Debbie Lee Lian Ho, Wolf Reik, Shankar Srinivas, Benjamin D Simons, Jennifer Nichols, John C Marioni, Berthold Göttgens
Jan 30, 2019
Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult organism. Here we report the...
Animals Cell Differentiation Cell Lineage Chimera Embryo Mammalian Endoderm Endothelium Female Gastrulation Gene Expression Profiling Gene Expression Regulation Developmental Hematopoiesis Male Mesoderm Mice Mutation Myeloid Cells Organogenesis Pluripotent Stem Cells Primitive Streak Single-Cell Analysis T-Cell Acute Lymphocytic Leukemia Protein 1
Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis
Apr 11, 2018
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on...
Decoding the regulatory network of early blood development from single-cell gene expression measurements.
Victoria Moignard, Steven Woodhouse, Laleh Haghverdi, Andrew J Lilly, Yosuke Tanaka, Adam C Wilkinson, Florian Buettner, Iain C Macaulay, Wajid Jawaid, Evangelia Diamanti, Shin-Ichi Nishikawa, Nir Piterman, Valerie Kouskoff, Fabian J Theis, Jasmin Fisher, Berthold Göttgens
Apr 02, 2015
Multi-omics profiling of mouse gastrulation at single-cell resolution.
Ricard Argelaguet, Stephen J Clark, Hisham Mohammed, L Carine Stapel, Christel Krueger, Chantriolnt-Andreas Kapourani, Ivan Imaz-Rosshandler, Tim Lohoff, Yunlong Xiang, Courtney W Hanna, Sebastien Smallwood, Ximena Ibarra-Soria, Florian Buettner, Guido Sanguinetti, Wei Xie, Felix Krueger, Berthold Göttgens, Peter J Rugg-Gunn, Gavin Kelsey, Wendy Dean, Jennifer Nichols, Oliver Stegle, John C Marioni, Wolf Reik
Oct 29, 2019
Animals Cell Differentiation Cell Lineage Chromatin DNA Methylation Demethylation Embryoid Bodies Endoderm Enhancer Elements Genetic Epigenesis Genetic epigenome Erythropoiesis Factor Analysis Statistical Gastrula Gastrulation Gene Expression Regulation Developmental Mesoderm Mice Pluripotent Stem Cells RNA Single-Cell Analysis Time Factors Zinc Fingers
Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation
H Mohammed, I Hernando-Herraez, A Savino, A Scialdone, I Macaulay, C Mulas, T Chandra, T Voet, W Dean, J Nichols, JC Marioni, W Reik
Sep 25, 2017