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Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.
Matthias W Lorenz, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R Srinivasan, Lars Lind, Shuhei Okazaki, Coen DA Stehouwer, Peter Willeit, Joseph F Polak, Helmuth Steinmetz, Dirk Sander, Holger Poppert, Moise Desvarieux, M Arfan Ikram, Stein Harald Johnsen, Daniel Staub, Cesare R Sirtori, Bernhard Iglseder, Oscar Beloqui, Gunnar Engström, Alfonso Friera, Francesco Rozza, Wuxiang Xie, Grace Parraga, Liliana Grigore, Matthieu Plichart, Stefan Blankenberg, Ta-Chen Su, Caroline Schmidt, Tomi-Pekka Tuomainen, Fabrizio Veglia, Henry Völzke, Giel Nijpels, Johann Willeit, Ralph L Sacco, Oscar H Franco, Heiko Uthoff, Bo Hedblad, Carmen Suarez, Raffaele Izzo, Dong Zhao, Thapat Wannarong, Alberico Catapano, Pierre Ducimetiere, Christine Espinola-Klein, Kuo-Liong Chien, Jackie F Price, Göran Bergström, Jussi Kauhanen, Elena Tremoli, Marcus Dörr, Gerald Berenson, Kazuo Kitagawa, Jacqueline M Dekker, Stefan Kiechl, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Ellisiv B Mathiesen, Samuela Castelnuovo, Manuel F Landecho, Maria Rosvall, Rafael Gabriel, Nicola de Luca, Jing Liu, Damiano Baldassarre, Maryam Kavousi, Eric de Groot, Michiel L Bots, David N Yanez, Simon G Thompson, PROG-IMT Study Group
Jun 19, 2018
AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular...
Systemic Markers of Injury and Injury Response Are Not Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Sep 15, 2020
The role of extra-cranial injury burden and systemic injury response on cerebrovascular response in traumatic brain injury (TBI) is poorly documented. This study preliminarily assesses the association between admission features...
TBI autoregulation cerebrovascular reactivity extra-cranial injury injury burden Adult Biomarkers Biomedical Research Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Europe Female Humans Intersectoral Collaboration Male Middle Aged Patient Admission Prospective Studies Treatment Outcome
A New Approach to Evidence Synthesis in Traumatic Brain Injury
Anneliese Synnot, Russell L Gruen, David Menon, Ewout W Steyerberg, Andras Buki, Wilco C Peul, Julian H Elliott, Andrew Maas
Jun 21, 2018
Living systematic reviews (LSRs) are online summaries of health care research that are updated as new research becomes available. This new development in evidence synthesis is being trialled as part of the Collaborative European...
Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury
Frederick A Zeiler, Erta Beqiri, Manuel Cabeleira, Peter J Hutchinson, Nino Stocchetti, David K Menon, Marek Czosnyka, Peter Smielewski, Ari Ercole, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Mar 31, 2020
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO2) are associated with outcome in traumatic brain injury (TBI). This study explores the relationship between PRx and PbtO2 in adult moderate/severe TBI. Using the...
ICP autoregulation brain tissue oxygen physiological burden Adult Aged Biomedical Research Brain Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Cost of Illness Europe Female Glasgow Outcome Scale Humans Intersectoral Collaboration Male Middle Aged Oxygen Consumption Prospective Studies Treatment Outcome
Solve-RD
Birte Zurek, Kornelia Ellwanger, Lisenka ELM Vissers, Rebecca Schüle, Matthis Synofzik, Ana Töpf, Richarda M de Voer, Steven Laurie, Leslie Matalonga, Christian Gilissen, Stephan Ossowski, Peter AC 't Hoen, Antonio Vitobello, Julia M Schulze-Hentrich, Olaf Riess, Han G Brunner, Anthony J Brookes, Ana Rath, Gisèle Bonne, Gulcin Gumus, Alain Verloes, Nicoline Hoogerbrugge, Teresinha Evangelista, Tina Harmuth, Morris Swertz, Dylan Spalding, Alexander Hoischen, Sergi Beltran, Holm Graessner, Solve-RD Consortium
Sep 15, 2021
For the first time in Europe hundreds of rare disease (RD) experts team up to actively share and jointly analyse existing patient's data. Solve-RD is a Horizon 2020-supported EU flagship project bringing together >300...
Does characterising patterns of multimorbidity in stroke matter for developing collaborative care approaches in primary care?
