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Results: 32
Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
Cai Read, Peiran Yang, Rhoda E Kuc, Duuamene Nyimanu, Thomas L Williams, Robert C Glen, Lucy J Holt, Haren Arulanantham, Andrew Smart, Anthony P Davenport, Janet J Maguire
Mar 21, 2019
DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.
Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B Pinnock, Sacri R Ferrón, Antonio Vidal-Puig, Anne C Ferguson-Smith
Nov 13, 2014
Progranulin plasma levels predict the presence of GRN mutations in asymptomatic subjects and do not correlate with brain atrophy
Daniela Galimberti, Giorgio G Fumagalli, Chiara Fenoglio, Sara MG Cioffi, Andrea Arighi, Maria Serpente, Barbara Borroni, Alessandro Padovani, Fabrizio Tagliavini, Mario Masellis, Maria Carmela Tartaglia, John van Swieten, Lieke Meeter, Caroline Graff, Alexandre de Mendonça, Martina Bocchetta, Jonathan D Rohrer, Elio Scarpini, Genetic FTD Initiative (GENFI)
May 14, 2018
We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic...
biomarker brain atrophy frontotemporal dementia (FTD) Plasma levels Progranulin (GRN) Proximity marker Adult Aged Aged 80 and over Atrophy Cohort Studies Female frontotemporal dementia Genetic Association Studies Genetic Testing Gray Matter Heterozygote Humans Intercellular Signaling Peptides and Proteins Male Membrane Proteins Middle Aged Multicenter Studies as Topic Mutation Nerve Tissue Proteins Progranulins Sensitivity and Specificity Young Adult
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Alison P Klein, Brian M Wolpin, Harvey A Risch, Rachael Z Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J Childs, Jason W Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A Arslan, Ana Babic, William R Bamlet, Laura Beane-Freeman, Sonja I Berndt, Amanda Blackford, Michael Borges, Ayelet Borgida, Paige M Bracci, Lauren Brais, Paul Brennan, Hermann Brenner, Bas Bueno-de-Mesquita, Julie Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G Chaffee, Charles C Chung, Sean Cleary, Michelle Cotterchio, Frederike Dijk, Eric J Duell, Lenka Foretova, Charles Fuchs, Niccola Funel, Steven Gallinger, J Michael M Gaziano, Maria Gazouli, Graham G Giles, Edward Giovannucci, Michael Goggins, Gary E Goodman, Phyllis J Goodman, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Peter Hegyi, Kathy J Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A Holly, Robert Hoover, Rayjean J Hung, Eric J Jacobs, Krzysztof Jamroziak, Vladimir Janout, Rudolf Kaaks, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H Kulke, Juozas Kupcinskas, Robert J Kurtz, Daniel Laheru, Stefano Landi, Rita T Lawlor, I-Min Lee, Loic Lemarchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Mannisto, Roger L Milne, Beatrice Mohelníková-Duchoňová, Rachel E Neale, John P Neoptolemos, Ann L Oberg, Sara H Olson, Irene Orlow, Claudio Pasquali, Alpa V Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X Real, Nathaniel Rothman, Ghislaine Scelo, Howard D Sesso, Gianluca Severi, Xiao-Ou Shu, Debra Silverman, Jill P Smith, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Francesca Tavano, Mark D Thornquist, Geoffrey S Tobias, Stephen K Van Den Eeden, Yogesh Vashist, Kala Visvanathan, Pavel Vodicka, Jean Wactawski-Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen Chanock, Ofure Obazee, Gloria M Petersen, Laufey T Amundadottir
Jul 31, 2018
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040...
Carcinoma Pancreatic Ductal Databases Genetic Genetic Predisposition to Disease Genome-Wide Association Study Hepatocyte Nuclear Factor 1-beta Hepatocyte Nuclear Factor 4 Humans Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Pancreatic Neoplasms Polymorphism Single Nucleotide Proteins Repressor Proteins Tensins
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients
Esther M de Kruijf, Anita Sajet, Johanna GH van Nes, Hein Putter, Vincent THBM Smit, Robert A Eagle, Insiya Jafferji, John Trowsdale, Gerrit Jan Liefers, Cornelis JH van de Velde, Peter JK Kuppen
Mar 02, 2012
White matter hyperintensities are seen only inGRNmutation carriers in the GENFI cohort.
