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Allograft rejection is associated with development of functional IgE specific for donor MHC antigens.
Andreas M Farkas, Ulrike Baranyi, Georg A Böhmig, Lukas Unger, Stefan Hopf, Markus Wahrmann, Heinz Regele, Benedikt Mahr, Christoph Schwarz, Karin Hock, Nina Pilat, Ivan Kristo, Jasmin Mraz, Christian Lupinek, Josef Thalhamer, Gregor Bond, Lorenz Kuessel, Elizabeth Wlodek, Jack Martin, Menna Clatworthy, Gavin Pettigrew, Rudolf Valenta, Thomas Wekerle
Dec 17, 2018
BACKGROUND: Donor-specific antibodies of the IgG isotype are measured routinely for diagnostic purposes in renal transplant recipients and are associated with antibody-mediated rejection and long-term graft loss. OBJECTIVE: This...
IgE Transplantation alloreactivity donor-specific antibodies humoral rejection immunology Allografts Animals Female Graft Rejection Heart Transplantation Histocompatibility Antigens Class I Histocompatibility Antigens Class II Humans Immunoglobulin E Immunoglobulin G Kidney Transplantation Male Mice Mice Inbred BALB C Skin Transplantation
Introduction
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pathogens whilst maintaining tolerance to the host. It encodes molecules that act as sentinels, providing a snapshot of the health...
Deletion of IRF8 (Interferon Regulatory Factor 8)-Dependent Dendritic Cells Abrogates Proatherogenic Adaptive Immunity.
Marc Clément, Yacine Haddad, Juliette Raffort, Fabien Lareyre, Stephen A Newland, Leanne Master, James Harrison, Maria Ozsvar-Kozma, Patrick Bruneval, Christoph J Binder, Soraya Taleb, Ziad Mallat
Jun 20, 2018
RATIONALE: Despite an established role for adaptive immune responses in atherosclerosis, the contribution of dendritic cells (DCs) and their various subsets is still poorly understood. OBJECTIVE: Here, we address the role of...
Influence of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Population and Individual Level.
Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules, by CD4+ T-cells. We capitalised on extensive...
Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter.
Androniki Psifidi, Andreas Kranis, Lisa M Rothwell, Abi Bremner, Kay Russell, Diego Robledo, Stephen J Bush, Mark Fife, Paul M Hocking, Georgios Banos, David A Hume, Jim Kaufman, Richard A Bailey, Santiago Avendano, Kellie A Watson, Pete Kaiser, Mark P Stevens
Jan 12, 2021
A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis.
Raquel López-Mejías, F David Carmona, Santos Castañeda, Fernanda Genre, Sara Remuzgo-Martínez, Belén Sevilla-Perez, Norberto Ortego-Centeno, Javier Llorca, Begoña Ubilla, Verónica Mijares, Trinitario Pina, José A Miranda-Filloy, Antonio Navas Parejo, Diego de Argila, Maximiliano Aragües, Esteban Rubio, Manuel León Luque, Juan María Blanco-Madrigal, Eva Galíndez-Aguirregoikoa, David Jayne, Ricardo Blanco, Javier Martín, Miguel A González-Gay
Feb 24, 2020
The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS)...
Polymorphisms in MHC class I molecules influence their interactions with components of the antigen processing and presentation pathway.
MHC class I (MHC-I) molecules undergo an intricate folding process in order to pick up antigenic peptide to present to the immune system. In recent years, the discovery of a new peptide editor for MHC-I has added an extra level...
The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee, Luca D Bertzbach, Benedikt B Kaufer, Martin C Moncrieffe, Bernd Kaspers, Sonja Härtle, Jim Kaufman
May 06, 2021
Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation.
Jakob Loschko, Heidi A Schreiber, Gereon J Rieke, Daria Esterházy, Matthew M Meredith, Virginia A Pedicord, Kai-Hui Yao, Silvia Caballero, Eric G Pamer, Daniel Mucida, Michel C Nussenzweig
Sep 19, 2019
Conventional dendritic cells (cDCs) play an essential role in host immunity by initiating adaptive T cell responses and by serving as innate immune sensors. Although both innate and adaptive functions of cDCs are well...
An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.
Jin Xiao, Wangzhen Xiang, Yongli Zhang, Weiyu Peng, Min Zhao, Ling Niu, Yan Chai, Jianxun Qi, Fei Wang, Peng Qi, Chungang Pan, Lingxia Han, Ming Wang, Jim Kaufman, George F Gao, William J Liu
Dec 17, 2018
MHC molecules are found in all jawed vertebrates and are known to present peptides to T lymphocytes. In mammals, peptides can hang out either end of the peptide-binding groove of classical class II molecules, whereas the N and C...
