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Results: 129
PAGA
F Alexander Wolf, Fiona K Hamey, Mireya Plass, Jordi Solana, Joakim S Dahlin, Berthold Göttgens, Nikolaus Rajewsky, Lukas Simon, Fabian J Theis
Feb 18, 2019
Clonal approaches to understanding the impact of mutations on hematologic disease development.
Interrogation of hematopoietic tissue at the clonal level has a rich history spanning over 50 years, and has provided critical insights into both normal and malignant hematopoiesis. Characterization of chromosomes identified...
lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation.
M Joaquina Delás, Benjamin T Jackson, Tatjana Kovacevic, Silvia Vangelisti, Ester Munera Maravilla, Sophia A Wild, Eva Maria Stork, Nicolas Erard, Simon RV Knott, Gregory J Hannon
Apr 05, 2019
HSC Hematopoiesis lncRNA Oxidative Phosphorylation Animals Bone Marrow Transplantation Cell Differentiation Cell Line Tumor Cell Lineage Cyclin-Dependent Kinase 6 Female GATA2 Transcription Factor Hematopoiesis Hematopoietic Stem Cells Mice Mice Inbred C57BL Oxidative Phosphorylation Proto-Oncogene Proteins RNA Interference RNA Long Noncoding RNA Small Interfering Regeneration Trans-Activators
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.
Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Feb 04, 2019
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Morgan Oatley, Özge Vargel Bölükbası, Valentine Svensson, Maya Shvartsman, Kerstin Ganter, Katharina Zirngibl, Polina V Pavlovich, Vladislava Milchevskaya, Vladimira Foteva, Kedar N Natarajan, Bianka Baying, Vladimir Benes, Kiran R Patil, Sarah A Teichmann, Christophe Lancrin
Mar 05, 2020
The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). The intermediary steps of this process are unclear, in...
Animals Aorta arteries Biomarkers Cell Cycle Citric Acid Cycle Computational Biology Core Binding Factor Alpha 2 Subunit Down-Regulation Endothelium Glycolysis Gonads Hematopoiesis Hematopoietic Stem Cells Hyaluronan Receptors Hyaluronic Acid Mesonephros Mice Mice Inbred C57BL Mice Knockout Transcriptome Transforming Growth Factor beta
Advancing haematopoietic stem and progenitor cell biology through single-cell profiling.
Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.
Debbie K Goode, Nadine Obier, MS Vijayabaskar, Michael Lie-A-Ling, Andrew J Lilly, Rebecca Hannah, Monika Lichtinger, Kiran Batta, Magdalena Florkowska, Rahima Patel, Mairi Challinor, Kirstie Wallace, Jane Gilmour, Salam A Assi, Pierre Cauchy, Maarten Hoogenkamp, David R Westhead, Georges Lacaud, Valerie Kouskoff, Berthold Göttgens, Constanze Bonifer
Mar 01, 2016
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment.
Fizzah A Choudry, Frederik O Bagger, Iain C Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F Martin, Anthony Mathur, Willem H Ouwehand, Elisa Laurenti, Sarah A Teichmann, Mattia Frontini
Mar 15, 2021
BACKGROUND: Megakaryocytes (MKs) originate from cells immuno-phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release...
EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors.
Aurelie Lenaerts, Iwo Kucinski, Ward Deboutte, Marta Derecka, Pierre Cauchy, Thomas Manke, Berthold Göttgens, Rudolf Grosschedl
Oct 01, 2022
Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection.
Myriam LR Haltalli, Samuel Watcham, Nicola K Wilson, Kira Eilers, Alexander Lipien, Heather Ang, Flora Birch, Sara Gonzalez Anton, Chiara Pirillo, Nicola Ruivo, Maria L Vainieri, Constandina Pospori, Robert E Sinden, Tiago C Luis, Jean Langhorne, Ken R Duffy, Berthold Göttgens, Andrew M Blagborough, Cristina Lo Celso
Aug 13, 2020
Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis.
