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The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal...

Cell Movement Hedgehog Proteins Signal Transduction Smoothened Receptor Ubiquitin-Protein Ligases

Adult Animals Colitis Ulcerative Hedgehog Proteins Humans Mice Signal Transduction Th17 Cells Virulence

Animals Cell Proliferation Cyclin A Cyclin E Drosophila Drosophila Proteins Eye G1 Phase Gene Expression Regulation Developmental Hedgehog Proteins Immunohistochemistry Microscopy Confocal Transcription Factors

V3 spinal interneurons are a key element of the spinal circuits, which control motor function. However, to date, there are no effective ways of deriving a pure V3 population from human pluripotent stem cells. Here, we report a...

Humans Cell Differentiation Hedgehog Proteins Human Embryonic Stem Cells Interneurons Motor Neurons Spinal Cord Homeobox Protein Nkx-2.2

Hedgehog Hippo competition stem cell Testis Animals Cell Differentiation Cell Proliferation Clone Cells Drosophila Drosophila Proteins Hedgehog Proteins Intracellular Signaling Peptides and Proteins Male Models Theoretical Mutation Phenotype Protein Serine-Threonine Kinases Receptors Cell Surface Signal Transduction Stem Cell Niche Stem Cells Testis

During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here, we combine whole-genome...

Bcl6 FGF signaling notch signaling Shh signaling Wnt signaling brain development Cyclins Neurogenesis stemness Transcription Animals Cell Self Renewal Epigenetic Repression Fibroblast Growth Factors Gene Expression Profiling Hedgehog Proteins Histone Code Histones Mice Neural Stem Cells Neurogenesis Proto-Oncogene Proteins c-bcl-6 RNA-seq Receptors Notch Signal Transduction Sirtuin 1 Wnt Signaling Pathway

Appendage patterning evolution Gill arch Leucoraja erinacea Skate Sonic hedgehog Animals Extremities Gene Expression Gills Hedgehog Proteins Limb Buds Signal Transduction Skates Fish

The cerebellum undergoes rapid growth during the third trimester and is vulnerable to injury and deficient growth in infants born prematurely. Factors associated with preterm cerebellar hypoplasia include chronic lung disease...

brain development cerebral palsy Glucocorticoid HIF signaling Hypoxia Shh signaling Amino Acids Dicarboxylic Animals Animals Newborn Anti-Inflammatory Agents Basic Helix-Loop-Helix Transcription Factors Calcium-Binding Proteins Cell Proliferation Cells Cultured cerebellum Cyclohexylamines Developmental Disabilities Disease Models Animal Gene Expression Regulation Developmental Glucocorticoids Hedgehog Proteins Hypoxia Brain Mice Mice Inbred C57BL Mice Transgenic Microfilament Proteins Nerve Tissue Proteins Nervous System Malformations Neuroprotective Agents Prednisolone Purkinje Cells Thiophenes Von Hippel-Lindau Tumor Suppressor Protein Zinc Finger Protein GLI1

5-hydroxymethylcytosine 5hmC DNA Methylation TET methylcytosine oxidases cholesterol biosynthesis 5-Methylcytosine Animals Biomarkers Blastocyst Blastomeres Cell Lineage Cholesterol DNA DNA-Binding Proteins Dioxygenases Down-Regulation Embryo Loss Embryo Mammalian Embryonic Development Gene Deletion Gene Expression Regulation Developmental Genomic Imprinting Hedgehog Proteins Mice Inbred C57BL Mice Knockout Proto-Oncogene Proteins Repetitive Sequences Nucleic Acid Sequence Analysis RNA Signal Transduction Transcriptome

and neonatal diseases and abnormalities Cerebellar Diseases Congenital Genetics hereditary Mutation Animals Hedgehog Proteins Holoprosencephaly Humans Mammals Mutation Phenotype Type C Phospholipases

Cholesterol can regulate the Hedgehog signalling pathway by directly binding to a receptor on the cell surface.

G-protein coupled receptor hedgehog signaling Biochemistry Cholesterol developmental biology human MOUSE Stem Cells Carrier Proteins Cell Membrane Hedgehog Proteins Humans Lipids Receptors Cell Surface Receptors G-Protein-Coupled Signal Transduction

Animals Apoptosis Carcinoma Basal Cell Cell Self Renewal Cell Survival Clone Cells Disease Progression epidermis Female Hedgehog Proteins Homeostasis Male Mice Mutation Neoplastic Stem Cells Oncogenes Signal Transduction Skin Neoplasms Tail Tumor Suppressor Protein p53

The Hedgehog (Hh) pathway is essential for embryonic development and tissue homeostasis. Aberrant Hh signaling may occur in a wide range of human cancers, such as medulloblastoma, the most common brain malignancy in childhood....

Aminopeptidases Animals Carcinogenesis Hedgehog Proteins Mice Minor Histocompatibility Antigens NIH 3T3 Cells Protein Stability Proteolysis Signal Transduction Ubiquitin-Specific Proteases beta-Transducin Repeat-Containing Proteins

The Hedgehog (Hh) signalling pathway plays important roles during embryonic development and in adult tissue homeostasis, for example cartilage, where its deregulation can lead to osteoarthritis (OA). microRNAs (miRNAs) are...

Cartilage Glypicans Hedgehog signalling Osteoarthritis Osteogenesis SILAC microRNA 3' Untranslated Regions Adult Animals Cartilage Cell Line Disease Models Animal Gene Expression Regulation Genes Reporter Glypicans Hedgehog Proteins Humans Luciferases Mesenchymal Stem Cells Mice MicroRNAs Osteoarthritis RNA Small Interfering Signal Transduction Smoothened Receptor Species Specificity Zinc Finger Protein GLI1

Cerebellar neural stem cells (NSCs) require Hedgehog-Gli (Hh-Gli) signalling for their maintenance and Nanog expression for their self-renewal. To identify novel molecular features of this regulatory pathway, we used...

Animals Animals Newborn Cell Differentiation Cell Proliferation cerebellum Forkhead Box Protein M1 Gene Expression Regulation Developmental Hedgehog Proteins High-Throughput Nucleotide Sequencing Mice Mice Inbred C57BL MicroRNAs Nanog Homeobox Protein Neural Stem Cells Neurogenesis Primary Cell Culture Signal Transduction Spheroids Cellular Zinc Finger Protein GLI1

The gill skeleton of cartilaginous fishes (sharks, skates, rays, and holocephalans) exhibits a striking anterior-posterior polarity, with a series of fine appendages called branchial rays projecting from the posterior margin of...

SHH Wnt developmental biology evolutionary biology Gill arch pharyngeal arch skate leucoraja erinacea Skeleton Animals Branchial Region Wnt Signaling Pathway Hedgehog Proteins Ectoderm Gills Skates Fish Skeleton