T cell Allorecognition Pathways in Solid Organ Transplantation.
Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; and as self-restricted processed alloantigen...
T cell allorecognition T follicular helper cell chronic allograft vasculopathy cytotoxic CD8 T cells exhaustion Germinal Center indirect presentation Transplantation Dendritic Cells Graft Rejection Histocompatibility Antigens Class II Humans Isoantibodies Isoantigens Organ Transplantation T-Lymphocytes Cytotoxic T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Transplantation Homologous
Metabolomics and Lipidomics Study of Mouse Models of Type 1 Diabetes Highlights Divergent Metabolism in Purine and Tryptophan Metabolism Prior to Disease Onset.
Steven A Murfitt, Paola Zaccone, Xinzhu Wang, Animesh Acharjee, Yvonne Sawyer, Albert Koulman, Lee D Roberts, Anne Cooke, Julian Leether Griffin
Sep 10, 2018
With the increase in incidence of type 1 diabetes (T1DM), there is an urgent need to understand the early molecular and metabolic alterations that accompany the autoimmune disease. This is not least because in murine models...
NOD-severe combined immunodeficiency (SCID) mouse kynurenic acid Mass Spectrometry nonobese diabetic (NOD) mouse xanthinine Animals Autoimmunity Chromatography Liquid Diabetes mellitus Type 1 Discriminant Analysis Disease Models Animal Female Gas Chromatography-Mass Spectrometry Gene Expression Histocompatibility Antigens Class II Islets of Langerhans Kynurenic Acid Lipid Metabolism Lysophospholipids Metabolomics Mice Mice Inbred NOD Mice SCID Mice Transgenic Prediabetic State principal component analysis Protein Multimerization Purines Tryptophan
SpeS
C Coral Dominguez-Medina, Nicola L Rash, Sylvain Robillard, Carl Robinson, Androulla Efstratiou, Karen Broughton, Julian Parkhill, Matthew TG Holden, Maria R Lopez-Alvarez, Romain Paillot, Andrew S Waller
Aug 03, 2020
Bacterial superantigens (sAgs) are powerful activators of the immune response that trigger unspecific T cell responses accompanied by the release of proinflammatory cytokines. Streptococcus equi (S. equi) and Streptococcus...
Streptococcus equi Streptococcus zooepidemicus Adjuvant horse immune response strangles superantigen vaccine Adjuvants Immunologic Antigen Presentation Bacterial Proteins Exotoxins Histocompatibility Antigens Class II Humans Membrane Proteins Meningitis Phylogeny Receptors Antigen T-Cell Streptococcal Infections Streptococcus equi Superantigens vaccines
HLA class I and II expression in oropharyngeal squamous cell carcinoma in relation to tumor HPV status and clinical outcome.
Anders Näsman, Emilia Andersson, Linda Marklund, Nikolaos Tertipis, Lalle Hammarstedt-Nordenvall, Per Attner, Tommy Nyberg, Giuseppe V Masucci, Eva Munck-Wikland, Torbjörn Ramqvist, Tina Dalianis
Jun 08, 2018
HPV-DNA positive (HPVDNA+) oropharyngeal squamous cell carcinoma (OSCC) has better clinical outcome than HPV-DNA negative (HPVDNA-) OSCC. Current treatment may be unnecessarily extensive for most HPV+ OSCC, but before...
Adult Aged Aged 80 and over Carcinoma Squamous Cell Cohort Studies Cyclin-Dependent Kinase Inhibitor p16 DNA Viral Female Gene Expression Regulation Neoplastic HLA Antigens Histocompatibility Antigens Class I Histocompatibility Antigens Class II Humans Male Middle Aged Oropharyngeal Neoplasms Papillomaviridae Prognosis Survival Analysis Treatment Outcome
Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant.
