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BACKGROUND: Donor-specific antibodies of the IgG isotype are measured routinely for diagnostic purposes in renal transplant recipients and are associated with antibody-mediated rejection and long-term graft loss. OBJECTIVE: This...

IgE Transplantation alloreactivity donor-specific antibodies humoral rejection immunology Allografts Animals Female Graft Rejection Heart Transplantation Histocompatibility Antigens Class I Histocompatibility Antigens Class II Humans Immunoglobulin E Immunoglobulin G Kidney Transplantation Male Mice Mice Inbred BALB C Skin Transplantation

Chronic rejection is the major cause of long-term heart allograft failure, characterized by tissue infiltration by recipient T cells with indirect allospecificity. Phosphoinositol-3-kinase p110δ is a key mediator of T cell...

adenine Animals Cells Cultured Chronic Disease Class Ia Phosphatidylinositol 3-Kinase Female Flow Cytometry Graft Rejection H-Y Antigen Heart Transplantation Humans Immune Tolerance Male Mice Mice Inbred C57BL Mice Knockout Microscopy Fluorescence Phosphoinositide-3 Kinase Inhibitors Quinazolines Skin Transplantation T-Lymphocytes Transplantation Homologous

AIMS: Membrane-bound angiotensin-converting enzyme (ACE)2 is the main cellular access point for SARS-CoV-2, but its expression and the effect of ACE inhibition have not been assessed quantitatively in patients with heart...

covid-19 SARS-CoV-2 Heart failure Heart transplantation ACE inhibitor Angiotensin-Converting Enzyme 2 Angiotensin-Converting Enzyme Inhibitors Heart Transplantation Humans

Humoral alloimmunity is now recognized as a major determinant of transplant outcome. MHC glycoprotein is considered a typical T-dependent antigen, but the nature of the T cell alloresponse that underpins alloantibody generation...

allograft extrafollicular B cell response germinal center (GC) humoral alloimmunity Transplantation vasculopathy Adoptive Transfer Allografts Animals B-Lymphocytes DNA-Binding Proteins Disease Models Animal Disease Progression Graft Rejection Heart Transplantation Humans Isoantibodies Isoantigens Lymphocyte Count Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Myocardium Receptors Antigen T-Cell alpha-beta Signaling Lymphocytic Activation Molecule Associated Protein T-Lymphocytes Helper-Inducer Transplantation Homologous

Allografts Animals Autoantigens Autoimmunity blood vessels Disease Models Animal Disease Progression Epitopes T-Lymphocyte Germinal Center Graft Rejection Heart Transplantation Humans Immunity Humoral Mice Mice Inbred BALB C Mice Inbred C57BL Mice Transgenic T-Lymphocytes

Adaptive Immunity Animals Antigen Presentation CD4-Positive T-Lymphocytes Heart Transplantation Histocompatibility Antigens Class I Immunity Innate Isoantigens Lymphocyte Activation Mice Inbred BALB C Mice Inbred C57BL Peptides Transplantation Homologous

CD8 cytotoxicity alloimmunity allorecognition semidirect allorecognition semidirect pathway Allografts Animals CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Dendritic Cells Graft Rejection Heart Transplantation Histocompatibility Antigens Class I Isoantigens Mice Mice Inbred BALB C Mice Knockout

The determination of the sample size required by a crossover trial typically depends on the specification of one or more variance components. Uncertainty about the value of these parameters at the design stage means that there...

blinded crossover trial internal pilot study sample size reestimation Biometry Clinical Trials as Topic Cross-Over Studies Heart Transplantation Humans Kaplan-Meier Estimate Models Statistical Regression Analysis Sample Size statistics Nonparametric

Donor-transmitted cancer (DTC) has major implications for the affected patient as well as other recipients of organs from the same donor. Unlike heterotopic transplant recipients, there may be limited treatment options for...

Cancer Heart Transplantation Liver Transplantation Lung Transplantation Deceased Organ Donors Donor-transmitted Disease Humans Neoplasm Recurrence Local Organ Transplantation Transplants Tissue Donors Transplant Recipients

T cell biology basic (laboratory) research/science cellular biology immune regulation immunobiology lymphocyte biology organ transplantation in general tolerance: experimental tolerance: mechanisms translational research/science Adoptive Transfer Allografts Animals Cell Lineage Graft Rejection Graft Survival Heart Transplantation Humans Immune System Immunity Humoral Isoantibodies Kidney Transplantation Lung Transplantation Mice Organ Preservation Perfusion T-Lymphocytes Regulatory Tissue Donors Transplantation Homologous Treatment Outcome

Different profiles of alloantibody responses are observed in the clinic, with those that persist, often despite targeted treatment, associated with poorer long-term transplant outcomes. Although such responses would suggest an...

allograft extrafollicular B cell response germinal center (GC) humoral allograft rejection Transplantation Allografts Animals Chronic Disease Disease Models Animal Disease Progression Germinal Center Graft Rejection Heart Transplantation Humans Immunity Humoral Isoantibodies Isoantigens Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Myocardium Receptors Antigen T-Cell alpha-beta Signaling Lymphocytic Activation Molecule Associated Protein Transplantation Homologous

Heart-brain integration dynamics are critical for interoception (i.e. the sensing of body signals). In this unprecedented longitudinal study, we assessed neurocognitive markers of interoception in patients who underwent...

Heart Transplantation heartbeat detection heartbeat evoked potential Interoception vagus nerve denervation

England Heart Failure Heart Transplantation Proportional Hazards Models Adult Age Factors Comorbidity England Female Health Status Disparities Healthcare Disparities Heart Failure Heart Transplantation Humans Linear Models Logistic Models Male Middle Aged Multivariate Analysis Poverty Proportional Hazards Models Registries Risk Assessment Risk Factors Sex Factors Time Factors Tissue and Organ Procurement Treatment Outcome