Carole H Sudre, Martina Bocchetta, David Cash, David L Thomas, Ione Woollacott, Katrina M Dick, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Sébastien Ourselin, M Jorge Cardoso, Jonathan D Rohrer, GENFI Genetic FTD Initiative
Nov 23, 2017
Genetic frontotemporal dementia is most commonly caused by mutations in the progranulin(GRN), microtubule-associated protein tau (MAPT)and chromosome 9 open reading frame 72(C9orf72) genes. Previous small studies have reported...
CI Confidence interval FTD Frontotemporal dementia IQR Inter Quartile Range PS Presymptomatic S Symptomatic TIV Total Intracranial volume WMH White matter hyperintensity Adult Aged C9orf72 Protein Cohort Studies Female frontotemporal dementia Humans Intercellular Signaling Peptides and Proteins Magnetic Resonance Imaging Male Middle Aged white matter tau Proteins
Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment.
Antonio J Pagán, Chao-Tsung Yang, James Cameron, Laura E Swaim, Felix Ellett, Graham J Lieschke, Lalita Ramakrishnan
Jun 26, 2015
Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.
Sacri R Ferrón, Marika Charalambous, Elizabeth Radford, Kirsten McEwen, Hendrik Wildner, Eleanor Hind, Jose Manuel Morante-Redolat, Jorge Laborda, Francois Guillemot, Steven R Bauer, Isabel Fariñas, Anne C Ferguson-Smith
Apr 09, 2019
The gene for the atypical NOTCH ligand delta-like homologue 1 (Dlk1) encodes membrane-bound and secreted isoforms that function in several developmental processes in vitro and in vivo. Dlk1, a member of a cluster of imprinted...
aging Animals Animals Newborn Astrocytes Base Sequence Calcium-Binding Proteins Cell Membrane Cells Cultured Embryo Mammalian Female Genomic Imprinting Genotype Intercellular Signaling Peptides and Proteins Male Mice Mice Inbred C57BL Neural Stem Cells Neurogenesis Olfactory Bulb Protein Isoforms Stem Cell Niche
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
John RB Perry, Felix Day, Cathy E Elks, Patrick Sulem, Deborah J Thompson, Teresa Ferreira, Chunyan He, Daniel I Chasman, Tõnu Esko, Gudmar Thorleifsson, Eva Albrecht, Wei Q Ang, Tanguy Corre, Diana L Cousminer, Bjarke Feenstra, Nora Franceschini, Andrea Ganna, Andrew D Johnson, Sanela Kjellqvist, Kathryn L Lunetta, George McMahon, Ilja M Nolte, Lavinia Paternoster, Eleonora Porcu, Albert V Smith, Lisette Stolk, Alexander Teumer, Natalia Tšernikova, Emmi Tikkanen, Sheila Ulivi, Erin K Wagner, Najaf Amin, Laura J Bierut, Enda M Byrne, Jouke-Jan Hottenga, Daniel L Koller, Massimo Mangino, Tune H Pers, Laura M Yerges-Armstrong, Jing Hua Zhao, Irene L Andrulis, Hoda Anton-Culver, Femke Atsma, Stefania Bandinelli, Matthias W Beckmann, Javier Benitez, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Hiltrud Brauch, Hermann Brenner, Julie E Buring, Jenny Chang-Claude, Stephen Chanock, Jinhui Chen, Georgia Chenevix-Trench, J Margriet Collée, Fergus J Couch, David Couper, Andrea D Coveillo, Angela Cox, Kamila Czene, Adamo Pio d'Adamo, George Davey Smith, Immaculata De Vivo, Ellen W Demerath, Joe Dennis, Peter Devilee, Aida K Dieffenbach, Alison M Dunning, Gudny Eiriksdottir, Johan G Eriksson, Peter A Fasching, Luigi Ferrucci, Dieter Flesch-Janys, Henrik Flyger, Tatiana Foroud, Lude Franke, Melissa E Garcia, Montserrat García-Closas, Frank Geller, Eco Ej de Geus, Graham G Giles, Daniel F Gudbjartsson, Vilmundur Gudnason, Pascal Guénel, Suiqun Guo, Per