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Metabolic synthetic lethality in cancer therapy
Antimetabolites Antineoplastic Computer Simulation Energy Metabolism Forecasting Gene Dosage Gene Silencing Genes Neoplasm Humans Metabolome Mitochondria Mitochondrial Proteins Models Biological Molecular Targeted Therapy Neoplasm Proteins Neoplasms Oncogenes Oxidative Phosphorylation RNA Interference Synthetic Lethal Mutations
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
Kin Man Suen, Fabian Braukmann, Richard Butler, Dalila Bensaddek, Alper Akay, Chi-Chuan Lin, Dovilė Milonaitytė, Neel Doshi, Alexandra Sapetschnig, Angus Lamond, John Edward Ladbury, Eric Alexander Miska
Jul 30, 2020
Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing. How small ncRNAs utilise phase separated environments for their function is unclear. We investigated how the...
Silencing of StRIK in potato suggests a role in periderm related to RNA processing and stress.
Pau Boher, Marçal Soler, Sandra Fernández-Piñán, Xènia Torrent, Sebastian Y Müller, Krystyna A Kelly, Olga Serra, Mercè Figueras
Dec 24, 2022
BACKGROUND: The periderm is a protective barrier crucial for land plant survival, but little is known about genetic factors involved in its development and regulation. Using a transcriptomic approach in the cork oak (Q. suber)...
flowering Kh-domain Rna-binding Protein Potato Tuber Periderm Rna Regulation Rs2-interacting Kh Protein Arabidopsis Cell Nucleus DNA Transposable Elements Flowers Gene Expression Regulation Plant Gene Regulatory Networks Gene Silencing Plant Proteins Plant Tubers Plants Genetically Modified RNA Plant Solanum tuberosum Stress Physiological
Role and expression of FRS2 and FRS3 in prostate cancer.
Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin, Vincent J Gnanapragasam
Dec 06, 2011
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
Gouji Toyokawa, Ken Masuda, Yataro Daigo, Hyun-Soo Cho, Masanori Yoshimatsu, Masashi Takawa, Shinya Hayami, Kazuhiro Maejima, Makoto Chino, Helen I Field, David E Neal, Eiju Tsuchiya, Bruce AJ Ponder, Yoshihiko Maehara, Yusuke Nakamura, Ryuji Hamamoto
Jun 28, 2011
Biomarkers Tumor Carcinoma Non-Small-Cell Lung Cell Cycle Proteins Cell Line Tumor Cell Proliferation DNA-Binding Proteins Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing HCT116 Cells HEK293 Cells HeLa Cells Hep G2 Cells Humans Lung Neoplasms Minichromosome Maintenance Complex Component 7 Neoplasms Nuclear Proteins Prognosis Protein Binding Protein-Arginine N-Methyltransferases RNA Small Interfering
piRNA-guided co-transcriptional silencing coopts nuclear export factors.
Martin H Fabry, Filippo Ciabrelli, Marzia Munafò, Evelyn L Eastwood, Emma Kneuss, Ilaria Falciatori, Federica A Falconio, Gregory J Hannon, Benjamin Czech
Jun 21, 2019
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In Drosophila, piRNA-guided silencing is achieved, in part...
D. melanogaster PIWI proteins Chromosomes Gene Expression nuclear export factor piRNA pathway transcriptional gene silencing transposon control Active Transport Cell Nucleus Animals Chromatin Drosophila melanogaster Gene Silencing Nuclear Proteins Protein Binding Protein Stability RNA Small Interfering Transcription Genetic
CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines.
Gwladys Zabouo, Anne-Marie Imbert, Jocelyne Jacquemier, Pascal Finetti, Thomas Moreau, Benjamin Esterni, Daniel Birnbaum, François Bertucci, Christian Chabannon
Jun 13, 2011
Adult Aged Aged 80 and over Breast Neoplasms CD146 Antigen Cell Movement Female Flow Cytometry Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing Humans Immunoenzyme Techniques Mesoderm Middle Aged Oligonucleotide Array Sequence Analysis Prognosis RNA Messenger RNA Small Interfering Reverse Transcriptase Polymerase Chain Reaction Tissue Array Analysis Tumor Cells Cultured Young Adult
Left-right dissociation of hippocampal memory processes in mice.
Olivia A Shipton, Mohamady El-Gaby, John Apergis-Schoute, Karl Deisseroth, David M Bannerman, Ole Paulsen, Michael M Kohl
Sep 01, 2014
Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in Trypanosoma brucei.
Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders.
I Conejos-Sánchez, E Gallon, A Niño-Pariente, JA Smith, AG De la Fuente, L Di Canio, S Pluchino, RJM Franklin, MJ Vicent
Jan 24, 2020
Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on...
MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene.
