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Results: 28
The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.
Nicolas Thiebaud, Ida J Llewellyn-Smith, Fiona Gribble, Frank Reimann, Stefan Trapp, Debra Ann Fadool
Mar 01, 2016
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
Alice E Adriaenssens, Emma K Biggs, Tamana Darwish, John Tadross, Tanmay Sukthankar, Milind Girish, Joseph Polex-Wolf, Brain Y Lam, Ilona Zvetkova, Warren Pan, Davide Chiarugi, Giles SH Yeo, Clemence Blouet, Fiona M Gribble, Frank Reimann
Jul 31, 2019
Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and antagonism are effective strategies for inhibiting...
Food intake Glucose-dependent insulinotropic polypeptide Glucose-dependent insulinotropic polypeptide receptor Hypothalamus Aged 80 and over Animals Eating Female Gastric Inhibitory Polypeptide Gene Knock-In Techniques Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Humans Hypothalamus Mice Mice Inbred C57BL Mice Transgenic Neurons obesity Receptors Gastrointestinal Hormone
Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N Christie, Shefeeq M Theparambil, Sean M Davidson, Frank Reimann, Stefan Trapp, Derek M Yellon, Alexander V Gourine
Jan 28, 2022
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments...
Brain capillaries Brain arterioles cerebral blood flow Glucagon-like peptide-1 Ischaemic stroke Middle cerebral artery occlusion Neuroprotection Remote ischaemic preconditioning Animals Arterioles Cerebrovascular Circulation Disease Models Animal Glucagon-Like Peptide-1 Receptor Hindlimb Incretins Infarction Middle Cerebral artery Ischemic preconditioning ischemic stroke Male Neuroprotective Agents Peptide Fragments Rats Sprague-Dawley Regional Blood Flow Vasodilation Vasodilator Agents
Hierarchical neural architecture underlying thirst regulation.
Vineet Augustine, Sertan Kutal Gokce, Sangjun Lee, Bo Wang, Thomas J Davidson, Frank Reimann, Fiona Gribble, Karl Deisseroth, Carlos Lois, Yuki Oka
May 25, 2018
Neural circuits for appetites are regulated by both homeostatic perturbations and ingestive behaviour. However, the circuit organization that integrates these internal and external stimuli is unclear. Here we show in mice that...
L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.
Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M Gribble, Daniel J Drucker, Eelco JP de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W Schwartz, Natalia Petersen
Jan 29, 2020
PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice.
Marie K Holt, Daniel R Cook, Daniel I Brierley, James E Richards, Frank Reimann, Alexander V Gourine, Nephtali Marina, Stefan Trapp
Jun 01, 2020
OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used as anti-diabetic drugs and are approved for obesity treatment. However, GLP-1RAs also affect heart rate (HR) and arterial blood pressure (ABP) in rodents...
Biotelemetry cardiovascular function Chemogenetics GLP-1 PPG neurons Sympathetic outflow Animals Disease Models Animal Electrocardiography Exenatide Glucagon-Like Peptide-1 Receptor Heart Rate Mice Mice Transgenic Neurons Proglucagon Solitary Nucleus Spinal Cord sympathetic nervous system Tachycardia
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure.
Iyas Daghlas, Ville Karhunen, Devleena Ray, Verena Zuber, Stephen Burgess, Philip S Tsao, Julie A Lynch, Kyung Min Lee, Benjamin F Voight, Kyong-Mi Chang, Emma H Baker, Scott M Damrauer, Joanna MM Howson, Marijana Vujkovic, Dipender Gill
May 27, 2021
Background This study was designed to investigate the genetic evidence for repurposing of GLP1R (glucagon-like peptide-1 receptor) agonists to prevent heart failure (HF) and whether the potential benefit exceeds the benefit...
GLP1R Mendelian randomization Diabetes mellitus ejection fraction Heart Failure Biomarkers Blood Glucose Diabetes mellitus Type 2 Drug Repositioning genetic variation Genome-Wide Association Study Glucagon-Like Peptide-1 Receptor Glycated Hemoglobin Heart Failure Humans Hypoglycemic Agents Incretins Mendelian Randomization Analysis Risk Assessment Risk Factors Stroke Volume Treatment Outcome Ventricular Function Left
Evidence for Involvement of GIP and GLP-1 Receptors and the Gut-Gonadal Axis in Regulating Female Reproductive Function in Mice.
