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RATIONALE: Despite an established role for adaptive immune responses in atherosclerosis, the contribution of dendritic cells (DCs) and their various subsets is still poorly understood. OBJECTIVE: Here, we address the role of...

Atherosclerosis Dendritic Cells Immune System Lymphocytes Mice Adaptive Immunity Animals Aorta Atherosclerosis CD11 Antigens Cells Cultured Dendritic Cells Diet High-Fat Female Histocompatibility Antigens Class II Interferon Regulatory Factors Male Mice Mice Inbred C57BL T-Lymphocytes

IRF5 Dendritic Cells iPSCs Inflammation Influenza Adaptive Immunity Animals Disease Models Animal Host-Pathogen Interactions Humans Immunity Innate Induced Pluripotent Stem Cells Influenza A virus Influenza Human Interferon Regulatory Factors Interferon Type I Lung MACROPHAGES Mice Orthomyxoviridae Infections Virus Replication

The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the...

CyTOF IRF8 dendritic cell Hematopoiesis Immunity primary immunodeficiency single-cell RNA sequencing Transcription factor Animals Antigens CD1 Antigens CD34 Cell Line Cell Lineage Dendritic Cells Glycoproteins Hematopoiesis Hematopoietic Stem Cells Humans Interferon Regulatory Factors Interleukin-3 Receptor alpha Subunit Lipopolysaccharide Receptors Mice Receptors Immunologic

Phosphoinositide-3 kinase (PI3K) signaling is important for the survival of numerous cell types and class IA of PI3K is specifically required for the development of B cells but not for T cell development. Here, we show that...

Adaptor Proteins Signal Transducing Animals Antigens CD19 B-Lymphocytes Cell Line Cell Lineage Cells Cultured Forkhead Box Protein O1 Interferon Regulatory Factors lymphopoiesis Mice PAX5 Transcription Factor Phosphatidylinositol 3-Kinases

Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but precise interspecies correlation is currently incomplete. Here, we showed that murine lung and gut lamina propria CD11b+ DC populations...

Animals Aspergillus fumigatus CD11b Antigen CD24 Antigen Cell Differentiation Dendritic Cells Humans Interferon Regulatory Factors Interleukin-17 Interleukin-23 Intestinal Mucosa MACROPHAGES Mice Receptors IgG Respiratory Mucosa Th17 Cells fms-Like Tyrosine Kinase 3

Animals Cell Self Renewal Cellular Reprogramming Cytokines Granulocyte-Macrophage Progenitor Cells Granulocytes Interferon Regulatory Factors Leukemia MACROPHAGES Mice Molecular Imaging Myelopoiesis Neoplastic Stem Cells Stem Cell Niche beta Catenin

The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We...

Carrier Proteins Cytochrome P-450 CYP1B1 Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Group VI Phospholipases A2 Guanine Nucleotide Exchange Factors Histone Deacetylases Humans Interferon Regulatory Factors Melanoma MicroRNAs Microfilament Proteins Nerve Tissue Proteins Nevus Pigmented Nuclear Proteins Polymorphism Single Nucleotide RNA RNA-Binding Proteins Receptors G-Protein-Coupled Repressor Proteins Skin Neoplasms Stem Cell Factor Telomerase Telomere-Binding Proteins White People

Animals B-Lymphocytes Butyrate Response Factor 1 Cell Adhesion Cell Movement Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Gene Expression Regulation High-Throughput Nucleotide Sequencing Interferon Regulatory Factors Kruppel-Like Transcription Factors Lymphoid Tissue Mice Nuclear Proteins Phenotype RNA-Binding Proteins Real-Time Polymerase Chain Reaction Sequence Analysis RNA Signal Transduction