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Results: 28
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Amit Sud, Hauke Thomsen, Giulia Orlando, Asta Försti, Philip J Law, Peter Broderick, Rosie Cooke, Fadi Hariri, Tomi Pastinen, Douglas F Easton, Paul DP Pharoah, Alison M Dunning, Julian Peto, Federico Canzian, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Daniele Campa, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Elke Pogge von Strandmann, Anthony J Swerdlow, Andreas Engert, Nick Orr, Kari Hemminki, Richard S Houlston
Nov 21, 2018
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, GA Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson
Jul 30, 2021
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here, we show that loss-of-function...
Burkitt lymphoma DDX3X Myc RNA helicase Germinal Center proteotoxic stress Translation Adolescent Adult Aged Aged 80 and over Animals B-Lymphocytes Cell Line Tumor Child Child Preschool DEAD-box RNA Helicases Endoplasmic reticulum stress Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Humans Loss of Function Mutation Lymphoma B-Cell Male Mice Transgenic Middle Aged Minor Histocompatibility Antigens Neoplasm Proteins Protein Biosynthesis Proteome Proteostasis Proto-Oncogene Proteins c-myc Young Adult
Type I interferon induces CXCL13 to support ectopic germinal center formation.
Alice E Denton, Silvia Innocentin, Edward J Carr, Barry M Bradford, Fanny Lafouresse, Neil A Mabbott, Urs Mörbe, Burkhard Ludewig, Joanna R Groom, Kim L Good-Jacobson, Michelle A Linterman
Sep 18, 2019
Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection, this response can be beneficial for the host: influenza A virus...
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, María T Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
May 02, 2022
Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy.
M Saeed Qureshi, Jawaher Alsughayyir, Manu Chhabra, Jason M Ali, Martin J Goddard, Christopher A Devine, Thomas M Conlon, Michelle A Linterman, Reza Motallebzadeh, Gavin J Pettigrew
Aug 07, 2019
Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers.
Elizabeth F Wallin, Elaine C Jolly, Ondřej Suchánek, J Andrew Bradley, Marion Espéli, David RW Jayne, Michelle A Linterman, Kenneth GC Smith
Oct 07, 2014
Adolescent Adult Aged Antibodies Monoclonal Murine-Derived Antibody Formation Antigens CD19 B-Lymphocytes CD57 Antigens Cell Differentiation Cells Cultured Coculture Techniques Female Flow Cytometry Germinal Center Humans Immunologic Factors Lymph Nodes Lymphocyte Count Male Middle Aged Receptors CXCR5 Rituximab T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Tumor Necrosis Factor Receptor Superfamily Member 7 Young Adult
Regulation of the Germinal Center Response.
Marisa Stebegg, Saumya D Kumar, Alyssa Silva-Cayetano, Valter R Fonseca, Michelle A Linterman, Luis Graca
Jun 24, 2019
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection. Within...
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.
Alyssa Silva-Cayetano, William S Foster, Silvia Innocentin, Sandra Belij-Rammerstorfer, Alexandra J Spencer, Oliver T Burton, Sigrid Fra-Bidó, Jia Le Lee, Nazia Thakur, Carina Conceicao, Daniel Wright, Jordan Barrett, Nicola Evans-Bailey, Carly Noble, Dalan Bailey, Adrian Liston, Sarah C Gilbert, Teresa Lambe, Michelle A Linterman
Feb 19, 2021
BACKGROUND: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by...
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift.
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence SC Lok, Jeremy A Pike, Jennifer Mueller-Winkler, Thomas W Dennison, John R Ferdinand, Cameron JM Burnett, Juan C Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor LJ Tybulewicz, Antal Rot, Anja E Hauser, Menna R Clatworthy, Kai-Michael Toellner
Jun 07, 2022
Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. Here we follow the migratory...
Leupaxin Expression Is Dispensable for B Cell Immune Responses.
