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Results: 411
Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions.
Carol A Edwards, William MD Watkinson, Stephanie B Telerman, Lisa C Hulsmann, Russell S Hamilton, Anne C Ferguson-Smith
Apr 12, 2023
James Darnell, Jr., 1973
The Rockefeller University
Jan 01, 0001
James E. Darnell, Jr. The origins of mRNA and the structure of the mammalian chromosome
Lecture delivered September 20, 1973
Posted with permission
Published by: Academic Press
The Effect of Immunosuppressive Agents on the Induction of Nuclear Factors that Bind to Sites on the Interleukin 2 Promoter
Cyclosporin A (CSA), FK506, and glucocorticosteroids all inhibit the production of lymphokines by decreasing lymphokine gene expression. Previous experiments have defined six different sites that may contribute to the...
Published by: Rockefeller University
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern....
Estrogen estrogen receptor MCF7 Breast Cancer Chromosomes Computational Biology endocrine Gene Expression human Systems Biology Base Sequence Binding Sites Estradiol Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genome Human Genome-Wide Association Study Humans MCF-7 Cells Neoplasm Proteins Promoter Regions Genetic Protein Binding Receptors CXCR Signal Transduction Sorting Nexins Trefoil Factor-1
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein
Michael D Crabtree, Wade Borcherds, Anusha Poosapati, Sarah L Shammas, Gary W Daughdrill, Jane Clarke
Mar 26, 2018
Appropriate integration of cellular signals requires a delicate balance of ligand-target binding affinities. Increasing the level of residual structure in intrinsically disordered proteins (IDPs), which are overrepresented in...
Amino Acid Sequence Animals Binding Sites Cloning Molecular Conserved Sequence Escherichia coli Gene Expression Histone-Lysine N-Methyltransferase Humans Intrinsically Disordered Proteins Membrane Proteins Mice Models Molecular Mutation Myeloid-Lymphoid Leukemia Protein Phosphoproteins Proline Protein Binding Protein Conformation alpha-Helical Protein Folding Protein Interaction Domains and Motifs Recombinant Proteins Sequence Alignment Sequence Homology Amino Acid Tumor Suppressor Protein p53
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne EM Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline CW Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Sep 05, 2018
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In...
ADAMTS Proteins Asian People Cornea Corneal Diseases Corneal Dystrophies Hereditary Decorin Ehlers-Danlos Syndrome Eye Diseases Hereditary Fibrillin-1 Gene Expression Genome Human Genome-Wide Association Study Glaucoma Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait Heritable Transforming Growth Factor beta2 White People
Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies.
Bilal Khalil, Marie-Jeanne Cabirol-Pol, Laetitia Miguel, Alexander J Whitworth, Magalie Lecourtois, Jean-Charles Liévens
Apr 05, 2019
ALS Dynamin-related protein 1 FTLD Mitochondria Mitochondrial Dynamics Animals DNA-Binding Proteins Disease Models Animal Drosophila Drosophila Proteins Dynamins Gene Expression Locomotion Membrane Proteins Mitochondria Mitochondrial Dynamics Molecular Targeted Therapy Neuromuscular Junction Neurons RNA Messenger TDP-43 Proteinopathies
Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.
Tom J Phillips, Hannah Scott, David A Menassa, Ashleigh L Bignell, Aman Sood, Jude S Morton, Takami Akagi, Koki Azuma, Mark F Rogers, Catherine E Gilmore, Gareth J Inman, Simon Grant, Yealin Chung, Mais M Aljunaidy, Christy-Lynn Cooke, Bruno R Steinkraus, Andrew Pocklington, Angela Logan, Gavin P Collett, Helena Kemp, Peter A Holmans, Michael P Murphy, Tudor A Fulga, Andrew M Coney, Mitsuru Akashi, Sandra T Davidge, C Patrick Case
Jun 18, 2018
Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes...
Structural and Functional Determinants of AC8 Trafficking, Targeting and Responsiveness in Lipid Raft Microdomains.
The fidelity of cAMP in controlling numerous cellular functions rests crucially on the precise organization of cAMP microdomains that are sustained by the scaffolding properties of adenylyl cyclase. Earlier studies suggested...
Adenylyl cyclase Caveolin Cholesterol Lipid rafts plasma membrane cAMP Adenylyl Cyclases Bacterial Proteins Brefeldin A Bridged Bicyclo Compounds Heterocyclic Caveolin 1 Cyclic AMP Cytoskeleton Gene Expression Genes Reporter Green Fluorescent Proteins Guanine Nucleotide Exchange Factors HEK293 Cells Humans Luminescent Proteins Membrane Microdomains Mutagenesis Site-Directed Protein Transport RNA Small Interfering Recombinant Fusion Proteins Thiazolidines beta-Cyclodextrins
Functional Alleles of Chicken BG Genes, Members of the Butyrophilin Gene Family, in Peripheral T Cells.