Yu Wei Phua, Akira Nguyen, Daniel L Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea McFarland, Roslin Russell, Warren Kaplan, Mark J Cowley, Radhika Nair, Elena Zotenko, Sandra O'Toole, Shi-Xiong Tan, David E James, Susan J Clark, Hosein Kouros-Mehr, Alexander Swarbrick
May 07, 2019
INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary...
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Cell Transformation Neoplastic Cluster Analysis Epigenesis Genetic Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing Genes Tumor Suppressor Humans Mammary Glands Animal Mice MicroRNAs Neoplasm Metastasis Prognosis Proto-Oncogene Proteins c-akt RNA Interference Sexual Maturation TOR Serine-Threonine Kinases
Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma.
Sarah Moody, Leire Escudero-Ibarz, Ming Wang, Alexandra Clipson, Eguzkine Ochoa Ruiz, Deborah Dunn-Walters, Xuemin Xue, Naiyan Zeng, Alistair Robson, Shih-Sung Chuang, Sergio Cogliatti, Hongxiang Liu, John Goodlad, Margaret Ashton-Key, Markus Raderer, Yingwen Bi, Ming-Qing Du
Dec 04, 2017
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development...
IGHV usage MALT lymphoma NF-κB TNFAIP3 mutation Biomarkers Tumor DNA Mutational Analysis Eye Neoplasms Gene Rearrangement Gene Silencing Genes Immunoglobulin Heavy Chain Genetic Predisposition to Disease Humans Immunoglobulin Variable Region Lymphoma B-Cell Marginal Zone Mutation Neoplasms Adnexal and Skin Appendage Phenotype Tumor Necrosis Factor alpha-Induced Protein 3
Meiotic crossover reduction by virus-induced gene silencing enables the efficient generation of chromosome substitution lines and reverse breeding in Arabidopsis thaliana.
Vanesa Calvo-Baltanás, Cris L Wijnen, Chao Yang, Nina Lukhovitskaya, C Bastiaan de Snoo, Linus Hohenwarter, Joost JB Keurentjes, Hans de Jong, Arp Schnittger, Erik Wijnker
Oct 26, 2020
Plant breeding applications exploiting meiotic mutant phenotypes (like the increase or decrease of crossover (CO) recombination) have been proposed over the last years. As recessive meiotic mutations in breeding lines may affect...
Arabidopsis thaliana MSH5 chromosome substitution lines Meiosis reverse breeding technical advance virus-induced gene silencing Arabidopsis Arabidopsis Proteins Chimera Chromosome Segregation Chromosomes Plant Crossing Over Genetic DNA-Binding Proteins Fertility Gene Expression Regulation Plant Gene Silencing Meiosis Mutation Phenotype plant breeding Transgenes
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation.
Daniel Gebert, Lena K Neubert, Catrin Lloyd, Jinghua Gui, Ruth Lehmann, Felipe Karam Teixeira
Jul 13, 2021
chromosome inversions flamenco Fruit fly Gene Silencing Germ Cells gypsy12 Heterochromatin POSITION-EFFECT VARIEGATION sterility transposable elements Animals Animals Genetically Modified Argonaute Proteins Chromosome Deletion Chromosomes Insect DNA Transposable Elements Drosophila Proteins Drosophila melanogaster evolution Molecular Female Fertility Gene Expression Regulation Developmental Multigene Family Ovary RNA Stability RNA Small Interfering
O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli.
Connor Sharp, Christine Boinett, Amy Cain, Nicholas G Housden, Sandip Kumar, Keith Turner, Julian Parkhill, Colin Kleanthous
Aug 20, 2019
The outer membrane of Gram-negative bacteria presents a significant barrier for molecules entering the cell. Nevertheless, colicins, which are antimicrobial proteins secreted by Escherichia coli, can target other E. coli cells...
bacteriocins cell envelope enteric bacteria outer membrane Anti-Bacterial Agents Colicins DNA Transposable Elements Drug Resistance Bacterial Gene Silencing metabolism Microarray Analysis Microbial Sensitivity Tests Mutagenesis Insertional O Antigens Phenotype Sequence Analysis DNA Uropathogenic Escherichia coli
Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.
Ruth E Schietke, Thomas Hackenbeck, Maxine Tran, Regina Günther, Bernd Klanke, Christina L Warnecke, Karl X Knaup, Deepa Shukla, Christian Rosenberger, Robert Koesters, Sebastian Bachmann, Peter Betz, Gunnar Schley, Johannes Schödel, Carsten Willam, Thomas Winkler, Kerstin Amann, Kai-Uwe Eckardt, Patrick Maxwell, Michael S Wiesener
Mar 19, 2019
The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have deleterious effects. HIF activity is determined by the oxygen regulated...
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.
