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Results: 168
Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model.
Jian-Hua Chen, Kim Jee Goh, Nuno Rocha, Matthijs P Groeneveld, Marina Minic, Timothy G Barrett, David Savage, Robert K Semple
May 25, 2018
Adipose tissue is the primary tissue affected in most single gene forms of severe insulin resistance, and growing evidence has implicated it as a site at which many risk alleles for insulin resistance identified in...
Dysglycaemia, Inflammation and Psychosis
Benjamin Ian Perry, Rachel Upthegrove, Andrew Thompson, Steven Marwaha, Stanley Zammit, Swaran Preet Singh, Golam Khandaker
Jun 05, 2018
BACKGROUND: Psychosis is associated with both dysglycaemia and low-grade inflammation, but population-based studies investigating the interplay between these factors are scarce. AIMS: (1) To explore the direction of association...
Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.
Rebecca J Brown, Elif A Oral, Elaine Cochran, David Araújo-Vilar, David B Savage, Alison Long, Gregory Fine, Taylor Salinardi, Phillip Gorden
Jun 18, 2018
PURPOSE: The purpose of this study is to summarize the effectiveness and safety of metreleptin in patients with congenital or acquired generalized lipodystrophy. METHODS: Patients (n = 66) aged ≥6 months had lipodystrophy, low...
Age at Menarche and Blood Pressure in Pregnancy.
Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.
Daniel J Fazakerley, Annabel Y Minard, James R Krycer, Kristen C Thomas, Jacqueline Stöckli, Dylan J Harney, James G Burchfield, Ghassan J Maghzal, Stuart T Caldwell, Richard C Hartley, Roland Stocker, Michael P Murphy, David E James
Jun 28, 2018
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual roles of these processes in insulin resistance has been difficult because they...
MITOCHONDRIAL DYSFUNCTION adipocyte Adipose Tissue Hydrogen Peroxide Insulin Insulin Resistance Mitochondria Muscle Oxidative Stress superoxide ion 3T3-L1 Cells Adenylate Kinase Adipocytes Animals Electron Transport Glucose Glucose Transporter Type 4 Herbicides Hydrogen Peroxide Insulin Insulin Resistance Male Mice Mice Inbred C57BL Mitochondria Myoblasts Oxidative Phosphorylation Oxygen Consumption Paraquat Peroxiredoxins Protein Isoforms Superoxides
AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles
The Danish Diabetes Academy supports JJ with a Visiting Professorship.
Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.
Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C Foukas
Jun 20, 2019
The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that...
Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment.
Ajay Thankamony, Rikke Beck Jensen, Susan M O'Connell, Felix Day, Jeremy Kirk, Malcolm Donaldson, Sten A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Ken K Ong, David B Dunger, Anders Juul
Nov 20, 2015
Absorptiometry Photon Adiposity Body composition Body Height Child Child Preschool Female genetic variation Genotype Glucose Human Growth Hormone Humans Infant Newborn Infant Small for Gestational Age Insulin Insulin Resistance Insulin-Like Growth Factor I Insulin-Secreting Cells Male Pancreatic Function Tests Recombinant Proteins Treatment Outcome
Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children
Eero A Haapala, Petri Wiklund, Niina Lintu, Tuomo Tompuri, Juuso Väistö, Taija Finni, Ina M Tarkka, Titta Kemppainen, Alan R Barker, Ulf Ekelund, Soren Brage, Timo A Lakka
Dec 03, 2019
Increased basal insulin sensitivity in late pregnancy in women carrying a male fetus
BACKGROUND: It has been suggested that fetal sex may be able to modify maternal metabolism and physiology during pregnancy. Recently pregnant women carrying a male fetus were reported to be more insulin sensitive than those...
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L. Seabra, Miguel Constância, Mariana P. Monteiro
Jul 28, 2021
Background: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q.
Anita Ayer, Daniel J Fazakerley, Cacang Suarna, Ghassan J Maghzal, Diba Sheipouri, Kevin J Lee, Michelle C Bradley, Lucía Fernández-Del-Rio, Sergey Tumanov, Stephanie My Kong, Jelske N van der Veen, Andrian Yang, Joshua WK Ho, Steven G Clarke, David E James, Ian W Dawes, Dennis E Vance, Catherine F Clarke, René L Jacobs, Roland Stocker
Nov 25, 2021
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial...
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.
Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Sam Virtue, Stephen O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
Feb 17, 2023
Iron Supplementation in Pregnancy and Risk of Gestational Diabetes
Clive J Petry
Jan 04, 2023
Altered mitochondrial metabolism in the insulin-resistant heart.
