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Distinctive regulatory architectures of germline-active and somatic genes in C. elegans.
Jacques Serizay, Yan Dong, Jürgen Jänes, Michael Chesney, Chiara Cerrato, Julie Ahringer
Jan 18, 2021
RNA profiling has provided increasingly detailed knowledge of gene expression patterns, yet the different regulatory architectures that drive them are not well understood. To address this, we profiled and compared...
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
Kin Man Suen, Fabian Braukmann, Richard Butler, Dalila Bensaddek, Alper Akay, Chi-Chuan Lin, Dovilė Milonaitytė, Neel Doshi, Alexandra Sapetschnig, Angus Lamond, John Edward Ladbury, Eric Alexander Miska
Jul 30, 2020
Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing. How small ncRNAs utilise phase separated environments for their function is unclear. We investigated how the...
The implications of the gender-based prohibitions relating to human germline genome editing in the Human Fertilisation and Embryology Act.
Amarpreet Kaur
Nov 16, 2020
Assisted Reproductive Technologies Gender recognition certificates Germline genome editing Legislation transgender Uterine Transplants Adolescent Adult Aged Aged 80 and over embryology Female Gender Identity Gene Editing Germ Cells Humans Male Middle Aged Surveys and Questionnaires Transgender Persons Young Adult
De-fusing mitochondria defuses the mtDNA time-bomb.
Being uniparentally inherited and with a high mutation rate, mitochondrial DNA (mtDNA) should relentlessly acquire mutations, eventually destroying a species through “mutational meltdown”. Lieber et al. now show that...
Targeted DamID reveals differential binding of mammalian pluripotency factors.
Seth W Cheetham, Wolfram H Gruhn, Jelle van den Ameele, Robert Krautz, Tony D Southall, Toshihiro Kobayashi, M Azim Surani, Andrea H Brand
Oct 03, 2018
The precise control of gene expression by transcription factor networks is crucial to organismal development. The predominant approach for mapping transcription factor-chromatin interactions has been chromatin...
Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment.
Alexandra Bezler, Fabian Braukmann, Sean M West, Arthur Duplan, Raffaella Conconi, Frédéric Schütz, Pierre Gönczy, Fabio Piano, Kristin Gunsalus, Eric A Miska, Laurent Keller
Feb 15, 2019
Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis.
Martin H Fabry, Federica A Falconio, Fadwa Joud, Emily K Lythgoe, Benjamin Czech, Gregory J Hannon
Jul 13, 2021
The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. In Drosophila, piRNAs are intergenerationally inherited through the maternal...
D. melanogaster Drosophila Chromatin Chromosomes developmental biology embryogenesis epigenetics Gene Expression piRNA pathway transposable elements Animals Chromatin DNA Transposable Elements developmental biology Drosophila Drosophila Proteins Drosophila melanogaster Embryonic Development Epigenomics Female Gene Expression Germ Cells Heterochromatin Histones Male Maternal Inheritance RNA Small Interfering
Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis.
Maria Escala-Garcia, Sander Canisius, Renske Keeman, Jonathan Beesley, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Marina Bermisheva, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Federico Canzian, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Fergus J Couch, Kamila Czene, Mary B Daly, Joe Dennis, Peter Devilee, Thilo Dörk, Alison M Dunning, Douglas F Easton, Arif B Ekici, A Heather Eliassen, Peter A Fasching, Henrik Flyger, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Jürgen Geisler, Graham G Giles, Mervi Grip, Melanie Gündert, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Jaana M Hartikainen, Bernadette AM Heemskerk-Gerritsen, Antoinette Hollestelle, Reiner Hoppe, John L Hopper, David J Hunter, William Jacot, Anna Jakubowska, Esther M John, Audrey Y Jung, Rudolf Kaaks, Elza Khusnutdinova, Linetta B Koppert, Peter Kraft, Vessela N Kristensen, Allison W Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Robert N Luben, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Taru A Muranen, Heli Nevanlinna, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Alpa V Patel, Paolo Peterlongo, Paul DP Pharoah, Kevin Punie, Paolo Radice, Gad Rennert, Hedy S Rennert, Atocha Romero, Rebecca Roylance, Thomas Rüdiger, Matthias Ruebner, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Minouk J Schoemaker, Christopher Scott, Melissa C Southey, Harald Surowy, Anthony J Swerdlow, Rulla M Tamimi, Lauren R Teras, Emilie Thomas, Ian Tomlinson, Melissa A Troester, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, kConFab/AOCS Investigators, Kyriaki Michailidou, Georgia Chenevix-Trench, Thomas Bachelot, Marjanka K Schmidt
Nov 25, 2021
Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression...