Sophia von Stockum, Alvaro Sanchez-Martinez, Samantha Corrà, Joy Chakraborty, Elena Marchesan, Lisa Locatello, Caterina Da Rè, Paola Cusumano, Federico Caicci, Vanni Ferrari, Rodolfo Costa, Luigi Bubacco, Maria Berica Rasotto, Ildiko Szabo, Alexander J Whitworth, Luca Scorrano, Elena Ziviani
May 22, 2019
Animals Cell Line Dimethyl Sulfoxide Dopamine Dopaminergic Neurons Down-Regulation Drosophila Drosophila Proteins Drosophila melanogaster Gene Silencing longevity Male Membrane Proteins Mitochondria Parkinson Disease Phenotype Protein Serine-Threonine Kinases Signal Transduction Transfection Ubiquitin-Protein Ligases Ubiquitin-Specific Proteases
Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Guido A Stoll, Shun-Ichiro Oda, Zheng-Shan Chong, Minmin Yu, Stephen H McLaughlin, Yorgo Modis
Jun 19, 2019
Endogenous retrovirus epigenetic silencing transcriptional repressor transposable element ubiquitin E3 ligase Amino Acid Sequence Binding Sites Chromatin Chromatin Assembly and Disassembly Cloning Molecular Crystallography X-Ray Epigenesis Genetic Escherichia coli Gene Expression Gene Silencing Genetic Vectors Humans Models Molecular Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Recombinant Proteins Repressor Proteins Retroelements Sequence Alignment Sequence Homology Amino Acid Transcription Genetic Tripartite Motif-Containing Protein 28
Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
Sara Busacca, Qi Zhang, Annabel Sharkey, Alan G Dawson, David A Moore, David A Waller, Apostolos Nakas, Carolyn Jones, Kelvin Cain, Jin-Li Luo, Adriana Salcedo, Iris Chiara Salaroglio, Chiara Riganti, John Le Quesne, Tom John, Paul C Boutros, Shu-Dong Zhang, Dean A Fennell
Apr 01, 2021
We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase...
Biomarkers Tumor Cell Transformation Neoplastic Gene Deletion Gene Expression Regulation Neoplastic Gene Silencing Humans Kaplan-Meier Estimate Mesothelioma Malignant Prognosis Protein-Arginine N-Methyltransferases Proto-Oncogene Proteins c-jun Purine-Nucleoside Phosphorylase Quinacrine Transcription Genetic
Histone H3 lysine 9 trimethylation is required for suppressing the expression of an embryonically activated retrotransposon in Xenopus laevis.
Sarah Herberg, Angela Simeone, Mami Oikawa, Jerome Jullien, Charles R Bradshaw, Marta Teperek, John Gurdon, Kei Miyamoto
Aug 27, 2015
Guidelines for the functional annotation of microRNAs using the Gene Ontology.
Rachael P Huntley, Dmitry Sitnikov, Marija Orlic-Milacic, Rama Balakrishnan, Peter D'Eustachio, Marc E Gillespie, Doug Howe, Anastasia Z Kalea, Lars Maegdefessel, David Osumi-Sutherland, Victoria Petri, Jennifer R Smith, Kimberly Van Auken, Valerie Wood, Anna Zampetaki, Manuel Mayr, Ruth C Lovering
Jan 22, 2016
The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.
Luke B Hesson, Thomas L Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D Chalmers, Eamonn R Maher, Farida Latif
Jun 13, 2011
Amino Acid Sequence Apoptosis Regulatory Proteins Cell Line Tumor CpG Islands DNA Methylation Gene Expression Regulation Neoplastic Gene Silencing Genes Tumor Suppressor Humans Molecular Sequence Data Monomeric GTP-Binding Proteins Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma Sequence Alignment
Xist-dependent imprinted X inactivation and the early developmental consequences of its failure
M Borensztein, L Syx, K Ancelin, P Diabangouaya, C Picard, T Liu, J-B Liang, I Vassilev, R Galupa, N Servant, E Barillot, A Surani, C-J Chen, E Heard
Mar 13, 2017
Alleles Animals Blastocyst Cell Differentiation dosage compensation Genetic Embryo Implantation Embryo Mammalian Embryonic Development Female Gene Expression Regulation Developmental Gene Knockout Techniques Gene Silencing Genes X-Linked Genomic Imprinting Kinetics Male Mice Inbred C57BL Mutation RNA Long Noncoding Sequence Analysis RNA Single-Cell Analysis Time Factors X Chromosome X Chromosome Inactivation
The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium.
Andrea Frapporti, Caridad Miró Pina, Olivier Arnaiz, Daniel Holoch, Takayuki Kawaguchi, Adeline Humbert, Evangelia Eleftheriou, Bérangère Lombard, Damarys Loew, Linda Sperling, Karine Guitot, Raphaël Margueron, Sandra Duharcourt
Jun 19, 2020
In animals and plants, the H3K9me3 and H3K27me3 chromatin silencing marks are deposited by different protein machineries. H3K9me3 is catalyzed by the SET-domain SU(VAR)3-9 enzymes, while H3K27me3 is catalyzed by the SET-domain...
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