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Results: 39
Network trade-offs and homeostasis in Arabidopsis shoot architectures.
Adam Conn, Arjun Chandrasekhar, Martin van Rongen, Ottoline Leyser, Joanne Chory, Saket Navlakha
Sep 02, 2019
Self-healing codes
As an adaptive system, the brain must retain a faithful representation of the world while continuously integrating new information. Recent experiments have measured population activity in cortical and hippocampal circuits over...
Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Annemarie van Nieuwenhuijze, Oliver Burton, Pierre Lemaitre, Alice E Denton, Ana Cascalho, Rose E Goodchild, Bert Malengier-Devlies, Bénédicte Cauwe, Michelle A Linterman, Stephanie Humblet-Baron, Adrian Liston
Jun 14, 2019
The nucleopore is an essential structure of the eukaryotic cell, regulating passage between the nucleus and cytoplasm. While individual functions of core nucleopore proteins have been identified, the role of other components...
CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Nup210 nucleopore Spleen Thymus Gland Animals CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Female Homeostasis Male Mice Mice Inbred C57BL Mice Knockout Mice Mutant Strains Mutation Nuclear Pore Nuclear Pore Complex Proteins statistics Nonparametric Th1 Cells Th2 Cells Thymocytes Thymus Gland
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
Agatha A van der Klaauw, Sophie Croizier, Edson Mendes de Oliveira, Lukas KJ Stadler, Soyoung Park, Youxin Kong, Matthew C Banton, Panna Tandon, Audrey E Hendricks, Julia M Keogh, Susanna E Riley, Sofia Papadia, Elana Henning, Rebecca Bounds, Elena G Bochukova, Vanisha Mistry, Stephen O'Rahilly, Richard B Simerly, INTERVAL, UK10K consortium, James EN Minchin, Inês Barroso, E Yvonne Jones, Sebastien G Bouret, I Sadaf Farooqi
Jan 29, 2019
Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants...
AGRP Neuropilins Plexins POMC Semaphorin 3s Hypothalamus obesity Adolescent Adult Animals Body Weight Cell Line Child Child Preschool Disease Models Animal Eating Energy Metabolism Female genetic variation Homeostasis Humans Hypothalamus Leptin Male Melanocortins Mice Mice Inbred C57BL Middle Aged Nerve Tissue Proteins Neurons obesity Receptors Cell Surface Semaphorins Young Adult Zebrafish
A Metabolomic Signature of Acute Caloric Restriction
Adult Amino Acids antioxidants Caloric Restriction Carbohydrate Metabolism Chromatography High Pressure Liquid Dehydroepiandrosterone Sulfate Endocannabinoids Energy Metabolism Fatty Acids Homeostasis Humans Lipid Metabolism Lipolysis Male Metabolomics Oxidation-Reduction Steroids Tandem Mass Spectrometry Weight Loss
Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages.
Yuning Lu, Gemma Basatemur, Ian C Scott, Davide Chiarugi, Marc Clement, James Harrison, Ravin Jugdaohsingh, Xian Yu, Stephen A Newland, Helen E Jolin, Xuan Li, Xiao Chen, Monika Szymanska, Guttorm Haraldsen, Gaby Palmer, Padraic G Fallon, E Suzanne Cohen, Andrew NJ McKenzie, Ziad Mallat
Mar 25, 2020
Splenic red pulp macrophages (RPMs) contribute to erythrocyte homeostasis and are required for iron recycling. Heme induces the expression of SPIC transcription factor in monocyte-derived macrophages and promotes their...
erythrophagocytosis Interleukin-33 interleukin-33 receptor Interleukins iron metabolism red pulp macrophage Animals Erythrocytes Heme Homeostasis Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Iron MACROPHAGES Mice Knockout Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Myeloid Differentiation Factor 88 Signal Transduction Spleen
Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis.
Placental energy metabolism in health and disease-significance of development and implications for preeclampsia.
epigenetics fetal growth restriction Glycolysis metabolism Metformin Mitochondria Placenta Preeclampsia Reactive Oxygen Species antioxidants Energy Metabolism Epigenesis Genetic Female Gene Expression Homeostasis Humans Hypoglycemic Agents Metformin Oxidation-Reduction Placenta Placentation pre-eclampsia Pregnancy Reactive Oxygen Species Sex Factors Signal Transduction
Lyplal1 is dispensable for normal fat deposition in mice.
Rachel A Watson, Amy S Gates, Elizabeth H Wynn, Fiona E Calvert, Amandine Girousse, Christopher J Lelliott, Inês Barroso
Jul 25, 2019
Genome-wide association studies (GWAS) have detected association between variants in or near the Lysophospholipase-like 1 (LYPLAL1) locus and metabolic traits, including central obesity, fatty liver and waist-to-hip ratio....
PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1.
Ya Su, Thomas F Hiemstra, Yahui Yan, Juan Li, Hannah I Karet, Lawrence Rosen, Pablo Moreno, Fiona E Karet Frankl
Nov 14, 2016
Adaptor Proteins Signal Transducing Anion Exchange Protein 1 Erythrocyte Cell Membrane Cell Polarity Chlorides Cytoskeleton HEK293 Cells Homeostasis Humans Hydrogen-Ion Concentration Kidney LIM Domain Proteins Multiprotein Complexes Protein Binding Protein Serine-Threonine Kinases Protein Sorting Signals Protein Transport RNA Small Interfering Sodium Bicarbonate
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand.
Ionel Sandovici, Constanze M Hammerle, Sam Virtue, Yurena Vivas-Garcia, Adriana Izquierdo-Lahuerta, Susan E Ozanne, Antonio Vidal-Puig, Gema Medina-Gómez, Miguel Constância
Mar 10, 2021
Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature.
David Reismann, Jonathan Stefanowski, Robert Günther, Asylkhan Rakhymzhan, Romano Matthys, Reto Nützi, Sandra Zehentmeier, Katharina Schmidt-Bleek, Georg Petkau, Hyun-Dong Chang, Sandra Naundorf, York Winter, Fritz Melchers, Georg Duda, Anja E Hauser, Raluca A Niesner
Jun 28, 2019
The bone marrow is a central organ of the immune system, which hosts complex interactions of bone and immune compartments critical for hematopoiesis, immunological memory, and bone regeneration. Although these processes take...
Tunable phenotypic variability through an autoregulatory alternative sigma factor circuit.
Christian P Schwall, Torkel E Loman, Bruno MC Martins, Sandra Cortijo, Casandra Villava, Vassili Kusmartsev, Toby Livesey, Teresa Saez, James CW Locke
Jul 20, 2021
Genetically identical individuals in bacterial populations can display significant phenotypic variability. This variability can be functional, for example by allowing a fraction of stress prepared cells to survive an otherwise...
The cellular composition of the human immune system is shaped by age and cohabitation.
Edward J Carr, James Dooley, Josselyn E Garcia-Perez, Vasiliki Lagou, James C Lee, Carine Wouters, Isabelle Meyts, An Goris, Guy Boeckxstaens, Michelle A Linterman, Adrian Liston
Jun 25, 2019
Detailed population-level description of the human immune system has recently become achievable. We used a 'systems-level' approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high...
Physical and functional links between anion exchanger-1 and sodium pump.
Ya Su, Rafia S Al-Lamki, Katherine G Blake-Palmer, Alison Best, Zoe J Golder, Aiwu Zhou, Fiona E Karet Frankl
Jul 09, 2014
Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
Mitchell J Geer, Johanna P van Geffen, Piraveen Gopalasingam, Timo Vögtle, Christopher W Smith, Silke Heising, Marijke JE Kuijpers, Bibian ME Tullemans, Gavin E Jarvis, Johannes A Eble, Mark Jeeves, Michael Overduin, Johan WM Heemskerk, Alexandra Mazharian, Yotis A Senis
Oct 10, 2018
The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of...
Animals Binding Sites Blood Platelets Homeostasis Mice Mice Inbred C57BL Mice Transgenic Models Molecular Phosphorylation Point Mutation Protein Interaction Maps Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein Tyrosine Phosphatase Non-Receptor Type 6 Receptors Immunologic Signal Transduction Thrombocytopenia src Homology Domains
Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states.