Fang Dong, Sha Hao, Sen Zhang, Caiying Zhu, Hui Cheng, Zining Yang, Fiona K Hamey, Xiaofang Wang, Ai Gao, Fengjiao Wang, Yun Gao, Ji Dong, Chenchen Wang, Jinyong Wang, Yu Lan, Bing Liu, Hideo Ema, Fuchou Tang, Berthold Göttgens, Ping Zhu, Tao Cheng
Mar 04, 2020
Bone marrow niches in haematological malignancies.
Simón Méndez-Ferrer, Dominique Bonnet, David P Steensma, Robert P Hasserjian, Irene M Ghobrial, John G Gribben, Michael Andreeff, Daniela S Krause
Mar 05, 2020
The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions.
As for many other adult stem cells, the behavior of hematopoietic stem and progenitor cells (HSPCs) is subjected to circadian regulatory patterns. Multiple HSPC functions, such as proliferation, differentiation or trafficking...
adrenergic Autonomic Nervous System cholinergic Circadian hematopoietic (stem) cells Adrenergic Neurons Animals Autonomic Nervous System Bone Marrow Cell Differentiation Cell Proliferation Cholinergic Neurons Circadian Rhythm Gene Expression Regulation Hematopoietic Stem Cells Humans Periodicity Signal Transduction Stem Cell Niche Suprachiasmatic Nucleus Time Factors
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Akihiko Numata, Hui Si Kwok, Qi-Ling Zhou, Jia Li, Roberto Tirado-Magallanes, Vladimir Espinosa Angarica, Rebecca Hannah, Jihye Park, Chelsia Qiuxia Wang, Vaidehi Krishnan, Deepa Rajagopalan, Yanzhou Zhang, Siqin Zhou, Robert S Welner, Motomi Osato, Sudhakar Jha, Stefan K Bohlander, Berthold Göttgens, Henry Yang, Touati Benoukraf, John W Lough, Deepak Bararia, Daniel G Tenen
May 15, 2020
Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics.
Suwei Gao, Qiang Shi, Yifan Zhang, Guixian Liang, Zhixin Kang, Baofeng Huang, Dongyuan Ma, Lu Wang, Jianwei Jiao, Xiangdong Fang, Cheng-Ran Xu, Longqi Liu, Xun Xu, Berthold Göttgens, Cheng Li, Feng Liu
Jul 14, 2021
CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation.
Hannah Lawson, Louie N van de Lagemaat, Melania Barile, Andrea Tavosanis, Jozef Durko, Arnaud Villacreces, Aarushi Bellani, Christopher Mapperley, Elise Georges, Catarina Martins-Costa, Catarina Sepulveda, Lewis Allen, Joana Campos, Kirsteen J Campbell, Dónal O'Carroll, Berthold Göttgens, Suzanne Cory, Neil P Rodrigues, Amelie V Guitart, Kamil R Kranc
Oct 06, 2021
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITED2 is essential for life-long HSC...
CITED2 MCL-1 PTEN Hematopoiesis Hematopoietic stem cell Animals Apoptosis Cell Proliferation Gene Expression Regulation Gene Regulatory Networks Hematopoiesis Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Mice Inbred C57BL Mice Knockout RNA-seq Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Time Factors Trans-Activators
CODEX
Manuel Sánchez-Castillo, David Ruau, Adam C Wilkinson, Felicia SL Ng, Rebecca Hannah, Evangelia Diamanti, Patrick Lombard, Nicola K Wilson, Berthold Gottgens
Sep 29, 2014
Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes.
Andrés García-García, Claudia Korn, María García-Fernández, Olivia Domingues, Javier Villadiego, Daniel Martín-Pérez, Joan Isern, José A Bejarano-García, Jacques Zimmer, José A Pérez-Simón, Juan J Toledo-Aral, Tatiana Michel, Matti S Airaksinen, Simón Méndez-Ferrer
Dec 07, 2018
Hematopoietic stem and progenitor cells (HSPCs) and leukocytes circulate between the bone marrow (BM) and peripheral blood following circadian oscillations. Autonomic sympathetic noradrenergic signals have been shown to regulate...
