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Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice.
Dipak Sarnobat, R Charlotte Moffett, Victor A Gault, Neil Tanday, Frank Reimann, Fiona M Gribble, Peter R Flatt, Nigel Irwin
Nov 18, 2019
Alpha-cell Glu (CreERT2) ROSA26-eYFP mice Glucose-dependent insulinotropic polypeptide (GIP) Oxytomodulin (Oxm) transdifferentiation Xenin Animals Bacterial Proteins Cell Transdifferentiation Diabetes mellitus Experimental Diabetes mellitus Type 1 Gastric Inhibitory Polypeptide Gastrointestinal Agents Glucagon-Secreting Cells Islets of Langerhans Luminescent Proteins Mice Mice Inbred C57BL Mice Transgenic Neurotensin Oxyntomodulin
Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state
Background: Gastrointestinal hormones regulate intestinal transit, control digestion, influence appetite and promote satiety. Altered production or action of gut hormones, including glucagon-like peptide-1 (GLP-1)...
Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state.
BACKGROUND: Gastrointestinal hormones regulate intestinal transit, control digestion, influence appetite and promote satiety. Altered production or action of gut hormones, including glucagon-like peptide-1 (GLP-1)...
Glucagon-like peptide 1 (GLP-1) analytical chemistry Glucose-dependent insulinotropic polypeptide (GIP) Immunoassay peptide YY (PYY) Adolescent Adult Aged Blood Glucose Fasting Female Gastric Inhibitory Polypeptide Gastrointestinal Hormones Glucagon Glucagon-Like Peptide 1 Glucose Tolerance Test Healthy Volunteers Humans Insulin Male Middle Aged obesity Pancreatic Hormones Peptide YY Postprandial Period Reference Values Young Adult
Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.
Eunyoung Lee, Emily L Miedzybrodzka, Xilin Zhang, Ryo Hatano, Junki Miyamoto, Ikuo Kimura, Kosuke Fujimoto, Satoshi Uematsu, Sergio Rodriguez-Cuenca, Antonio Vidal-Puig, Fiona M Gribble, Frank Reimann, Takashi Miki
Dec 11, 2019
As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However...
Lepob/ob diet-induced obese (DIO) mice Glucose-dependent insulinotropic polypeptide (GIP) High-fat diet interleukin-1 receptor antagonist (IL-1Ra) Leptin Animals Diet High-Fat Gastric Inhibitory Polypeptide Gene Expression Interleukin 1 Receptor Antagonist Protein Leptin Male Mice Inbred C57BL Mice Obese obesity Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone