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Acetyl-CoA Carboxylase Anti-Bacterial Agents Bacterial Proteins Base Sequence Gene Expression Regulation Bacterial Host Factor 1 Protein Macrolides Multigene Family Polyamines Polyenes Pyrroles Serratia Transcription Factors

Acyl-Butyrolactones Antifungal Agents Bacterial Proteins Base Sequence Host Factor 1 Protein Hydroxymethylglutaryl-CoA Synthase Lactones Macrolides Multigene Family Polyketide Synthases Quorum Sensing Sequence Deletion Serratia Sigma Factor

In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) govern translation of numerous transcripts during carbon catabolite repression. Here, Crc was shown to enhance Hfq-mediated...

Bacterial Proteins Host Factor 1 Protein Nucleotide Motifs Protein Biosynthesis Pseudomonas aeruginosa RNA Stability RNA Messenger Repressor Proteins

In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during carbon catabolite repression (CCR). In this regard Crc is required for...

Bacterial Proteins Binding Sites Bordetella pertussis Carbohydrate Metabolism Catabolite Repression Escherichia coli Gene Expression Regulation Bacterial Host Factor 1 Protein Kinetics Models Molecular Nucleotide Motifs Protein Binding Protein Biosynthesis Protein Interaction Domains and Motifs Protein Structure Secondary Pseudomonas aeruginosa RNA Bacterial Regulon Repressor Proteins Transcriptome

Crc RNA chaperone Hfq co-transcriptional RNA folding metabolic regulation ribonucleoprotein assembly translational regulation Ribonucleoproteins Bacterial Proteins Gene Expression Regulation Bacterial RNA Bacterial Host Factor 1 Protein

3′ UTR ArcZ Hfq RNA degradome RNase E RprA TIER-seq Non-coding RNA sRNA maturation uridine ruler 3' Untranslated Regions Bacterial Proteins Catalysis Computational Biology Databases Genetic Endoribonucleases Gene Expression Regulation Bacterial Host Factor 1 Protein Molecular Dynamics Simulation Nucleic Acid Conformation RNA Precursors RNA Bacterial RNA Messenger RNA Small Untranslated Salmonella enterica Structure-Activity Relationship Transcriptome Uridine

The conserved protein Hfq is a key factor in the RNA-mediated control of gene expression in most known bacteria. The transient intermediates Hfq forms with RNA support intricate and robust regulatory networks. In Pseudomonas...

ARN repeats Crc protein Hfq protein RNA metabolism RNA-binding protein dynamic recognition Molecular dynamics protein–nucleic acid interaction Binding Sites Gene Expression Regulation Bacterial Host Factor 1 Protein Nucleic Acid Conformation Nucleotide Motifs Protein Binding Protein Conformation Pseudomonas aeruginosa RNA Bacterial

Polynucleotide phosphorylase (PNPase) is an ancient exoribonuclease conserved in the course of evolution and is found in species as diverse as bacteria and humans. Paradoxically, Escherichia coli PNPase can act not only as an...

Hfq RNA chaperone cryoEM Gene Silencing polynucleotide phosphorylase Ribonuclease ribonucleoprotein complex riboregulation small regulatory RNA Catalytic Domain Endoribonucleases Escherichia coli Escherichia coli Proteins Exoribonucleases Gene Expression Regulation Bacterial Host Factor 1 Protein Molecular Chaperones Polyribonucleotide Nucleotidyltransferase RNA Stability RNA Bacterial RNA Small Untranslated

Caulobacter Hfq RNA–protein interaction natively unstructured protein sRNA Bacterial Proteins Caulobacter crescentus Crystallography X-Ray Host Factor 1 Protein Models Molecular Molecular Chaperones Protein Binding RNA Bacterial RNA Messenger RNA Small Untranslated

In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding, stability, and ribonuclease resistance of RNA, and...

C-terminal domain CsrA Hfq ProQ RNA chaperone RNA metabolism riboregulation Bacteria Bacterial Proteins Gene Expression Regulation Bacterial Host Factor 1 Protein Molecular Chaperones RNA Bacterial RNA Small Untranslated RNA-Binding Proteins

The RNA degradosome is a multi-enzyme assembly that plays a central role in the RNA metabolism of Escherichia coli and numerous other bacterial species including pathogens. At the core of the assembly is the endoribonuclease...

Binding Sites Crystallography X-Ray Endoribonucleases Escherichia coli Proteins Host Factor 1 Protein Models Molecular Multienzyme Complexes Nucleic Acid Conformation Polyribonucleotide Nucleotidyltransferase Protein Binding Protein Domains RNA Helicases RNA Bacterial

Pseudomonas aeruginosa metabolic regulation molecular biophysics riboregulation structural biology Bacterial Proteins Catabolite Repression Cryoelectron Microscopy Gene Expression Regulation Bacterial Host Factor 1 Protein Multiprotein Complexes Peptide Chain Initiation Translational Promoter Regions Genetic Protein Conformation Pseudomonas aeruginosa RNA Bacterial RNA Messenger Repressor Proteins