B-G B7 family Adaptive Immunity innate immunity Membrane Protein Alleles Alternative Splicing Amino Acid Sequence Animals Butyrophilins Chickens Cloning Molecular Exons Gene Expression Haplotypes Introns Models Molecular Multigene Family Phylogeny Protein Conformation Sequence Analysis DNA Structure-Activity Relationship T-Lymphocytes
modMine
Sergio Contrino, Richard N Smith, Daniela Butano, Adrian Carr, Fengyuan Hu, Rachel Lyne, Kim Rutherford, Alex Kalderimis, Julie Sullivan, Seth Carbon, Ellen T Kephart, Paul Lloyd, EO Stinson, Nicole L Washington, Marc D Perry, Peter Ruzanov, Zheng Zha, Suzanna E Lewis, Lincoln D Stein, Gos Micklem
Aug 01, 2018
In an effort to comprehensively characterize the functional elements within the genomes of the important model organisms Drosophila melanogaster and Caenorhabditis elegans, the NHGRI model organism Encyclopaedia of DNA Elements...
Immunoseq
A Morin, T Kwan, B Ge, L Letourneau, M Ban, K Tandre, M Caron, JK Sandling, J Carlsson, G Bourque, C Laprise, A Montpetit, A-C Syvanen, L Ronnblom, SJ Sawcer, MG Lathrop, T Pastinen
Feb 13, 2017
Overexpression of the Cytokine BAFF and Autoimmunity Risk
M Steri, V Orrù, ML Idda, M Pitzalis, M Pala, I Zara, C Sidore, V Faà, M Floris, M Deiana, I Asunis, E Porcu, A Mulas, MG Piras, M Lobina, S Lai, M Marongiu, V Serra, M Marongiu, G Sole, F Busonero, A Maschio, R Cusano, G Cuccuru, F Deidda, F Poddie, G Farina, M Dei, F Virdis, S Olla, MA Satta, M Pani, A Delitala, E Cocco, J Frau, G Coghe, L Lorefice, G Fenu, P Ferrigno, M Ban, N Barizzone, M Leone, FR Guerini, M Piga, D Firinu, I Kockum, I Lima Bomfim, T Olsson, L Alfredsson, A Suarez, PE Carreira, MJ Castillo-Palma, JH Marcus, M Congia, A Angius, M Melis, A Gonzalez, ME Alarcón Riquelme, BM da Silva, M Marchini, MG Danieli, S Del Giacco, A Mathieu, A Pani, SB Montgomery, G Rosati, J Hillert, S Sawcer, S D'Alfonso, JA Todd, J Novembre, GR Abecasis, MB Whalen, MG Marrosu, A Meloni, S Sanna, M Gorospe, D Schlessinger, E Fiorillo, M Zoledziewska, F Cucca
Jun 27, 2017
Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels.
Michael D Morgan, Etienne Patin, Bernd Jagla, Milena Hasan, Lluís Quintana-Murci, John C Marioni
Mar 12, 2020
GC content shapes mRNA storage and decay in human cells.
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal Cruchez, Zhou Yi, Marianne Bénard, Marie-Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult-Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, Hugues Roest Crollius, Nancy Standart, Dominique Weil
Jan 27, 2020
mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of...
DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids.
Sebastian Canovas, Elena Ivanova, Raquel Romar, Soledad García-Martínez, Cristina Soriano-Úbeda, Francisco A García-Vázquez, Heba Saadeh, Simon Andrews, Gavin Kelsey, Pilar Coy
Jun 24, 2019
The number of children born since the origin of Assisted Reproductive Technologies (ART) exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been reported among ART-conceived infants, suggesting...
Cell cycle regulators control mesoderm specification in human pluripotent stem cells.
Loukia Yiangou, Rodrigo A Grandy, Anna Osnato, Daniel Ortmann, Sanjay Sinha, Ludovic Vallier
Sep 25, 2019
RB transcriptional corepressor 1 (RB1) Cell Cycle cyclin-dependent kinase (CDK) DIFFERENTIATION embryo development Gene Expression Mesoderm Pluripotency signaling Stem Cells tissue regeneration Cell Cycle Cell Differentiation Cell Lineage Cyclin-Dependent Kinases Human Embryonic Stem Cells Humans MAP Kinase Signaling System Mesoderm Protein Kinase Inhibitors Retinoblastoma Binding Proteins Ubiquitin-Protein Ligases
Structural optimality and neurogenetic expression mediate functional dynamics in the human brain.
The human brain exhibits a rich functional repertoire in terms of complex functional connectivity patterns during rest and tasks. However, how this is developed upon a fixed structural anatomy remains poorly understood. Here we...
The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion.
Ting Deng, Przemyslaw Stempor, Alex Appert, Michael Daube, Julie Ahringer, Alex Hajnal, Evelyn Lattmann
May 15, 2020
Cell invasion allows cells to migrate across compartment boundaries formed by basement membranes. Aberrant cell invasion is a first step during the formation of metastases by malignant cancer cells. Anchor cell (AC) invasion in...
Animals Basement Membrane Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Checkpoints Cell Differentiation Cell Proliferation G1 Phase Cell Cycle Checkpoints Gene Expression MDS1 and EVI1 Complex Locus Protein Proto-Oncogene Mas Proto-Oncogene Proteins c-fos Proto-Oncogenes Receptors Notch Signal Transduction Transcription Factors
Data analysis issues for allele-specific expression using Illumina's GoldenGate assay.
Matthew E Ritchie, Matthew S Forrest, Antigone S Dimas, Caroline Daelemans, Emmanouil T Dermitzakis, Panagiotis Deloukas, Simon Tavaré
Jun 14, 2011
Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal.
Yataro Daigo, Ichiro Takayama, Bruce AJ Ponder, Carlos Caldas, Sean M Ward, Kenton M Sanders, Masayuki A Fujino
Jun 16, 2011
Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells.
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