Dawood Khan, Opeolu O Ojo, Orla RM Woodward, Jo Edward Lewis, Ananyaa Sridhar, Fiona M Gribble, Frank Reimann, Peter R Flatt, R Charlotte Moffett
Jan 24, 2023
Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.
Stefan Wagner, Daniel I Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian YH Lam, Georgina KC Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M Gribble, Pablo B Martinez de Morentin, Giles SH Yeo, Stefan Trapp, Lora K Heisler
Feb 02, 2023
OBJECTIVE: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like...
HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.
Lukas Steuernagel, Brian YH Lam, Paul Klemm, Georgina KC Dowsett, Corinna A Bauder, John A Tadross, Tamara Sotelo Hitschfeld, Almudena Del Rio Martin, Weiyi Chen, Alain J de Solis, Henning Fenselau, Peter Davidsen, Irene Cimino, Sara N Kohnke, Debra Rimmington, Anthony P Coll, Andreas Beyer, Giles SH Yeo, Jens C Brüning
Nov 20, 2022
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).
Cathryn Weston, Jing Lu, Naichang Li, Kerry Barkan, Gareth O Richards, David J Roberts, Timothy M Skerry, David Poyner, Meenakshi Pardamwar, Christopher A Reynolds, Simon J Dowell, Gary B Willars, Graham Ladds
Jul 24, 2015
Development and characterisation of a novel glucagon like peptide-1 receptor antibody.
Emma K Biggs, Lihuan Liang, Jacqueline Naylor, Shimona Madalli, Rachel Collier, Matthew P Coghlan, David J Baker, David C Hornigold, Peter Ravn, Frank Reimann, Fiona M Gribble
May 31, 2018
AIMS/HYPOTHESIS: Glucagon like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion by binding to GLP-1 receptors (GLP1Rs) on pancreatic beta cells. GLP-1 mimetics are used in the clinic for the treatment of type 2...
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Olga Rudenko, Jin Shang, Alexander Munk, Jeppe P Ekberg, Natalia Petersen, Maja S Engelstoft, Kristoffer L Egerod, Siv A Hjorth, Margaret Wu, Yue Feng, Yun-Ping Zhou, Jacek Mokrosinski, Peter Thams, Frank Reimann, Fiona Gribble, Jens F Rehfeld, Jens J Holst, Jonas T Treebak, Andrew D Howard, Thue W Schwartz
Apr 05, 2019
OBJECTIVES: GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear. METHODS AND...
amino acid sensing G-protein-coupled receptor GPR142 Glucose homeostasis Trp Amino Acids Aromatic Animals Blood Glucose Glucagon Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Glucagon-Secreting Cells Glucose Insulin Insulin-Secreting Cells Islets of Langerhans Male Mice Mice Inbred C57BL Mice Knockout Mice Obese Rats Rats Zucker Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone Receptors Glucagon Tryptophan
Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model.
Paul Richards, Helen E Parker, Alice E Adriaenssens, Joshua M Hodgson, Simon C Cork, Stefan Trapp, Fiona M Gribble, Frank Reimann
Jul 09, 2014
A GLP-1
David C Hornigold, Emma Roth, Victor Howard, Sarah Will, Stephanie Oldham, Matthew P Coghlan, Clemence Blouet, James L Trevaskis
Oct 10, 2018
Combination approaches for the treatment of metabolic diseases such as obesity and diabetes are becoming increasingly relevant. Co-administration of a glucagon-like peptide-1 receptor (GLP-1R) agonist with a cholecystokinin...
Glucagon-like peptide 1 (GLP-1).
TD Müller, B Finan, SR Bloom, D D'Alessio, DJ Drucker, PR Flatt, A Fritsche, F Gribble, HJ Grill, JF Habener, JJ Holst, W Langhans, JJ Meier, MA Nauck, D Perez-Tilve, A Pocai, F Reimann, DA Sandoval, TW Schwartz, RJ Seeley, K Stemmer, M Tang-Christensen, SC Woods, RD DiMarchi, MH Tschöp
Jan 23, 2020
BACKGROUND: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease...
Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain.
Simon C Cork, James E Richards, Marie K Holt, Fiona M Gribble, Frank Reimann, Stefan Trapp
Nov 10, 2017
OBJECTIVE: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable. This study...
AP area postrema BNST bed nucleus stria terminalis Channelrhodopsin DMH dorsomedial nucleus of the hypothalamus DMV dorsal motor nucleus of the vagus Electrophysiology Ex-4 Exendin-4 GFAP glial fibrillary acidic protein GFP green fluorescent protein GLP-1 GLP-1 Glucagon-like peptide-1 GLP-1R Glucagon-like peptide-1 receptor Glucagon-Like Peptide-1 Receptor NAc nucleus accumbens NTS nucleus of the solitary tract PARV parvalbumin PPG PPG preproglucagon PVN paraventricular nucleus of the hypothalamus Preproglucagon TH tyrosine hydroxylase VTA ventral tegmental area YFP yellow fluorescent protein
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Jennifer Wessel, Audrey Y Chu, Sara M Willems, Shuai Wang, Hanieh Yaghootkar, Jennifer A Brody, Marco Dauriz, Marie-France Hivert, Sridharan Raghavan, Leonard Lipovich, Bertha Hidalgo, Keolu Fox, Jennifer E Huffman, Ping An, Yingchang Lu, Laura J Rasmussen-Torvik, Niels Grarup, Margaret G Ehm, Li Li, Abigail S Baldridge, Alena Stančáková, Ravinder Abrol, Céline Besse, Anne Boland, Jette Bork-Jensen, Myriam Fornage, Daniel F Freitag, Melissa E Garcia, Xiuqing Guo, Kazuo Hara, Aaron Isaacs, Johanna Jakobsdottir, Leslie A Lange, Jill C Layton, Man Li, Jing Hua Zhao, Karina Meidtner, Alanna C Morrison, Mike A Nalls, Marjolein J Peters, Maria Sabater-Lleal, Claudia Schurmann, Angela Silveira, Albert V Smith, Lorraine Southam, Marcus H Stoiber, Rona J Strawbridge, Kent D Taylor, Tibor V Varga, Kristine H Allin, Najaf Amin, Jennifer L Aponte, Tin Aung, Caterina Barbieri, Nathan A Bihlmeyer, Michael Boehnke, Cristina Bombieri, Donald W Bowden, Sean M Burns, Yuning Chen, Yii-DerI Chen, Ching-Yu Cheng, Adolfo Correa, Jacek Czajkowski, Abbas Dehghan, Georg B Ehret, Gudny Eiriksdottir, Stefan A Escher, Aliki-Eleni Farmaki, Mattias Frånberg, Giovanni Gambaro, Franco Giulianini, William A Goddard, Anuj Goel, Omri Gottesman, Megan L Grove, Stefan Gustafsson, Yang Hai, Göran Hallmans, Jiyoung Heo, Per Hoffmann, Mohammad K Ikram, Richard A Jensen, Marit E Jørgensen, Torben Jørgensen, Maria Karaleftheri, Chiea C Khor, Andrea Kirkpatrick, Aldi T Kraja, Johanna Kuusisto, Ethan M Lange, IT Lee, Wen-Jane Lee, Aaron Leong, Jiemin Liao, Chunyu Liu, Yongmei Liu, Cecilia M Lindgren, Allan Linneberg, Giovanni Malerba, Vasiliki Mamakou, Eirini Marouli, Nisa M Maruthur, Angela Matchan, Roberta McKean-Cowdin, Olga McLeod, Ginger A Metcalf, Karen L Mohlke, Donna M Muzny, Ioanna Ntalla, Nicholette D Palmer, Dorota Pasko, Andreas Peter, Nigel W Rayner, Frida Renström, Ken Rice, Cinzia F Sala, Bengt Sennblad, Ioannis Serafetinidis, Jennifer A Smith, Nicole Soranzo, Elizabeth K Speliotes, Eli A Stahl, Kathleen Stirrups, Nikos Tentolouris, Anastasia Thanopoulou, Mina Torres, Michela Traglia, Emmanouil Tsafantakis, Sundas Javad, Lisa R Yanek, Eleni Zengini, Diane M Becker, Joshua C Bis, James B Brown, L Adrienne Cupples, Torben Hansen, Erik Ingelsson, Andrew J Karter, Carlos Lorenzo, Rasika A Mathias, Jill M Norris, Gina M Peloso, Wayne H-H Sheu, Daniela Toniolo, Dhananjay Vaidya, Rohit Varma, Lynne E Wagenknecht, Heiner Boeing, Erwin P