Ines G Harper, Jason M Ali, Simon JF Harper, Elizabeth Wlodek, Jawaher Alsughayyir, Margaret C Negus, M Saeed Qureshi, Reza Motalleb-Zadeh, Kourosh Saeb-Parsy, Eleanor M Bolton, J Andrew Bradley, Menna R Clatworthy, Thomas M Conlon, Gavin J Pettigrew
Mar 18, 2016
Adaptive Immunity Allografts Animals Autoantibodies B-Lymphocytes CD4-Positive T-Lymphocytes Cell Differentiation Graft Rejection Graft vs Host Disease Histocompatibility Antigens Class I Histocompatibility Antigens Class II Immunity Humoral Killer Cells Natural Mice Inbred BALB C Models Immunological Peptides Plasma Cells Receptors Antigen B-Cell Tissue Donors Transplantation Homologous
Chicken cGAS Senses Fowlpox Virus Infection and Regulates Macrophage Effector Functions.
Marisa Oliveira, Damaris Ribeiro Rodrigues, Vanaique Guillory, Emmanuel Kut, Efstathios S Giotis, Michael A Skinner, Rodrigo Guabiraba, Clare E Bryant, Brian J Ferguson
Jan 06, 2021
The anti-viral immune response is dependent on the ability of infected cells to sense foreign nucleic acids. In multiple species, the pattern recognition receptor (PRR) cyclic GMP-AMP synthase (cGAS) senses viral DNA as an...
DNA chicken cyclic GMP-AMP synthase fowlpox MACROPHAGES pattern recognition receptor stimulator of interferon genes Animals Cell Line Chickens DNA Viruses DNA Viral Fowlpox Fowlpox virus Histocompatibility Antigens Class II Interferon Type I MACROPHAGES Membrane Proteins Nucleotides Cyclic Signal Transduction
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants.
Point mutations that affect HLA-DR structure or expression have not previously been described. In the present study, we isolated such mutants by immunoselection of an ethyl methanesulfonate-mutagenized HLA-DR3 cell line with an...
Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes.
Laurence SC Lok, Thomas W Dennison, Krishnaa M Mahbubani, Kourosh Saeb-Parsy, Edwin R Chilvers, Menna R Clatworthy
Sep 05, 2019
FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
PJ Brown, KK Wong, SL Felce, L Lyne, H Spearman, EJ Soilleux, LM Pedersen, MB Møller, TM Green, DM Gascoyne, AH Banham
Dec 17, 2018
The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL). Here microarray analysis of FOXP1-silenced DLBCL cell lines identified differential regulation of immune...
Adult Aged Aged 80 and over Antibodies Monoclonal Murine-Derived Antigens Differentiation B-Lymphocyte Antineoplastic Combined Chemotherapy Protocols B-Lymphocytes cyclophosphamide Doxorubicin Female Forkhead Transcription Factors Gene Expression Regulation Neoplastic Germinal Center HLA-DR alpha-Chains Histocompatibility Antigens Class II Humans Lymphocyte Activation Lymphoma Large B-Cell Diffuse Male Middle Aged Neoplasm Staging Nuclear Proteins prednisone RNA Small Interfering Repressor Proteins Rituximab Signal Transduction Survival Analysis Trans-Activators Vincristine
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.
L Vanderbeke, P Van Mol, Y Van Herck, F De Smet, S Humblet-Baron, K Martinod, A Antoranz, I Arijs, B Boeckx, FM Bosisio, M Casaer, D Dauwe, W De Wever, C Dooms, E Dreesen, A Emmaneel, J Filtjens, M Gouwy, J Gunst, G Hermans, S Jansen, K Lagrou, A Liston, N Lorent, P Meersseman, T Mercier, J Neyts, J Odent, D Panovska, PA Penttila, E Pollet, P Proost, J Qian, K Quintelier, J Raes, S Rex, Y Saeys, J Sprooten, S Tejpar, D Testelmans, K Thevissen, T Van Buyten, J Vandenhaute, S Van Gassen, LC Velásquez Pereira, R Vos, B Weynand, A Wilmer, J Yserbyt, AD Garg, P Matthys, C Wouters, D Lambrechts, E Wauters, J Wauters
Sep 05, 2021
Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the triggering of an aberrant host immune response, more so than on direct virus-induced cellular damage. To elucidate the immunopathology...
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.
Anuradha Tarafdar, Lisa EM Hopcroft, Paolo Gallipoli, Francesca Pellicano, Jennifer Cassels, Alan Hair, Koorosh Korfi, Heather G Jørgensen, David Vetrie, Tessa L Holyoake, Alison M Michie
Aug 16, 2017
Cells Cultured Cytokines Down-Regulation Female Flow Cytometry Gene Expression Regulation Histocompatibility Antigens Class II Humans Leukemia Myelogenous Chronic BCR-ABL Positive Lymphocyte Culture Test Mixed Male Neoplastic Stem Cells Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Tumor Escape