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Results: 29
Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias.
Eleanor King, John Tiernan O'Brien, Paul Donaghy, Christopher Morris, Nicola Barnett, Kirsty Olsen, Carmen Martin-Ruiz, John-Paul Taylor, Alan J Thomas
Jan 29, 2018
Aged Aged 80 and over Alzheimer Disease C-Reactive Protein Case-Control Studies Cognitive Dysfunction Cytokines Female Humans Inflammation Interferon-gamma Interleukin-10 Interleukin-12 Interleukin-13 Interleukin-1beta Interleukin-2 Interleukin-4 Interleukin-6 Interleukin-8 Lewy Body Disease Male Prodromal Symptoms Tumor Necrosis Factor-alpha
Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals.
Balakrishnan Chakrapani Narmada, Yeek Teck Goh, Huan Li, Sanjay Sinha, Hanry Yu, Christine Cheung
Feb 07, 2019
Atherosclerosis underlies many cardiovascular and cerebrovascular diseases. Nutraceuticals are emerging as a therapeutic moiety for restoring vascular health. Unlike small-molecule drugs, the complexity of ingredients in...
Coculture Endothelial Cells Hepatocytes Human pluripotent stem cells metabolism Nutraceutical testing Culture Media Conditioned Dietary Supplements endothelial progenitor cells Genistein Hepatocytes Human Embryonic Stem Cells Humans Inflammation Interleukin-1beta Liver Metabolome Pluripotent Stem Cells Protective Agents Quercetin
Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.
Si Ming Man, Andrew Ekpenyong, Panagiotis Tourlomousis, Sarra Achouri, Eugenia Cammarota, Katherine Hughes, Alessandro Rizzo, Gilbert Ng, John A Wright, Pietro Cicuta, Jochen R Guck, Clare E Bryant
Feb 03, 2015
ASC ROS caspase-1 Cytoskeleton innate immunity Actin Cytoskeleton Actins Animals Apoptosis Regulatory Proteins Bone Marrow Cells Calcium-Binding Proteins Caspase 1 Cytoskeleton Hydrogen Peroxide Immunity Innate Inflammasomes Inflammation Interleukin-1beta MACROPHAGES Mice Mice Transgenic Microscopy Confocal Neutrophils Polymerization Reactive Oxygen Species Salmonella Infections Salmonella typhimurium
TGFβ (Transforming Growth Factor-β) Blockade Induces a Human-Like Disease in a Nondissecting Mouse Model of Abdominal Aortic Aneurysm.
Fabien Lareyre, Marc Clément, Juliette Raffort, Stefanie Pohlod, Meghana Patel, Bruno Esposito, Leanne Master, Alison Finigan, Marie Vandestienne, Nikolaos Stergiopulos, Soraya Taleb, Bram Trachet, Ziad Mallat
Mar 19, 2019
OBJECTIVE: Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGFβ (transforming growth factor-β) activity-a guardian of...
Aneurysm Animals Humans Immune System Models Animals Antibodies Monoclonal Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Apolipoproteins E Chemotaxis Leukocyte Dilatation Pathologic Disease Models Animal Disease Progression Extracellular Matrix Interleukin-1beta Kinetics Male Mice Inbred C57BL Mice Knockout Pancreatic Elastase Synchrotrons Thrombosis Transforming Growth Factor beta Ultrasonography Vascular Remodeling Wound Healing
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis.
Chenzhi Jing, Tomas Castro-Dopico, Nathan Richoz, Zewen K Tuong, John R Ferdinand, Laurence SC Lok, Kevin W Loudon, Gemma D Banham, Rebeccah J Mathews, Zaeem Cader, Susan Fitzpatrick, Kathleen R Bashant, Mariana J Kaplan, Arthur Kaser, Randall S Johnson, Michael P Murphy, Richard M Siegel, Menna R Clatworthy
May 20, 2020
IgG antibodies cause inflammation and organ damage in autoimmune diseases such as systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages isolated from inflamed tissues in immune complex...