Hall, Ute Hamann, Robin Haring, Catharina A Hartman, Andrew C Heath, Albert Hofman, Maartje J Hooning, John L Hopper, Frank B Hu, David J Hunter, David Karasik, Douglas P Kiel, Julia A Knight, Veli-Matti Kosma, Zoltan Kutalik, Sandra Lai, Diether Lambrechts, Annika Lindblom, Reedik Mägi, Patrik K Magnusson, Arto Mannermaa, Nicholas G Martin, Gisli Masson, Patrick F McArdle, Wendy L McArdle, Mads Melbye, Kyriaki Michailidou, Evelin Mihailov, Lili Milani, Roger L Milne, Heli Nevanlinna, Patrick Neven, Ellen A Nohr, Albertine J Oldehinkel, Ben A Oostra, Aarno Palotie, Munro Peacock, Nancy L Pedersen, Paolo Peterlongo, Julian Peto, Paul DP Pharoah, Dirkje S Postma, Anneli Pouta, Katri Pylkäs, Paolo Radice, Susan Ring, Fernando Rivadeneira, Antonietta Robino, Lynda M Rose, Anja Rudolph, Veikko Salomaa, Serena Sanna, David Schlessinger, Marjanka K Schmidt, Mellissa C Southey, Ulla Sovio, Meir J Stampfer, Doris Stöckl, Anna M Storniolo, Nicholas J Timpson, Jonathan Tyrer, Jenny A Visser, Peter Vollenweider, Henry Völzke, Gerard Waeber, Melanie Waldenberger, Henri Wallaschofski, Qin Wang, Gonneke Willemsen, Robert Winqvist, Bruce Hr Wolffenbuttel, Margaret J Wright, Australian Ovarian Cancer Study, GENICA Network, kConFab, Lifelines Cohort Study, InterAct Consortium, Early Growth Genetics (EGG) Consortium, Dorret I Boomsma, Michael J Econs, Kay-Tee Khaw, Ruth JF Loos, Mark I McCarthy, Grant W Montgomery, John P Rice, Elizabeth A Streeten, Unnur Thorsteinsdottir, Cornelia M van Duijn, Behrooz Z Alizadeh, Sven Bergmann, Eric Boerwinkle, Heather A Boyd, Laura Crisponi, Paolo Gasparini, Christian Gieger, Tamara B Harris, Erik Ingelsson, Marjo-Riitta Järvelin, Peter Kraft, Debbie Lawlor, Andres Metspalu, Craig E Pennell, Paul M Ridker, Harold Snieder, Thorkild IA Sørensen, Tim D Spector, David P Strachan, André G Uitterlinden, Nicholas J Wareham, Elisabeth Widen, Marek Zygmunt, Anna Murray, Douglas F Easton, Kari Stefansson, Joanne M Murabito, Ken K Ong
Jan 23, 2018
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and...
Adolescent Age Factors Alleles Body Mass Index Breast Neoplasms Calcium-Binding Proteins Cardiovascular Diseases Child Diabetes mellitus Type 2 Europe Female Genetic Loci Genome-Wide Association Study Genomic Imprinting Humans Hypothalamo-Hypophyseal System Intercellular Signaling Peptides and Proteins Male Membrane Proteins Menarche obesity Ovary Parents Polymorphism Single Nucleotide Potassium Channels Tandem Pore Domain Proteins Quantitative Trait Loci Receptors GABA-B Receptors Retinoic Acid Ribonucleoproteins Ubiquitin-Protein Ligases
Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists.
Ana-Luisa Silva, Sarah N Dawson, Mark J Arends, Kiran Guttula, Nigel Hall, Ewen A Cameron, Tim H-M Huang, James D Brenton, Simon Tavaré, Mariann Bienz, Ashraf EK Ibrahim
Feb 10, 2015
Structure of Gremlin-1 and analysis of its interaction with BMP-2.
Gremlin X-ray crystallography Bone Morphogenetic Protein (BMP) differential screening-aberrative in neuroblastoma (DAN) extracellular antagonism structural biology transforming growth factor-β (TGF-β) Bone Morphogenetic Protein 2 Carrier Proteins Crystallography X-Ray Glycoproteins Humans Intercellular Signaling Peptides and Proteins Mutation Protein Binding Protein Conformation Protein Multimerization Signal Transduction
Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction.