Bottinger, George Dedoussis, Panos Deloukas, Ele Ferrannini, Oscar H Franco, Paul W Franks, Richard A Gibbs, Vilmundur Gudnason, Anders Hamsten, Tamara B Harris, Andrew T Hattersley, Caroline Hayward, Albert Hofman, Jan-Håkan Jansson, Claudia Langenberg, Lenore J Launer, Daniel Levy, Ben A Oostra, Christopher J O'Donnell, Stephen O'Rahilly, Sandosh Padmanabhan, James S Pankow, Ozren Polasek, Michael A Province, Stephen S Rich, Paul M Ridker, Igor Rudan, Matthias B Schulze, Blair H Smith, André G Uitterlinden, Mark Walker, Hugh Watkins, Tien Y Wong, Eleftheria Zeggini, EPIC-InterAct Consortium, Markku Laakso, Ingrid B Borecki, Daniel I Chasman, Oluf Pedersen, Bruce M Psaty, E Shyong Tai, Cornelia M van Duijn, Nicholas J Wareham, Dawn M Waterworth, Eric Boerwinkle, WH Linda Kao, Jose C Florez, Ruth JF Loos, James G Wilson, Timothy M Frayling, David S Siscovick, Josée Dupuis, Jerome I Rotter, James B Meigs, Robert A Scott, Mark O Goodarzi
Mar 24, 2015
Black People Blood Glucose Diabetes mellitus Type 2 Exome Fasting Genetic Association Studies Genetic Loci Genetic Predisposition to Disease genetic variation Glucagon-Like Peptide-1 Receptor Glucose-6-Phosphatase Humans Insulin Mutation Rate Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide White People
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Robert A Scott, Daniel F Freitag, Li Li, Audrey Y Chu, Praveen Surendran, Robin Young, Niels Grarup, Alena Stancáková, Yuning Chen, Tibor V Varga, Hanieh Yaghootkar, Jian'an Luan, Jing Hua Zhao, Sara M Willems, Jennifer Wessel, Shuai Wang, Nisa Maruthur, Kyriaki Michailidou, Ailith Pirie, Sven J van der Lee, Christopher Gillson, Ali Amin Al Olama, Philippe Amouyel, Larraitz Arriola, Dominique Arveiler, Iciar Aviles-Olmos, Beverley Balkau, Aurelio Barricarte, Inês Barroso, Sara Benlloch Garcia, Joshua C Bis, Stefan Blankenberg, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Ingrid B Borecki, Jette Bork-Jensen, Sarah Bowden, Carlos Caldas, Muriel Caslake, CVD50 consortium, L Adrienne Cupples, Carlos Cruchaga, Jacek Czajkowski, Marcel den Hoed, Janet A Dunn, Helena M Earl, Georg B Ehret, Ele Ferrannini, Jean Ferrieres, Thomas Foltynie, Ian Ford, Nita G Forouhi, Francesco Gianfagna, Carlos Gonzalez, Sara Grioni, Louise Hiller, Jan-Håkan Jansson, Marit E Jørgensen, J Wouter Jukema, Rudolf Kaaks, Frank Kee, Nicola D Kerrison, Timothy J Key, Jukka Kontto, Zsofia Kote-Jarai, Aldi T Kraja, Kari Kuulasmaa, Johanna Kuusisto, Allan Linneberg, Chunyu Liu, Gaëlle Marenne, Karen L Mohlke, Andrew P Morris, Kenneth Muir, Martina Müller-Nurasyid, Patricia B Munroe, Carmen Navarro, Sune F Nielsen, Peter M Nilsson, Børge G Nordestgaard, Chris J Packard, Domenico Palli, Salvatore Panico, Gina M Peloso, Markus Perola, Annette Peters, Christopher J Poole, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, Veikko Salomaa, María-José Sánchez, Naveed Sattar, Stephen J Sharp, Rebecca Sims, Nadia Slimani, Jennifer A Smith, Deborah J Thompson, Stella Trompet, Rosario Tumino, Daphne L van der A, Yvonne T van der Schouw, Jarmo Virtamo, Mark Walker, Klaudia Walter, GERAD_EC Consortium, Neurology Working Group of the Cohorts for Heart, Aging Research in Genomic Epidemiology (CHARGE), Alzheimer’s Disease Genetics Consortium, Pancreatic Cancer Cohort Consortium, European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD), EPIC-InterAct, Jean