Fcγ receptors Lupus Nephritis metabolism Animals Cells Cultured Cellular Reprogramming Dinoprostone Energy Metabolism Gene Expression Regulation Glycolysis Humans Immunoglobulin G Interleukin-1beta Kidney Lupus Nephritis MACROPHAGES Mice Mice Inbred C57BL Mice Knockout Reactive Oxygen Species Receptors IgG
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Jennifer K Dowling, Remsha Afzal, Linden J Gearing, Mariana P Cervantes-Silva, Stephanie Annett, Gavin M Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J Gough, Glenn R Bantug, Fidinny I Hamid, Frances K Nally, Conor P Duffy, Aoife L Gorman, Alex M Liddicoat, Ed C Lavelle, Christoph Hess, Peter J Oefner, David K Finlay, Gavin P Davey, Tracy Robson, Annie M Curtis, Paul J Hertzog, Bryan RG Williams, Claire E McCoy
Mar 05, 2021
Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory...
Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.
Hanne Dubois, Frederic Sorgeloos, Soroush T Sarvestani, Liesbet Martens, Yvan Saeys, Jason M Mackenzie, Mohamed Lamkanfi, Geert van Loo, Ian Goodfellow, Andy Wullaert
Mar 25, 2019
Animals Apoptosis Regulatory Proteins Caliciviridae Infections Cells Cultured Gastrointestinal Tract Inflammasomes Interleukin-1beta Intracellular Signaling Peptides and Proteins MACROPHAGES Mice Mice Inbred C57BL Mice Knockout NLR Family Pyrin Domain-Containing 3 Protein Norovirus Phosphate-Binding Proteins pyroptosis STAT1 Transcription Factor
The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells.
Kimberley A Wiggins, Katerina Pyrillou, Melanie Humphry, Adam S Butterworth, Murray CH Clarke
Oct 13, 2022
Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.
Soni Deshwal, Marleen Forkink, Chou-Hui Hu, Guido Buonincontri, Salvatore Antonucci, Moises Di Sante, Michael P Murphy, Nazareno Paolocci, Daria Mochly-Rosen, Thomas Krieg, Fabio Di Lisa, Nina Kaludercic
May 14, 2018
Monoamine oxidase (MAO) inhibitors ameliorate contractile function in diabetic animals, but the mechanisms remain unknown. Equally elusive is the interplay between the cardiomyocyte alterations induced by hyperglycemia and the...
Animals Cell Degranulation Diabetes mellitus Experimental Endoplasmic reticulum stress Glucose Interleukin-1beta Male Mice Mice Inbred C57BL Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Monoamine Oxidase Monoamine Oxidase Inhibitors Muscle Cells Myocardium RNA Interference RNA Small Interfering Rats Reactive Oxygen Species Ventricular Remodeling
NLRP3 inflammasome pathways in atherosclerosis.
Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns...
Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2)
Thomas P Hellyer, Niall H Anderson, Jennie Parker, Paul Dark, Tina Van Den Broeck, Suveer Singh, Ronan McMullan, Ashley M Agus, Lydia M Emerson, Bronagh Blackwood, Savita Gossain, Tim S Walsh, Gavin D Perkins, Andrew Conway Morris, Daniel F McAuley, A John Simpson
Jul 18, 2018
BACKGROUND: Ventilator-acquired pneumonia (VAP) is a common reason for antimicrobial therapy in the intensive care unit (ICU). Biomarker-based diagnostics could improve antimicrobial stewardship through rapid exclusion of VAP....
Antibiotic stewardship biomarker randomised controlled trial Ventilator-acquired pneumonia Anti-Bacterial Agents Antimicrobial Stewardship Bacteria Biomarkers Bronchoalveolar Lavage Fluid Clinical Protocols Colony Count Microbial Hospital Mortality Humans Interleukin-1beta Interleukin-8 Length of Stay Organ Dysfunction Scores Patient Selection Pneumonia Bacterial Pneumonia Ventilator-Associated Predictive Value of Tests Prospective Studies Research Design Respiration Artificial Time Factors United Kingdom Unnecessary Procedures
TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm.