Marina Makrecka-Kuka, Edgars Liepinsh, Andrew J Murray, Hélène Lemieux, Maija Dambrova, Kersti Tepp, Marju Puurand, Tuuli Käämbre, Woo H Han, Paul de Goede, Katie A O'Brien, Belma Turan, Erkan Tuncay, Yusuf Olgar, Anabela P Rolo, Carlos M Palmeira, Neoma T Boardman, Rob CI Wüst, Terje S Larsen
Dec 11, 2019
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.
Michelle Goldsworthy, Nathan L Absalom, David Schröter, Helen C Matthews, Debora Bogani, Lee Moir, Anna Long, Christopher Church, Alison Hugill, Quentin M Anstee, Rob Goldin, Mark Thursz, Florian Hollfelder, Roger D Cox
Jan 22, 2021
We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type...
Differential effects of exposure to maternal obesity or maternal weight loss during the periconceptional period in the sheep on insulin signalling molecules in skeletal muscle of the offspring at 4 months of age.
Lisa M Nicholas, Janna L Morrison, Leewen Rattanatray, Susan E Ozanne, Dave O Kleemann, Simon K Walker, Severence M MacLaughlin, Song Zhang, Malgorzata S Martin-Gronert, Isabella C McMillen
Aug 12, 2020
Exposure to maternal obesity before and/or throughout pregnancy may increase the risk of obesity and insulin resistance in the offspring in childhood and adult life, therefore, resulting in its transmission into subsequent...
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment.
Henk-Jan van den Ham, Jason D Cooper, Jakub Tomasik, Sabine Bahn, Joeri L Aerts, Albert DME Osterhaus, Rob A Gruters, Arno C Andeweg, DC-TRN trial investigators
May 23, 2018
OBJECTIVES: To characterize the host response to dendritic cell-based immunotherapy and subsequent combined antiretroviral therapy (cART) interruption in HIV-1-infected individuals at the plasma protein level. DESIGN: An...
AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome
MW O'Reilly, P Kempegowda, M Walsh, AE Taylor, K Manolopoulos, JW Allwood, RK Semple, D Hebenstreit, WB Dunn, JW Tomlinson, W Arlt
Aug 29, 2017
3-Hydroxysteroid Dehydrogenases Adipocytes Adolescent Adult Aldo-Keto Reductase Family 1 Member C3 Analysis of Variance Androgens Area Under Curve Biomarkers Case-Control Studies Cells Cultured Dehydroepiandrosterone Female Humans Hydroxyprostaglandin Dehydrogenases Insulin Resistance Lipid Metabolism Lipolysis POLYCYSTIC OVARY SYNDROME Real-Time Polymerase Chain Reaction Reference Values statistics Nonparametric Subcutaneous Fat Young Adult
Effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose-insulin dynamics in young adult horses.
Alterations in whole-body insulin sensitivity resulting from repeated eccentric exercise of a single muscle group
Unaccustomed eccentric exercise using large muscle groups elicits soreness, decrements in physical function and impairs markers of whole-body insulin sensitivity; although these effects are attenuated with a repeated exposure....
Liver Function and Risk of Type 2 Diabetes
N Maneka G De Silva, Maria Carolina Borges, Aroon D Hingorani, Jorgen Engmann, Tina Shah, Xiaoshuai Zhang, Jian'an Luan, Claudia Langenberg, Andrew Wong, Diana Kuh, John C Chambers, Weihua Zhang, Marjo-Ritta Jarvelin, Sylvain Sebert, Juha Auvinen, UCLEB Consortium, Tom R Gaunt, Deborah A Lawlor
May 15, 2019
Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial.
Peter J Curtis, Vera van der Velpen, Lindsey Berends, Amy Jennings, Martin Feelisch, A Margot Umpleby, Mark Evans, Bernadette O Fernandez, Mia S Meiss, Magdalena Minnion, John Potter, Anne-Marie Minihane, Colin D Kay, Eric B Rimm, Aedín Cassidy
Jan 28, 2019
Metabolic Syndrome blueberry anthocyanins Flavonoids cardiovascular disease risk anthocyanin-derived phenolic acid metabolites Aged Apolipoproteins Biomarkers blood pressure Blueberry Plants Cholesterol HDL Cholesterol LDL Double-Blind Method Female Fruit Heart Humans Insulin Resistance Male Metabolic Syndrome Middle Aged Prospective Studies Pulse Wave Analysis
A multi-stage drop-the-losers design for multi-arm clinical trials.
Multi-arm multi-stage trials can improve the efficiency of the drug development process when multiple new treatments are available for testing. A group-sequential approach can be used in order to design multi-arm multi-stage...
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