Mary AM Cleaton, Claire L Dent, Mark Howard, Jennifer A Corish, Isabelle Gutteridge, Ulla Sovio, Francesca Gaccioli, Nozomi Takahashi, Steven R Bauer, D Steven Charnock-Jones, Theresa L Powell, Gordon CS Smith, Anne C Ferguson-Smith, Marika Charalambous
Nov 22, 2016
Yoda1 and phosphatidylserine exposure in red cells from patients with sickle cell anaemia.
ADA2 deficiency complicated by EBV-driven lymphoproliferative disease.
Emily Staples, Ilenia Simeoni, Jonathan C Stephens, Hana Lango Allen, NIHR-BioResource, Penny Wright, E Graham Davies, Babak Javid, Effrossyni Gkrania-Klotsas, Michael Gattens, Helen Firth, Olga Shamardina, Sri VV Deevi, Matina Prapa, Ben Uttenthal, Dinakantha Kumararatne, James ED Thaventhiran
May 14, 2020
A 29-year old male with recurrent respiratory and skin infections, anaemia and neutropaenia during childhood required immunoglobulin replacement for antibody deficiency from age 16. He remained relatively well until age 28 when...
IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction.
Sjoerd D Joustra, Ferdinand Roelfsema, AS Paul van Trotsenburg, Harald J Schneider, Robert P Kosilek, Herman M Kroon, John G Logan, Natalie C Butterfield, Xiang Zhou, Chirine Toufaily, Beata Bak, Marc-Olivier Turgeon, Emilie Brûlé, Frederik J Steyn, Mark Gurnell, Olympia Koulouri, Paul Le Tissier, Pierre Fontanaud, JH Duncan Bassett, Graham R Williams, Wilma Oostdijk, Jan M Wit, Alberto M Pereira, Nienke R Biermasz, Daniel J Bernard, Nadia Schoenmakers
Sep 23, 2019
Synthetic chemerin-derived peptides suppress inflammation through ChemR23.
Jenna L Cash, Rosie Hart, Andreas Russ, John PC Dixon, William H Colledge, Joanne Doran, Alan G Hendrick, Mark BL Carlton, David R Greaves
Jan 02, 2020
Chemerin is a chemotactic protein that binds to the G protein-coupled receptor, ChemR23. We demonstrate that murine chemerin possesses potent antiinflammatory properties that are absolutely dependent on proteolytic processing. A...
Animals Anti-Inflammatory Agents Antibodies Chemokines Chemotactic Factors Chemotaxis Inflammation Intercellular Signaling Peptides and Proteins Macrophage Activation MACROPHAGES Peritoneal Mice Mice Inbred C57BL Neutralization Tests Peptides Peritonitis Protein Processing Post-Translational Receptors Chemokine Receptors G-Protein-Coupled Zymosan
Organoid culture media formulated with growth factors of defined cellular activity.
Manuela Urbischek, Helena Rannikmae, Thomas Foets, Katharina Ravn, Marko Hyvönen, Marc de la Roche
Apr 15, 2019
The media formulations necessary for deriving and sustaining organoids from epithelial tissues such as prostate, colon, gastric, liver, pancreas, and others have been established. Critical components of organoid media are a set...
Rare variants in axonogenesis genes connect three families with sound-color synesthesia.
Amanda K Tilot, Katerina S Kucera, Arianna Vino, Julian E Asher, Simon Baron-Cohen, Simon E Fisher
May 09, 2019
Synesthesia is a rare nonpathological phenomenon where stimulation of one sense automatically provokes a secondary perception in another. Hypothesized to result from differences in cortical wiring during development, synesthetes...
axonogenesis Perception Synaesthesia Synesthesia whole-exome sequencing Auditory Perception Axons Collagen Type IV Color Perception Female Gene Expression genetic variation Humans Integrin alpha2 Intercellular Signaling Peptides and Proteins Male Myosins Nerve Tissue Proteins Pedigree Perceptual Disorders RGS Proteins Receptors Cell Surface Receptors Immunologic Sodium-Hydrogen Exchangers Synesthesia
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers.
Francesca Gaccioli, Irving LMH Aye, Ulla Sovio, D Stephen Charnock-Jones, Gordon CS Smith
Mar 29, 2018
Fetal growth restriction is a major determinant of perinatal morbidity and mortality. Screening for fetal growth restriction is a key element of prenatal care but it is recognized to be problematic. Screening using clinical risk...