Marie Vandestienne, Yujiao Zhang, Icia Santos-Zas, Rida Al-Rifai, Jeremie Joffre, Andreas Giraud, Ludivine Laurans, Bruno Esposito, Florence Pinet, Patrick Bruneval, Juliette Raffort, Fabien Lareyre, Jose Vilar, Amir Boufenzer, Lea Guyonnet, Coralie Guerin, Eric Clauser, Jean-Sébastien Silvestre, Sylvie Lang, Laurie Soulat-Dufour, Alain Tedgui, Ziad Mallat, Soraya Taleb, Alexandre Boissonnas, Marc Derive, Giulia Chinetti, Hafid Ait-Oufella
Dec 07, 2020
The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic aneurysm (AAA) remains unknown. Our objective was to explore the...
cell migration/adhesion Inflammation innate immunity Monocytes vascular biology Angiotensin II Animals Aortic Aneurysm Abdominal Cell Movement Gene Deletion Humans Interleukin-1beta Matrix Metalloproteinase 2 Mice Mice Knockout ApoE Monocytes Triggering Receptor Expressed on Myeloid Cells-1 Tumor Necrosis Factor-alpha
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V Arancibia-Cárcamo, Mark Coles, Eamonn Gaffney, Simon PL Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N Sansom, Holm H Uhlig
Jul 01, 2021
OBJECTIVE: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the...
inflammatory bowel disease Interleukins Mucosal immunology Adolescent Adult Aged Aged 80 and over Autocrine Communication Cells Cultured Drug Resistance Female Gene Expression Gene Expression Regulation Gene Regulatory Networks Homeostasis Humans Inflammatory Bowel Diseases Interleukin-10 Interleukin-1alpha Interleukin-1beta Interleukin-23 Subunit p19 Lipopolysaccharides Male Middle Aged Monocytes Paracrine Communication Receptors Interleukin-10 Signal Transduction Transcriptome Tumor Necrosis Factor-alpha Young Adult
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Tomas Castro-Dopico, Thomas W Dennison, John R Ferdinand, Rebeccah J Mathews, Aaron Fleming, Dean Clift, Benjamin J Stewart, Chenzhi Jing, Konstantina Strongili, Larisa I Labzin, Edward JM Monk, Kourosh Saeb-Parsy, Clare E Bryant, Simon Clare, Miles Parkes, Menna R Clatworthy
Feb 18, 2019
Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding...
Fcγ receptors IL-1β IgG inflammatory bowel disease type 17 immunity Animals Antibodies Bacterial Colitis Colitis Ulcerative Dextran Sulfate Gastrointestinal Microbiome Gene Expression Regulation Genotype Humans Immunoglobulin G Inflammation Interleukin-1beta Interleukin-8 Intestinal Mucosa MACROPHAGES Mice Phagocytes RNA Messenger Reactive Oxygen Species Receptors IgG Th17 Cells
Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways.
MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms.
Muna Affara, Benjamin J Dunmore, Deborah A Sanders, Nicola Johnson, Cristin G Print, D Stephen Charnock-Jones
Jun 16, 2011
Cells Cultured Chromatin Immunoprecipitation Female GATA3 Transcription Factor Humans Immunoblotting Inflammation Mediators Interleukin-1beta Interleukin-8 Matrix Metalloproteinase 1 Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Protein Binding Proto-Oncogene Protein c-ets-1 Proto-Oncogene Protein c-ets-2 Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha
Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1β processing.
Sebastian Riedle, Laetitia C Pele, Don E Otter, Rachel Hewitt, Harjinder Singh, Nicole C Roy, Jonathan Powell
Feb 09, 2018
Background. Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma-/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. TiO2...
Cells Cultured MACROPHAGES Animals Mice Inbred C57BL Mice Mutant Strains titanium Acetylmuramyl-Alanyl-Isoglutamine Lipopolysaccharides Tumor Necrosis Factor-alpha Inflammation Mediators Adjuvants Immunologic Food Additives Dose-Response Relationship Drug Genotype Phenotype Mutation Female Interleukin-1beta Nod2 Signaling Adaptor Protein
Salivary Inflammatory Markers in Trichotillomania
BACKGROUND: Immune dysregulation has been hypothesized to be important in the development and pathophysiology of compulsive disorders such as obsessive compulsive disorder (OCD), which has a high comorbid overlap with...
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.
Hui Zhang, Daren Wang, Min Li, Lydie Plecitá-Hlavatá, Angelo D'Alessandro, Jan Tauber, Suzette Riddle, Sushil Kumar, Amanda Flockton, B Alexandre McKeon, Maria G Frid, Julie A Reisz, Paola Caruso, Karim C El Kasmi, Petr Ježek, Nicholas W Morrell, Cheng-Jun Hu, Kurt R Stenmark
Sep 26, 2018
BACKGROUND: An emerging metabolic theory of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We and others have previously demonstrated the...