E Abraham, Laufey T Amundadottir, Jennifer L Aponte, Adam S Butterworth, Josée Dupuis, Douglas F Easton, Rosalind A Eeles, Jeanette Erdmann, Paul W Franks, Timothy M Frayling, Torben Hansen, Joanna MM Howson, Torben Jørgensen, Jaspal Kooner, Markku Laakso, Claudia Langenberg, Mark I McCarthy, James S Pankow, Oluf Pedersen, Elio Riboli, Jerome I Rotter, Danish Saleheen, Nilesh J Samani, Heribert Schunkert, Peter Vollenweider, Stephen O'Rahilly, CHARGE consortium, CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, Panos Deloukas, John Danesh, Mark O Goodarzi, Sekar Kathiresan, James B Meigs, Margaret G Ehm, Nicholas J Wareham, Dawn M Waterworth
Jun 10, 2016
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Julia Ast, Anastasia Arvaniti, Nicholas HF Fine, Daniela Nasteska, Fiona B Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J Jones, Maria A Lucey, Shugo Sasaki, Daniel I Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D'Agostino, Frank Reimann, Francis C Lynn, Christopher A Reissaus, Amelia K Linnemann, Elisa D'Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J Hodson
Jan 29, 2020
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the use of probes that...
Amino Acid Sequence Animals Brain Cell Line Fluorescent Dyes Glucagon-Like Peptide-1 Receptor HEK293 Cells Human Embryonic Stem Cells Humans Islets of Langerhans Mice Mice Knockout Microscopy Fluorescence Multiphoton Models Molecular Molecular Structure Peptide Fragments Signal Transduction Tissue Distribution
Lixisenatide Reduces Chylomicron Triacylglycerol by Increased Clearance.
Martin B Whyte, Fariba Shojaee-Moradie, Sharaf E Sharaf, Nicola C Jackson, Barbara Fielding, Roman Hovorka, Jeewaka Mendis, David Russell-Jones, A Margot Umpleby
Mar 20, 2019
CONTEXT: Glucagon-like peptide-1 (GLP-1) agonists control postprandial glucose and lipid excursion in type 2 diabetes; however, the mechanisms are unclear. OBJECTIVE: To determine the mechanisms of postprandial lipid and glucose...
Central and peripheral GLP-1 systems independently suppress eating.
Daniel I Brierley, Marie K Holt, Arashdeep Singh, Alan de Araujo, Molly McDougle, Macarena Vergara, Majd H Afaghani, Shin Jae Lee, Karen Scott, Calyn Maske, Wolfgang Langhans, Eric Krause, Annette de Kloet, Fiona M Gribble, Frank Reimann, Linda Rinaman, Guillaume de Lartigue, Stefan Trapp
Jan 15, 2021
The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define the peripheral and central GLP-1 systems. PPG neurons in the...
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex SF Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin NA Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn, T2D-GENES consortium and GoT2D consortium
Sep 09, 2016
Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare...
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells.
Zijian Fang, Shiqian Chen, Yusman Manchanda, Stavroula Bitsi, Philip Pickford, Alessia David, Maria M Shchepinova, Ivan R Corrêa, David J Hodson, Johannes Broichhagen, Edward W Tate, Frank Reimann, Victoria Salem, Guy A Rutter, Tricia Tan, Stephen R Bloom, Alejandra Tomas, Ben Jones
Jan 25, 2021
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of the GLP-1R influence its signalling properties and therapeutic...
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