Marianne Stemann Andersen, Edouard Hannezo, Svetlana Ulyanchenko, Soline Estrach, Yasuko Antoku, Sabrina Pisano, Kim E Boonekamp, Sarah Sendrup, Martti Maimets, Marianne Terndrup Pedersen, Jens V Johansen, Ditte L Clement, Chloe C Feral, Benjamin D Simons, Kim B Jensen
Jul 24, 2019
Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics.
Harry L Horsnell, Robert J Tetley, Henry de Belly, Spyridon Makris, Lindsey J Millward, Agnesska C Benjamin, Lucas A Heeringa, Charlotte M de Winde, Ewa K Paluch, Yanlan Mao, Sophie E Acton
Aug 06, 2022
Emergent physical properties of tissues are not readily understood by reductionist studies of their constituent cells. Here, we show molecular signals controlling cellular, physical, and structural properties and collectively...
Using the relationship between brain tissue regional saturation of oxygen and mean arterial pressure to determine the optimal mean arterial pressure in patients following cardiac arrest
Mypinder S Sekhon, Peter Smielewski, Tahara D Bhate, Penelope M Brasher, Denise Foster, David K Menon, Arun K Gupta, Marek Czosnyka, William R Henderson, Kenneth Gin, Graham Wong, Donald E Griesdale
Mar 19, 2019
INTRODUCTION: Prospectively assess cerebral autoregulation and optimal mean arterial pressure (MAPOPT) using the dynamic relationship between MAP and regional saturation of oxygen (rSO2) using near-infrared spectroscopy....
The melanocortin pathway and energy homeostasis
Giles SH Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M Koerperich, Mark D Ericson, Stephanie E Simonds, Courtney M Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger AH Adan
May 24, 2021
BACKGROUND: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in...
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.
Catherine H Wilson, Catriona Crombie, Louise van der Weyden, George Poulogiannis, Alistair G Rust, Mercedes Pardo, Tannia Gracia, Lu Yu, Jyoti Choudhary, Gino B Poulin, Rebecca E McIntyre, Douglas J Winton, H Nikki March, Mark J Arends, Andrew G Fraser, David J Adams
Jan 08, 2019
Genetic screens in simple model organisms have identified many of the key components of the conserved signal transduction pathways that are oncogenic when misregulated. Here, we identify H37N21.1 as a gene that regulates vulval...
Animals Carrier Proteins Cell Differentiation Cell Proliferation Cell Transformation Neoplastic DNA-Binding Proteins Female Gene Deletion Homeostasis Humans Intestines Intracellular Signaling Peptides and Proteins Male Mice Neoplasms Oxidoreductases Prognosis Receptors Cytoplasmic and Nuclear Stem Cells Transcription Factors Tumor Suppressor Proteins Ubiquitination Vesicular Transport Proteins
Published by: EMBO J
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Petros A Tyrakis, Asis Palazon, David Macias, Kian L Lee, Anthony T Phan, Pedro Veliça, Jia You, Grace S Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E Evans, John R Griffiths, Lorenz Poellinger, Ananda W Goldrath, Randall S Johnson
Dec 14, 2016
R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both...
Animals CD8-Positive T-Lymphocytes Cell Differentiation DNA DNA Methylation Dioxygenases Glutarates Histones Homeostasis Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Ketoglutaric Acids Lymphocyte Activation Lysine Mice Oxygen Protein Stability Receptors Antigen T-Cell Von Hippel-Lindau Tumor Suppressor Protein
Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects.
Julika Neumann, Erika Van Nieuwenhove, Lara E Terry, Frederik Staels, Taylor R Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R Baker, Margaux Gerbaux, Mathijs Willemsen, John S Barber, Irina I Serysheva, Liesbeth De Waele, François Vermeulen, Susan Schlenner, Isabelle Meyts, David I Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
Jan 04, 2023
A homozygous mutation in the TUB gene associated with retinal dystrophy and obesity.
Arundhati Dev Borman, Laura R Pearce, Donna S Mackay, Kerstin Nagel-Wolfrum, Alice E Davidson, Robert Henderson, Sumedha Garg, Naushin H Waseem, Andrew R Webster, Vincent Plagnol, Uwe Wolfrum, I Sadaf Farooqi, Anthony T Moore
Mar 17, 2015
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