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Animals Basic Helix-Loop-Helix Transcription Factors Cell Lineage Female Gene Expression Profiling Hippocampus Homeodomain Proteins Intravital Microscopy Male Metallothionein 3 Mice Mice Inbred C57BL Mice Transgenic Microscopy Fluorescence Multiphoton Nerve Regeneration Nerve Tissue Proteins Neural Stem Cells Single-Cell Analysis Zinc Finger Protein GLI1

Animals Axon guidance Axons Carbocyanines Corpus Striatum Dopaminergic Neurons Embryo Mammalian Female Fluorescent Dyes Intracellular Signaling Peptides and Proteins Intravital Microscopy Mice Knockout Microfluidic Analytical Techniques Microinjections Microscopy Confocal Nerve Net Nerve Tissue Proteins Tissue Culture Techniques

The anaphase-promoting complex/cyclosome (APC/C) orchestrates cell cycle progression by controlling the temporal degradation of specific cell cycle regulators. Although cyclin A2 and cyclin B1 are both targeted for degradation...

Amino Acid Motifs Anaphase-Promoting Complex-Cyclosome CDC2-CDC28 Kinases Cdc20 Proteins Cell Cycle Proteins Cryoelectron Microscopy Cyclin A2 HEK293 Cells Humans Intravital Microscopy M Phase Cell Cycle Checkpoints Models Molecular Protein Binding Proteolysis Spindle Apparatus Substrate Specificity Ubiquitination

Eph/ephrin GBM cancer biology Cancer Stem cells Cell Biology human MOUSE perivascular invasion Animals Cell Movement Cell Proliferation Ephrin-B2 Glioblastoma Heterografts Humans Intravital Microscopy Mice Neoplastic Stem Cells

The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated...

FLIM-FRET actin Biosensors Breast Cancer Cell Biology development immunology intravital imaging pancreatic cancer small GTPase RhoA Animals Antineoplastic Agents Biosensing Techniques Bone and Bones Cell Movement Dasatinib Erlotinib Hydrochloride Female Fluorescence Resonance Energy Transfer Gene Expression Regulation Intestine Small Intravital Microscopy Mammary Glands Animal Mammary Neoplasms Experimental Mechanotransduction Cellular Mice Mice Transgenic Neutrophils Osteocytes Pancreatic Neoplasms Time-Lapse Imaging rho GTP-Binding Proteins rhoA GTP-Binding Protein

The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped with exquisite spatial resolution along the 1D genome...

Genes Reporter Green Fluorescent Proteins HeLa Cells Humans Intravital Microscopy Microscopy Fluorescence Phosphorylation Promoter Regions Genetic RNA Polymerase II RNA Messenger Serine single molecule imaging Spatio-Temporal Analysis Time-Lapse Imaging Transcription Genetic

Anti-Bacterial Agents Bacterial Outer Membrane Proteins Carrier Proteins Cryoelectron Microscopy Drug Resistance Multiple Bacterial Electron Microscope Tomography Escherichia coli Escherichia coli Proteins Intravital Microscopy Lipoproteins Membrane Transport Proteins Multidrug Resistance-Associated Proteins Peptidoglycan Periplasm Protein Binding Protein Structure Quaternary

During gastrulation of the zebrafish embryo, the cap of blastoderm cells organizes into the axial body plan of the embryo with left-right symmetry and head-tail, dorsal-ventral polarities. Our labs have been interested in the...

Animals Benzeneacetamides Body Patterning Cell Movement Embryo Nonmammalian Gastrulation Intravital Microscopy Pyridines Wnt Proteins Zebrafish Zebrafish Proteins

Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological motion caused by peristalsis, respiration and the heartbeat can present a significant...

FLIM FRET Cell Biology Computational Biology human Intravital Microscopy motion correction MOUSE multiphoton Systems Biology Algorithms Animals Biosensing Techniques Cell Adhesion Computer Simulation Fluorescence Resonance Energy Transfer Guanosine Triphosphate Humans Imaging Three-Dimensional Intestines Intravital Microscopy Mice Microscopy Fluorescence Models Biological Motion Neoplasm Metastasis Neuropeptides Pancreatic Neoplasms Skin Software rac1 GTP-Binding Protein src-Family Kinases

Trypanosomes are important disease agents of humans, livestock and cold-blooded species, including fish. The cellular morphology of trypanosomes is central to their motility, adaptation to the host's environments and...

Trypanosoma carassii host-pathogen interaction infectious disease microbiology swimming behavior Zebrafish Animals Blood Cell Adhesion Disease Models Animal Intravital Microscopy Locomotion Spatio-Temporal Analysis Trypanosoma Trypanosomiasis Zebrafish

The bone marrow is a central organ of the immune system, which hosts complex interactions of bone and immune compartments critical for hematopoiesis, immunological memory, and bone regeneration. Although these processes take...

Animals Bone Marrow Bone Marrow Cells Femur Hematopoiesis Homeostasis Intravital Microscopy Mice Inbred C57BL Mice Transgenic Microscopy Fluorescence Multiphoton Stem Cell Niche

The midbody is an organelle assembled at the intercellular bridge between the two daughter cells at the end of mitosis. It controls the final separation of the daughter cells and has been involved in cell fate, polarity, tissue...

Aurora Kinase B Binding Sites Cytokinesis HeLa Cells Humans Intravital Microscopy Microtubule-Associated Proteins Microtubules Mitosis Mutagenesis Site-Directed Myosin-Light-Chain Phosphatase Phosphorylation Protein Interaction Maps Protein Phosphatase 1 RNA Small Interfering Spindle Apparatus Time-Lapse Imaging

OBJECTIVE AND BACKGROUND: Activation of sterile inflammation after hepatic ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with mitochondrial oxidative stress and cell death during early...

antioxidants Damage-associated molecular patterns Intravital Microscopy Liver resection Mitochondrial DNA Sterile inflammation Aged Alarmins antioxidants Cytokines DNA Mitochondrial Female HMGB1 Protein Humans Liver Male Middle Aged Mitochondria Organophosphorus Compounds Oxidative Stress Reperfusion Injury Ubiquinone

Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s are also...

innate lymphoid cell intravital imaging lymph node mucosa type 2 inflammation Animals Genes Reporter Interleukin-13 Intestinal Diseases Parasitic Intestinal Mucosa Intestine Small Intravital Microscopy Lymphocyte Count Lymphocyte Subsets Mice Nippostrongylus Organ Specificity Schistosomiasis mansoni Specific Pathogen-Free Organisms Strongylida Infections Th2 Cells