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Results: 14
Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery.
Gonzalo Millan-Zambrano, Helena Santos-Rosa, Fabio Puddu, Samuel C Robson, Stephen P Jackson, Tony Kouzarides
Dec 03, 2018
Cla4 DNA damage checkpoint H4T80ph PAK Rad53 Rad9 Rtt107 Histone modifications Cell Cycle Checkpoints Cell Cycle Proteins Checkpoint Kinase 2 DNA Damage DNA Repair Histones Intracellular Signaling Peptides and Proteins Nuclear Proteins Phosphorylation Protein Binding Protein Serine-Threonine Kinases Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L. Seabra, Miguel Constância, Mariana P. Monteiro
Jul 28, 2021
Background: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.
Lenka Gahurova, Shin-Ichi Tomizawa, Sébastien A Smallwood, Kathleen R Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R Andrews, Taiping Chen, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as...
Studies on the Histone Methyltransferase G9a
Srihari Cidambi Sampath
Jan 01, 0001
The size and complexity of eukaryotic genomes require that specific mechanisms exist for ensuring both the stability as well as the accessibility of DNA. One such mechanism is the association of DNA with histones to form...
Histone modifications G9a methylation G9a protein sequence GLP protein sequence B Cell Development Life Sciences
Published by: Rockefeller University
Uncovering correlated variability in epigenomic datasets using the Karhunen-Loeve transform.
BACKGROUND: Larger variation exists in epigenomes than in genomes, as a single genome shapes the identity of multiple cell types. With the advent of next-generation sequencing, one of the key problems in computational...
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L Seabra, Miguel Constância, Mariana P Monteiro
Aug 26, 2021
Background
Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
obesity DNA Methylation Insulin Resistance Adipose Tissue Type 2 diabetes Histone modifications long non-coding RNAs Dysglycemia
Published by: Frontiers in endocrinology
Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.
Courtney W Hanna, Raquel Pérez-Palacios, Lenka Gahurova, Michael Schubert, Felix Krueger, Laura Biggins, Simon Andrews, Maria Colomé-Tatché, Deborah Bourc'his, Wendy Dean, Gavin Kelsey
Oct 28, 2020
BACKGROUND: Genomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expressed mono-allelically based on the parent of origin and is typically regulated by differential DNA methylation inherited from...
development Embryo Endogenous retroviruses (ERVs) Extra-embryonic Genomic Imprinting H3K27me3 Histone modifications Long terminal repeats (LTRs) Non-canonical imprinting Placenta Animals DNA Methylation Female Genomic Imprinting Histone Code Male Maternal Inheritance Mice Retroviridae Terminal Repeat Sequences
Broad Chromatin Domains
Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or...
H3K27me3 PRC2 chromatin domain Histone modifications Animals Caenorhabditis elegans Chromatin Chromatin Assembly and Disassembly Chromatin Immunoprecipitation Drosophila melanogaster Epigenesis Genetic Genome Histones Lysine Methylation Mice Promoter Regions Genetic Protein Processing Post-Translational
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes.
Kathleen R Stewart, Lenka Veselovska, Jeesun Kim, Jiahao Huang, Heba Saadeh, Shin-Ichi Tomizawa, Sébastien A Smallwood, Taiping Chen, Gavin Kelsey
Jun 24, 2019
Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms underlying DNA methylation establishment remain poorly...
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L Seabra, Miguel Constância, Mariana P Monteiro
Aug 16, 2021
BACKGROUND: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
Viewing AML through a New Lens
Epigenetic modifications, such as histone modifications and DNA methylation, are essential for ensuring the dynamic control of gene regulation in every cell type. These modifications are associated with gene activation or...
Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations.
Jessy Cartier, Thomas Smith, John P Thomson, Catherine M Rose, Batbayar Khulan, Andreas Heger, Richard R Meehan, Amanda J Drake
Sep 08, 2018
BACKGROUND: Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines...
DNA Methylation Early life programming epigenetic Germline transmission Glucocorticoids Histone modifications small RNA Animals Birth Weight DNA Methylation Dexamethasone Epigenesis Genetic Female Glucocorticoids Histone Code Male Maternal Exposure RNA Small Untranslated Rats Sprague-Dawley Spermatozoa