Animals Bone Marrow Cells Cell Adhesion Cell Movement Cells Cultured Chemotaxis Cholinergic Agents Circadian Rhythm Endothelium Vascular Female Glial Cell Line-Derived Neurotrophic Factor Receptors Hematopoietic Stem Cells Leukocytes Male Mice Mice Inbred C57BL Mice Knockout Parasympathetic Nervous System Receptors Adrenergic beta-2 Receptors Adrenergic beta-3 Receptors G-Protein-Coupled sympathetic nervous system
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Ya-Hsuan Ho, Raquel Del Toro, José Rivera-Torres, Justyna Rak, Claudia Korn, Andrés García-García, David Macías, Cristina González-Gómez, Alberto Del Monte, Monika Wittner, Amie K Waller, Holly R Foster, Carlos López-Otín, Randall S Johnson, Claus Nerlov, Cedric Ghevaert, William Vainchenker, Fawzia Louache, Vicente Andrés, Simón Méndez-Ferrer
Jun 20, 2019
Hutchinson-Gilford progeria aging Hematopoietic stem cell lymphoid microenvironment myeloid niche Adrenergic Agonists aging aging Premature Animals Bone Marrow Cell Differentiation Cell Encapsulation Cell Proliferation Disease Models Animal Hematopoietic Stem Cells Humans Interleukin-6 Megakaryocytes Mice Myeloid Cells Nitric Oxide Synthase Type I progeria Receptors Adrenergic beta-2 Signal Transduction Stem Cell Niche
Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.
Juan Li, Daniel Prins, Hyun Jung Park, Jacob Grinfeld, Carlos Gonzalez-Arias, Stephen Loughran, Oliver M Dovey, Thorsten Klampfl, Cavan Bennett, Tina L Hamilton, Dean C Pask, Rachel Sneade, Matthew Williams, Juliet Aungier, Cedric Ghevaert, George S Vassiliou, David G Kent, Anthony R Green
Mar 07, 2018
Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). Multiple different mutations have...
Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq.
Fabienne Lescroart, Xiaonan Wang, Xionghui Lin, Benjamin Swedlund, Souhir Gargouri, Adriana Sànchez-Dànes, Victoria Moignard, Christine Dubois, Catherine Paulissen, Sarah Kinston, Berthold Göttgens, Cédric Blanpain
Mar 20, 2018
Mouse heart development arises from Mesp1-expressing cardiovascular progenitors (CPs) that are specified during gastrulation. The molecular processes that control early regional and lineage segregation of CPs have been unclear....
Population dynamics of normal human blood inferred from somatic mutations.
Henry Lee-Six, Nina Friesgaard Øbro, Mairi S Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J Osborne, Brian JP Huntly, Inigo Martincorena, Elizabeth Anderson, Laura O'Neill, Michael R Stratton, Elisa Laurenti, Anthony R Green, David G Kent, Peter J Campbell
Sep 21, 2018
Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.
Ximena Ibarra-Soria, Wajid Jawaid, Blanca Pijuan-Sala, Vasileios Ladopoulos, Antonio Scialdone, David J Jörg, Richard CV Tyser, Fernando J Calero-Nieto, Carla Mulas, Jennifer Nichols, Ludovic Vallier, Shankar Srinivas, Benjamin D Simons, Berthold Göttgens, John C Marioni
Feb 02, 2018
During gastrulation, cell types from all three germ layers are specified and the basic body plan is established 1 . However, molecular analysis of this key developmental stage has been hampered by limited cell numbers and a...
Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes.
H Dolatshad, A Pellagatti, FG Liberante, M Llorian, E Repapi, V Steeples, S Roy, L Scifo, RN Armstrong, J Shaw, BH Yip, S Killick, R Kušec, S Taylor, KI Mills, KI Savage, CWJ Smith, J Boultwood
Aug 14, 2017
The splicing factor SF3B1 is the most frequently mutated gene in myelodysplastic syndromes (MDS), and is strongly associated with the presence of ring sideroblasts (RS). We have performed a systematic analysis of cryptic...
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