Effectiveness of a quality improvement collaborative in reducing time to surgery for patients requiring emergency cholecystectomy.
JR Bamber, TJ Stephens, DA Cromwell, E Duncan, GP Martin, NF Quiney, JF Abercrombie, IJ Beckingham, Cholecystectomy Quality Improvement Collaborative
Oct 11, 2019
BACKGROUND: Acute gallstone disease is a high-volume emergency general surgery presentation with wide variations in the quality of care provided across the UK. This controlled cohort evaluation assessed whether participation in...
Learning hand in hand
Kelly Lynn Mulvey, Luke McGuire, Adam J Hoffman, Adam Hartstone-Rose, Mark Winterbottom, Frances Balkwill, Grace E Fields, Karen Burns, Marc Drews, Melissa Chatton, Natalie Eaves, Fidelia Law, Angelina Joy, Adam Rutland
Apr 01, 2021
Developmental science research often involves research questions developed by academic teams, which are tested within community or educational settings. In this piece, we outline the importance of research-practice partnerships...
Proficiency Testing of Virus Diagnostics Based on Bioinformatics Analysis of Simulated In Silico High-Throughput Sequencing Data Sets.
Annika Brinkmann, Andreas Andrusch, Ariane Belka, Claudia Wylezich, Dirk Höper, Anne Pohlmann, Thomas Nordahl Petersen, Pierrick Lucas, Yannick Blanchard, Anna Papa, Angeliki Melidou, Bas B Oude Munnink, Jelle Matthijnssens, Ward Deboutte, Richard J Ellis, Florian Hansmann, Wolfgang Baumgärtner, Erhard van der Vries, Albert Osterhaus, Cesare Camma, Iolanda Mangone, Alessio Lorusso, Maurilia Marcacci, Alexandra Nunes, Miguel Pinto, Vítor Borges, Annelies Kroneman, Dennis Schmitz, Victor Max Corman, Christian Drosten, Terry C Jones, Rene S Hendriksen, Frank M Aarestrup, Marion Koopmans, Martin Beer, Andreas Nitsche
Jan 09, 2020
Quality management and independent assessment of high-throughput sequencing-based virus diagnostics have not yet been established as a mandatory approach for ensuring comparable results. The sensitivity and specificity of viral...
external quality assessment high-throughput sequencing next-generation sequencing proficiency testing virus diagnostics Computational Biology Computer Simulation Data analysis Europe Genome Viral High-Throughput Nucleotide Sequencing Humans Intersectoral Collaboration Laboratory Proficiency Testing Reproducibility of Results Sequence Analysis DNA viruses
A new era for collaboration?
Jonathan C Packham, Sonya Abraham, Bruce Kirkham, Philip Helliwell, Stefan Siebert, Ellie Korendowych, Oliver FitzGerald, Andrew Parkinson, Mel Brookes, Laura Coates, Neil McHugh
May 01, 2018
Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients
François Mathieu, Frederick A Zeiler, Ari Ercole, Miguel Monteiro, Konstantinos Kamnitsas, Ben Glocker, Daniel P Whitehouse, Tilak Das, Peter Smielewski, Marek Czosnyka, Peter J Hutchinson, Virginia FJ Newcombe, David K Menon, CENTER-TBI High Resolution Sub-Study Participants and Investigators
May 05, 2020
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may...
cerebral autoregulation Intracranial hemorrhage Traumatic brain injury Adult Brain Injuries Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Disease Progression Europe Female Humans Intensive Care Units Intersectoral Collaboration Male Middle Aged Tomography X-Ray Computed Treatment Outcome
A new era for collaboration?
Jonathan C Packham, Sonya Abraham, Bruce Kirkham, Philip Helliwell, Stefan Siebert, Ellie Korendowych, Oliver FitzGerald, Andrew Parkinson, Mel Brookes, Laura Coates, Neil McHugh
May 01, 2018
Toward a New Multi-Dimensional Classification of Traumatic Brain Injury
Benjamin Y Gravesteijn, Charlie A Sewalt, Ari Ercole, Cecilia Akerlund, David Nelson, Andrew IR Maas, David Menon, Hester F Lingsma, Ewout W Steyerberg, Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Collaborators
Oct 28, 2019
Traumatic brain injury (TBI) is currently classified as mild, moderate, or severe TBI by trichotomizing the Glasgow Coma Scale (GCS). We aimed to explore directions for a more refined multidimensional classification system. For...