A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.
Walfred WC Tang, Sabine Dietmann, Naoko Irie, Harry G Leitch, Vasileios I Floros, Charles R Bradshaw, Jamie A Hackett, Patrick F Chinnery, M Azim Surani
Jun 04, 2015
Mechanism and Regulation of P Element Transposition
Drosophila P transposable elements THAP9 hybrid dysgenesis Animals DNA Transposable Elements Drosophila Proteins Drosophila melanogaster Gene Expression Regulation Gene Transfer Horizontal Germ Cells Histones hybridization Genetic Maternal Inheritance Protein Binding Protein Interaction Domains and Motifs Protein Transport RNA Splicing RNA Small Interfering selection Genetic Transposases Vertebrates
Developmental Competence for Primordial Germ Cell Fate.
During mammalian embryonic development, the trophectoderm and primitive endoderm give rise to extraembryonic tissues, while the epiblast differentiates into all somatic lineages and the germline. Remarkably, only a few classes...
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.
Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, YC Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles SH Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
Jan 18, 2021
The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with...
Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro.
Mikael G Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F Chinnery
Apr 01, 2021
Most humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1-2% of molecules, but rapid percentage shifts occur over one generation leading to severe mitochondrial diseases. A decrease in the...
Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans.
Moran Cohen-Berkman, Reut Dudkevich, Shani Ben-Hamo, Alla Fishman, Yehuda Salzberg, Hiba Waldman Ben-Asher, Ayelet T Lamm, Sivan Henis-Korenblit
Apr 06, 2020
How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role...
ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary.
John R Pearson, Federico Zurita, Laura Tomás-Gallardo, Alfonsa Díaz-Torres, María Del Carmen Díaz de la Loza, Kristian Franze, María D Martín-Bermudo, Acaimo González-Reyes
Feb 29, 2016
The specification of imprints in mammals.
At the heart of genomic imprinting in mammals are imprinting control regions (ICRs), which are the discrete genetic elements that confer imprinted monoallelic expression to several genes in imprinted gene clusters. A...
Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate.
Julia Tischler, Wolfram H Gruhn, John Reid, Edward Allgeyer, Florian Buettner, Carsten Marr, Fabian Theis, Ben D Simons, Lorenz Wernisch, M Azim Surani
Nov 16, 2018
cell state transitions Germ Cells metabolism pseudotime analysis single‐cell analysis Animals Cell Differentiation Cells Cultured Embryo Mammalian Embryonic Stem Cells Epigenesis Genetic Female Gene Expression Regulation Developmental Germ Cells Ketoglutaric Acids Male Metabolic Networks and Pathways Mice Mice Inbred C57BL Mice Transgenic Pluripotent Stem Cells
Common germline polymorphisms associated with breast cancer-specific survival.
Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson, Dieter Lambrechts, Caroline Weltens, Karin Leunen, Chantal Van Ongeval, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru A Muranen, Janet E Olsen, Emily Hallberg, Celine Vachon, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Sten Cornelissen, Christopher A Haiman, Brian E Henderson, Frederick Schumacher, Loic Le Marchand, John L Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C Southey, Simon S Cross, Malcolm Wr Reed, Graham G Giles, Roger L Milne, Catriona Mclean, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Maartje J Hooning, Antoinette Hollestelle, John WM Martens, Ans Mw van den Ouweland, Federick Marme, Andreas Schneeweiss, Rongxi Yang, Barbara Burwinkel, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Hermann Brenner, Katja Butterbach, Bernd Holleczek, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Jingmei Li, Judith S Brand, Keith Humphreys, Peter Devilee, Robert AEM Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Filomena Ficarazzi, Matthias W Beckmann, Alexander Hein, Arif B Ekici, Rosemary Balleine, Kelly-Anne Phillips, kConFab Investigators, Javier Benitez, M Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Anna Jakubowska, Jan Lubinski, Jacek Gronwald, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Rüdiger, Sara Margolin, Vessela Kristensen, Siljie Nord, NBCS Investigators, D Gareth Evans, Jean Abraham, Helena Earl, Christopher J Poole, Louise Hiller, Janet A Dunn, Sarah Bowden, Rose Yang, Daniele Campa, W Ryan Diver, Susan M Gapstur, Mia M Gaudet, Susan Hankinson, Robert N Hoover, Anika Hüsing, Rudolf Kaaks, Mitchell J Machiela, Walter Willett, Myrto Barrdahl, Federico Canzian, Suet-Feung Chin, Carlos Caldas, David J Hunter, Sara Lindstrom, Montserrat Garcia-Closas, Fergus J Couch, Georgia Chenevix-Trench, Arto Mannermaa, Irene L Andrulis, Per Hall, Jenny Chang-Claude, Douglas F Easton, Stig E Bojesen, Angela Cox, Peter A Fasching, Paul DP Pharoah, Marjanka K Schmidt
Jun 11, 2015
The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice.
BACKGROUND: Specification of primordial germ cells in mice depends on instructive signalling events, which act first to confer germ cell competence on epiblast cells, and second, to impose a germ cell fate upon competent...
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.
Lenka Gahurova, Shin-Ichi Tomizawa, Sébastien A Smallwood, Kathleen R Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R Andrews, Taiping Chen, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as...
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation.
Daniel Gebert, Lena K Neubert, Catrin Lloyd, Jinghua Gui, Ruth Lehmann, Felipe Karam Teixeira
Jul 13, 2021
chromosome inversions flamenco Fruit fly Gene Silencing Germ Cells gypsy12 Heterochromatin POSITION-EFFECT VARIEGATION sterility transposable elements Animals Animals Genetically Modified Argonaute Proteins Chromosome Deletion Chromosomes Insect DNA Transposable Elements Drosophila Proteins Drosophila melanogaster evolution Molecular Female Fertility Gene Expression Regulation Developmental Multigene Family Ovary RNA Stability RNA Small Interfering
DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes.
Elena Ivanova, Sebastian Canovas, Soledad Garcia-Martínez, Raquel Romar, Jordana S Lopes, Dimitrios Rizos, Maria J Sanchez-Calabuig, Felix Krueger, Simon Andrews, Fernando Perez-Sanz, Gavin Kelsey, Pilar Coy
Jul 14, 2020
Preimplantation embryos experience profound resetting of epigenetic information inherited from the gametes. Genome-wide analysis at single-base resolution has shown similarities but also species differences between human and...
Mitochondrial DNA Heteroplasmy and Purifying Selection in the Mammalian Female Germ Line.
Inherited mutations in the mitochondrial (mt)DNA are a major cause of human disease, with approximately 1 in 5000 people affected by one of the hundreds of identified pathogenic mtDNA point mutations or deletions. Due to the...
On the origin of the human germline.
In mice, primordial germ cells (PGCs), the precursors of eggs and sperm, originate from pregastrulation postimplantation embryos. By contrast, the origin of human PGCs (hPGCs) has been less clear and has been difficult to study...
Amnion Epiblast Epigenetic resetting Gastrulation human development primordial germ cells Signalling Transcription Factors Animals Cell Differentiation Embryo Mammalian Embryonic Development Embryonic Stem Cells Epigenesis Genetic Gene Regulatory Networks Germ Cells Germ Layers Human Embryonic Stem Cells Humans Mice Pluripotent Stem Cells
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