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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
Pranvera Sadiku, Joseph A Willson, Rebecca S Dickinson, Fiona Murphy, Alison J Harris, Amy Lewis, David Sammut, Ananda S Mirchandani, Eilise Ryan, Emily R Watts, AA Roger Thompson, Helen M Marriott, David H Dockrell, Cormac T Taylor, Martin Schneider, Patrick H Maxwell, Edwin R Chilvers, Massimilliano Mazzone, Veronica Moral, Chris W Pugh, Peter J Ratcliffe, Christopher J Schofield, Bart Ghesquiere, Peter Carmeliet, Moira Kb Whyte, Sarah R Walmsley
Apr 05, 2018
Cardiopulmonary phenotype associated with human PHD2 mutation.
Nick P Talbot, Thomas G Smith, George M Balanos, Keith L Dorrington, Patrick H Maxwell, Peter A Robbins
Oct 10, 2018
Oxygen-dependent regulation of the erythropoietin gene is mediated by the hypoxia-inducible factor (HIF) family of transcription factors. When oxygen is plentiful, HIF undergoes hydroxylation by a family of oxygen-dependent...
Hypoxia hypoxia‐inducible factor prolyl hydroxylase domain protein Pulmonary Circulation ventilation Adult blood pressure cardiac output Echocardiography Doppler Forced Expiratory Volume Heart Rate Humans Hypoxia Hypoxia-Inducible Factor-Proline Dioxygenases Male Mutation Phenotype Polycythemia Spirometry
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.
Jingwei Sim, Andrew S Cowburn, Asis Palazon, Basetti Madhu, Petros A Tyrakis, David Macías, David M Bargiela, Sandra Pietsch, Michael Gralla, Colin E Evans, Thaksaon Kittipassorn, Yu CJ Chey, Cristina M Branco, Helene Rundqvist, Daniel J Peet, Randall S Johnson
Apr 10, 2018
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting...
HIF Hypoxia metabolism Adaptation Physiological Animals Cell Hypoxia Gene Expression Regulation Glycolysis Hypoxia-Inducible Factor-Proline Dioxygenases Male Mice Mice Inbred C57BL Mixed Function Oxygenases Oxygen Oxygen Consumption Procollagen-Proline Dioxygenase Signal Transduction Transcription Genetic Von Hippel-Lindau Tumor Suppressor Protein
Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.
Luise Eckardt, Maria Prange-Barczynska, Emma J Hodson, James W Fielding, Xiaotong Cheng, Joanna DCC Lima, Samvid Kurlekar, Gillian Douglas, Peter J Ratcliffe, Tammie Bishop
Nov 22, 2021
Despite a general role for the HIF hydroxylase system in cellular oxygen sensing and tumour hypoxia, cancer-associated mutations of genes in this pathway, including PHD2, PHD1, EPAS1 (encoding HIF-2α) are highly...
PI(5)P regulates autophagosome biogenesis.
Mariella Vicinanza, Viktor I Korolchuk, Avraham Ashkenazi, Claudia Puri, Fiona M Menzies, Jonathan H Clarke, David C Rubinsztein
Feb 16, 2015
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Atsushi Yamamoto, Joanna Hester, Philip S Macklin, Kento Kawai, Masateru Uchiyama, Daniel Biggs, Tammie Bishop, Katherine Bull, Xiaotong Cheng, Eleanor Cawthorne, Mathew L Coleman, Tanya L Crockford, Ben Davies, Lukas E Dow, Rob Goldin, Kamil Kranc, Hiromi Kudo, Hannah Lawson, James McAuliffe, Kate Milward, Cheryl L Scudamore, Elizabeth Soilleux, Fadi Issa, Peter J Ratcliffe, Chris W Pugh
Dec 20, 2019
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regulate HIFs. Genetic interventions on HIF/PHD pathways reveal multiple phenotypes that extend the known biology of hypoxia. Recent...
Mannose binding lectin is hydroxylated by collagen prolyl-4-hydroxylase and inhibited by some PHD inhibitors
FG-4592 HEK293 Cells PHD inhibitors chronic kidney disease collagen prolyl-4-hydroxylase hypoxia inducible factor mannose binding lectin post-translational Protein Processing renal anemia vadadustat molidustat Collagen Hypoxia-Inducible Factor-Proline Dioxygenases Procollagen-Proline Dioxygenase Prolyl Hydroxylases Prolyl-Hydroxylase Inhibitors
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.
Emma J Hodson, Lynn G Nicholls, Philip J Turner, Ronan Llyr, James W Fielding, Gillian Douglas, Indrika Ratnayaka, Peter A Robbins, Christopher W Pugh, Keith J Buckler, Peter J Ratcliffe, Tammie Bishop
Jun 17, 2019
Ventilatory sensitivity to hypoxia increases in response to continued hypoxic exposure as part of acute acclimatisation. Although this process is incompletely understood, insights have been gained through studies of the...
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
Steve Stegen, Ingrid Stockmans, Karen Moermans, Bernard Theinpont, Patrick H Maxwell, Peter Carmeliet, Geert Carmeliet
Oct 04, 2018
Acetylation Adaptor Proteins Signal Transducing Animals Bone Density Carbazoles Cell Line Coculture Techniques Disease Models Animal Epigenesis Genetic Female Glycoproteins Heterocyclic Compounds 4 or More Rings Humans Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Inducible Factor-Proline Dioxygenases Intercellular Signaling Peptides and Proteins Male Mice Inbred C57BL Mice Transgenic Osteocytes Osteogenesis Osteoporosis Oxygen Primary Cell Culture Promoter Regions Genetic Sirtuin 1 Wnt Signaling Pathway