TEEP-46 Hypoxia metabolism Mitochondria Pyruvate Kinase shikonin splicing factors Alternative Splicing Animals Antagomirs Cattle Cell Proliferation Endothelium Vascular FIBROBLASTS Glycolysis Heterogeneous-Nuclear Ribonucleoproteins Histone Deacetylase Inhibitors Humans Hypertension Pulmonary Interleukin-1beta MACROPHAGES Mice Mice Inbred C57BL MicroRNAs Naphthoquinones Polypyrimidine Tract-Binding Protein Protein Isoforms Pyruvate Kinase RNA Interference
Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors.
Verena Wieser, Timon E Adolph, Barbara Enrich, Athan Kuliopulos, Arthur Kaser, Herbert Tilg, Nicole C Kaneider
Dec 08, 2015
ALCOHOLIC LIVER DISEASE IMMUNE-MEDIATED LIVER DAMAGE INTERLEUKIN 8 Leukocytes Alanine Transaminase Animals Aspartate Aminotransferases Caspase 1 Chemokine CXCL1 Chemotaxis Fatty Liver Alcoholic Female Hep G2 Cells Hepatitis Hepatocytes Humans Interleukin-1beta Lipid Metabolism Lipopeptides Mice Mice Inbred C57BL Neutrophils Peroxidase Receptors Interleukin-8A Receptors Interleukin-8B Signal Transduction Survival Rate Transcription Genetic Triglycerides Tumor Necrosis Factor-alpha Weight Loss
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.
Si Ming Man, Lee J Hopkins, Eileen Nugent, Susan Cox, Ivo M Glück, Panagiotis Tourlomousis, John A Wright, Pietro Cicuta, Tom P Monie, Clare E Bryant
May 08, 2014
ASC Bacteria caspase-1 caspase-8 innate immunity Animals Apoptosis Apoptosis Regulatory Proteins Bone Marrow Cells Calcium-Binding Proteins Carrier Proteins Caspase 1 Caspase 8 Enzyme Activation HEK293 Cells Humans Inflammasomes Inflammation Interleukin-1beta MACROPHAGES Mice Mice Transgenic NLR Family Pyrin Domain-Containing 3 Protein Salmonella typhimurium
Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury.
Lawrence R Shiow, Geraldine Favrais, Lucas Schirmer, Anne-Laure Schang, Sara Cipriani, Christian Andres, Jaclyn N Wright, Hiroko Nobuta, Bobbi Fleiss, Pierre Gressens, David H Rowitch
Dec 12, 2017
Inflammation is a major risk factor for neonatal white matter injury (NWMI), which is associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest of oligodendrocyte progenitor...
Cox2 astrocyte cerebral palsy Neuroinflammation oligodendrocyte prostaglandin white matter Animals Animals Newborn Astrocytes Cells Cultured Cyclooxygenase 2 Dinoprostone Female Fetus Gene Expression Regulation Developmental Glial Fibrillary Acidic Protein Humans Interleukin-1beta L-Lactate Dehydrogenase Male Mice Mice Inbred C57BL Mice Transgenic Oligodendroglia Rats Signal Transduction Spatial Memory white matter
TSLP production by dendritic cells is modulated by IL-1β and components of the endoplasmic reticulum stress response.
dectin-1 ER stress IL-1β TSLP Animals Antigens Fungal Candida albicans Cell Differentiation Cells Cultured Cytokines Dendritic Cells Endoplasmic reticulum stress Glucans Humans Hypersensitivity Interleukin-1beta MAP Kinase Signaling System Mice Mice Inbred C57BL Mice Knockout Monocytes Receptor Cross-Talk Receptors Interleukin-1 Th2 Cells Transcription Factor CHOP Unfolded Protein Response Up-Regulation eIF-2 Kinase Thymic Stromal Lymphopoietin
MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
X Li, S Thome, X Ma, M Amrute-Nayak, A Finigan, L Kitt, L Masters, JR James, Y Shi, G Meng, Z Mallat
Aug 14, 2017
Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection
SJ Webster, S Brode, L Ellis, TJ Fitzmaurice, MJ Elder, NO Gekara, P Tourlomousis, C Bryant, S Clare, R Chee, HJS Gaston, JC Goodall
Aug 15, 2017
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