A-disintegrin and metalloprotease 12 alpha fetoprotein biomarker fetal biometry Fetal Death human chorionic gonadotropin human placental lactogen inhibin Models Placenta placental growth factor placental protein 13 PREDICTION Pregnancy-Associated Plasma Protein-A Randomized controlled trial Review screening Small for gestational age soluble endoglin soluble fms-like tyrosine kinase-1 Stillbirth study design ULTRASOUND ADAM12 Protein Biomarkers Biometry Calcium-Binding Proteins Chorionic Gonadotropin Endoglin Estriol Female Fetal Growth Retardation Galectins Humans Inhibins Intercellular Signaling Peptides and Proteins Laser-Doppler Flowmetry Membrane Proteins Placenta Growth Factor Placental Circulation Placental Lactogen Pregnancy Pregnancy Proteins Pregnancy-Associated Plasma Protein-A Prenatal Diagnosis Ultrasonography Prenatal Vascular Endothelial Growth Factor Receptor-1 alpha-Fetoproteins
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
Lidia Wrobel, Farah H Siddiqi, Sandra M Hill, Sung Min Son, Cansu Karabiyik, Hyunjeong Kim, David C Rubinsztein
Jan 19, 2021
The mechanistic target of rapamycin complex 2 (mTORC2) controls cell metabolism and survival in response to environmental inputs. Dysregulation of mTORC2 signaling has been linked to diverse human diseases, including cancer and...
RICTOR USP9X growth factor signaling mTORC2 Mechanistic Target of Rapamycin Complex 2 posttranslational modification ubiquitin-specific protease 9X Animals Cell Line Tumor Female Gene Expression Regulation Gene Knockdown Techniques HEK293 Cells HeLa Cells Humans Intercellular Signaling Peptides and Proteins Male Mechanistic Target of Rapamycin Complex 2 Mice Mice Inbred C57BL Protein Binding Protein Processing Post-Translational Rapamycin-Insensitive Companion of mTOR Protein Signal Transduction Ubiquitin Thiolesterase Ubiquitination
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Duuamene Nyimanu, Richard G Kay, Petra Sulentic, Rhoda E Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M Gribble, Joseph Cheriyan, Janet J Maguire, Anthony P Davenport
Dec 05, 2019
[Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its stability...
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation.
Martin Baumdick, Márton Gelléri, Chayasith Uttamapinant, Václav Beránek, Jason W Chin, Philippe IH Bastiaens
Feb 07, 2019
Epidermal growth factor receptor (EGFR) activation by growth factors (GFs) relies on dimerization and allosteric activation of its intrinsic kinase activity, resulting in trans-phosphorylation of tyrosines on its C-terminal...
Pharmacological targeting of apelin impairs glioblastoma growth
E Harford-Wright, G Andre-Gregoire, KA Jacobs, L Treps, S Le Gonidec, HM Leclair, S Gonzalez-Diest, Q Roux, F Guillonneau, D Loussouarn, L Oliver, FM Vallette, F Foufelle, P Valet, AP Davenport, RC Glen, N Bidere, J Gavard
Aug 04, 2017
APJ Antagonist apelin glioblastoma initiating cells vascular niche Animals apelin Apelin Receptors Brain Neoplasms Cell Proliferation Cell Survival Endothelial Cells Glioblastoma HEK293 Cells Humans In Vitro Techniques Intercellular Signaling Peptides and Proteins Mass Spectrometry Mice Molecular Targeted Therapy Proteomics RNA Small Interfering Receptors G-Protein-Coupled Xenograft Model Antitumor Assays
The Use of Growth Factors and Mesenchymal Stem Cells in Orthopaedics: In particular, their use in Fractures and Non-Unions
AIM: The aim was to look at current evidence for treating non-unions or delayed fracture healing in regard to novel methods applying mesenchymal stem cells (MSCs) and growth factors (GF). METHODS: Pre-clinical and clinical...
Bone Morphogenetic Proteins Fracture growth factor Mesenchymal Stem Cells non-union Orthopaedics vascular
endothelial growth factor Animals Bone Regeneration Cell Differentiation Fracture Healing Fractures Bone Guided Tissue Regeneration Humans Intercellular Signaling Peptides and Proteins Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Orthopedics
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