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Results: 4
Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction.
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Nov 22, 2018
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). Methods: We induced experimental MI in mice by...
The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3.
Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Ingrid den Uijl, Ali Bak Al-Hadithi, Samantha C Salvage, Andrew A Grace, Christopher L-H Huang, Kamalan Jeevaratnam
Sep 29, 2018
Long QT Syndrome 3 (LQTS3) arises from gain-of-function Nav1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent risk for major arrhythmic...
Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy.
Youguo Niu, Andrew D Kane, Ciara M Lusby, Beth J Allison, Yi Yi Chua, Joepe J Kaandorp, Rhiannon Nevin-Dolan, Thomas J Ashmore, Heather L Blackmore, Jan B Derks, Susan E Ozanne, Dino A Giussani
Sep 05, 2018
allopurinol developmental programming Hypoxia Oxidative Stress Pregnancy Rats allopurinol Animals Enzyme Inhibitors Female Heart Failure Heart Function Tests Hypoxia Male Myocardial Contraction Oxidative Stress Pregnancy Pregnancy Complications Rats Receptor Muscarinic M2 Receptors Adrenergic beta Sarcoplasmic Reticulum Calcium-Transporting ATPases sympathetic nervous system xanthine oxidase
Fetal in vivo continuous cardiovascular function during chronic hypoxia.
BJ Allison, KL Brain, Y Niu, AD Kane, EA Herrera, AS Thakor, KJ Botting, CM Cross, N Itani, KL Skeffington, C Beck, DA Giussani
Sep 16, 2015