Amélie Bonaud, Simon Clare, Valeria Bisio, John M Sowerby, Shugang Yao, Hanne Ostergaard, Karl Balabanian, Kenneth GC Smith, Marion Espéli
Mar 03, 2020
B cells cell activation humoral immune response leupaxin Plasma Cells Animals Antibody Formation B-Lymphocytes Cell Adhesion Molecules Cell Differentiation Cells Cultured Germinal Center Immunity Humoral Lymphocyte Activation Mice Mice Knockout Plasma Cells Receptors Antigen B-Cell Signal Transduction Transcription Factors
Distribution of horseradish peroxidase (HRP)- anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells
The distribution of immune complexes has been studied in mouse spleen stimulated to contain many germinal centers (GC?s). Horseradish peroxidase (HRP)-anti-HRP complexes were used as an appropriately precise and sensitive model....
Published by: Rockefeller University
T cell Allorecognition Pathways in Solid Organ Transplantation.
Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; and as self-restricted processed alloantigen...
T cell allorecognition T follicular helper cell chronic allograft vasculopathy cytotoxic CD8 T cells exhaustion Germinal Center indirect presentation Transplantation Dendritic Cells Graft Rejection Histocompatibility Antigens Class II Humans Isoantibodies Isoantigens Organ Transplantation T-Lymphocytes Cytotoxic T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Transplantation Homologous
Diverse mutational landscapes in human lymphocytes.
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A Sanders, Alex TJ Cagan, Craig McDonald, Miriam Belmonte, Mairi S Shepherd, Felipe A Vieira Braga, Robert J Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David G Kent, Peter J Campbell
Sep 10, 2022
Spoiling for a Fight
Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from canonical secondary lymphoid organs (SLOs), in...
The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.
Elisa Monzón-Casanova, Michael Screen, Manuel D Díaz-Muñoz, Richard Mr Coulson, Sarah E Bell, Greta Lamers, Michele Solimena, Christopher WJ Smith, Martin Turner
Aug 30, 2018
Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive...
MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.
Rinako Nakagawa, Rebecca Leyland, Michael Meyer-Hermann, Dong Lu, Martin Turner, Giuseppina Arbore, Tri Giang Phan, Robert Brink, Elena Vigorito
May 24, 2019
Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.
Daniel J Hodson, Arthur L Shaffer, Wenming Xiao, George W Wright, Roland Schmitz, James D Phelan, Yandan Yang, Daniel E Webster, Lixin Rui, Holger Kohlhammer, Masao Nakagawa, Thomas A Waldmann, Louis M Staudt
Mar 01, 2016
Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.
Marion Espéli, Menna R Clatworthy, Susanne Bökers, Kate E Lawlor, Antony J Cutler, Frank Köntgen, Paul A Lyons, Kenneth GC Smith
Nov 29, 2018
Genetic variants of the inhibitory Fc receptor FcγRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown...
Animals Autoantibodies Autoimmunity B-Lymphocytes Chromatin Immunoprecipitation DNA Primers Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunospot Assay Flow Cytometry Gene Expression Regulation Gene Knock-In Techniques genetic variation Germinal Center Luciferases Mice Mice Inbred C57BL Mutagenesis Site-Directed Promoter Regions Genetic Receptors IgG Sequence Analysis DNA statistics Nonparametric Transcription Factor AP-1
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination.
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman
Jun 05, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent...
Ageing Dendritic Cells germinal centre response human immunology Inflammation MOUSE T follicular helper cells Adolescent Adoptive Transfer Adult Aged aging Animals B-Lymphocytes Bone Marrow Cells CD11 Antigens Chimera Female Germinal Center Humans Immunity Humoral Immunologic Memory Influenza Vaccines Influenza Human Male Mice Mice Knockout Middle Aged Orthomyxoviridae Infections Receptor Interferon alpha-beta T follicular helper cells T-Lymphocytes Helper-Inducer Vaccination Young Adult
Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.
Cell migration relies on coordinated activity of chemotactic and guidance receptors. Here, we report a specific role for the RNA-binding protein ZFP36L1 in limiting the abundance of molecules involved in the homing of...
Animals Antibody-Producing Cells Antigens B-Lymphocytes Base Sequence Bone Marrow Butyrate Response Factor 1 Cell Count Cell Death Cell Membrane Cell Movement G-Protein-Coupled Receptor Kinase 2 Gene Expression Regulation Germinal Center Immunization Integrins Lysophospholipids Mice Inbred C57BL Receptors CXCR4 Receptors G-Protein-Coupled Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen
The RNA-binding protein HuR is essential for the B cell antibody response.
Manuel D Diaz-Muñoz, Sarah E Bell, Kirsten Fairfax, Elisa Monzon-Casanova, Adam F Cunningham, Mar Gonzalez-Porta, Simon R Andrews, Victoria I Bunik, Kathi Zarnack, Tomaž Curk, Ward A Heggermont, Stephane Heymans, Gary E Gibson, Dimitris L Kontoyiannis, Jernej Ule, Martin Turner
Jun 24, 2019
Post-transcriptional regulation of mRNA by the RNA-binding protein HuR (encoded by Elavl1) is required in B cells for the germinal center reaction and for the production of class-switched antibodies in response to...
Acyltransferases Alternative Splicing Animals Antigens B-Lymphocytes Cell Death Cell Differentiation Cell Proliferation ELAV Proteins Erythrocytes Germinal Center Immunity Humoral Immunization Immunoglobulin Class Switching Immunoglobulins Lipopolysaccharides Mice Mice Inbred C57BL Mice Knockout Mitochondria RNA Messenger Reactive Oxygen Species Sheep
Genetic modification of primary human B cells to model high-grade lymphoma.
Rebecca Caeser, Miriam Di Re, Joanna A Krupka, Jie Gao, Maribel Lara-Chica, João ML Dias, Susanna L Cooke, Rachel Fenner, Zelvera Usheva, Hendrik FP Runge, Philip A Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S Vassiliou, Brian JP Huntly, Annalisa Mupo, Rachael JM Bashford-Rogers, Daniel J Hodson
Sep 13, 2019
Animals B-Lymphocytes CRISPR-Cas Systems Cell Line Tumor Cell Proliferation Coculture Techniques Genetic Vectors Germinal Center High-Throughput Screening Assays Humans Lymphoma Large B-Cell Diffuse Mice Neoplasm Grading Primary Cell Culture Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-bcl-6 Proto-Oncogene Proteins c-myc Retroviridae Transduction Genetic Xenograft Model Antitumor Assays
Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury.
Manu Chhabra, Jawaher Alsughayyir, M Saeed Qureshi, Mekhola Mallik, Jason M Ali, Ivonne Gamper, Ellen L Moseley, Sarah Peacock, Vasilis Kosmoliaptsis, Martin J Goddard, Michelle A Linterman, Reza Motallebzadeh, Gavin J Pettigrew
Feb 19, 2019
Different profiles of alloantibody responses are observed in the clinic, with those that persist, often despite targeted treatment, associated with poorer long-term transplant outcomes. Although such responses would suggest an...
allograft extrafollicular B cell response germinal center (GC) humoral allograft rejection Transplantation Allografts Animals Chronic Disease Disease Models Animal Disease Progression Germinal Center Graft Rejection Heart Transplantation Humans Immunity Humoral Isoantibodies Isoantigens Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Myocardium Receptors Antigen T-Cell alpha-beta Signaling Lymphocytic Activation Molecule Associated Protein Transplantation Homologous
FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
PJ Brown, KK Wong, SL Felce, L Lyne, H Spearman, EJ Soilleux, LM Pedersen, MB Møller, TM Green, DM Gascoyne, AH Banham
Dec 17, 2018
The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL). Here microarray analysis of FOXP1-silenced DLBCL cell lines identified differential regulation of immune...
Adult Aged Aged 80 and over Antibodies Monoclonal Murine-Derived Antigens Differentiation B-Lymphocyte Antineoplastic Combined Chemotherapy Protocols B-Lymphocytes cyclophosphamide Doxorubicin Female Forkhead Transcription Factors Gene Expression Regulation Neoplastic Germinal Center HLA-DR alpha-Chains Histocompatibility Antigens Class II Humans Lymphocyte Activation Lymphoma Large B-Cell Diffuse Male Middle Aged Neoplasm Staging Nuclear Proteins prednisone RNA Small Interfering Repressor Proteins Rituximab Signal Transduction Survival Analysis Trans-Activators Vincristine
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