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Results: 33
BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding.
Hypoglycemia or glucoprivation triggers protective hormonal counterregulatory and feeding responses to aid the restoration of normoglycemia. Increasing evidence suggests pertinent roles for the brain in sensing glucoprivation...
Brain glucose sensing, glucokinase and neural control of metabolism and islet function.
glucokinase glucose sensing glucose-stimulated insulin secretion hypoglycaemia Hypothalamus Insulin Animals Brain Diabetes mellitus Energy Metabolism Feedback Physiological Glucokinase Glucose Humans Hypoglycemia Insulin Insulin Secretion Islets of Langerhans Models Neurological Nerve Tissue Proteins Neuroglia Neurons obesity Organ Specificity
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
Alice E Adriaenssens, Berit Svendsen, Brian YH Lam, Giles SH Yeo, Jens J Holst, Frank Reimann, Fiona M Gribble
Jun 29, 2016
Alpha cells Beta cells Delta cells Ghrelin Glucagon Insulin RNA sequencing Somatostatin Animals Calcium Ghrelin Glucagon Glucagon-Secreting Cells Insulin Insulin-Secreting Cells Islets of Langerhans Male Mice Mice Inbred C57BL Mice Transgenic Reverse Transcriptase Polymerase Chain Reaction Somatostatin-Secreting Cells Transcriptome
Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses.
Short-term hyperglycemia suppresses superior cervical ganglia neurotransmission. If this ganglionic dysfunction also occurs in the islet sympathetic pathway, sympathetically mediated glucagon responses could be impaired. Our...
WLDS celiac ganglia fos Glucagon nicotinic acetylcholine receptors Norepinephrine sympathetic nervous system Animals Diabetes mellitus Type 1 Down-Regulation Electric Stimulation Ganglia Sympathetic Ganglionic Stimulants Glucagon Hyperglycemia Islets of Langerhans Male Mutant Proteins Nerve Tissue Proteins Neurons Nicotinic Agonists Norepinephrine Proto-Oncogene Proteins c-fos Rats Sprague-Dawley Rats Transgenic Rats Wistar Receptors Nicotinic Synaptic Transmission Wallerian degeneration
Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes.
Robert A Benson, Fabien Garcon, Asha Recino, John R Ferdinand, Menna R Clatworthy, Herman Waldmann, James M Brewer, Klaus Okkenhaug, Anne Cooke, Paul Garside, Maja Wållberg
Sep 05, 2018
T cell anti-CD3 Autoimmunity Imaging Immunotherapy islets multiphoton type 1 diabetes Animals Autoimmunity Diabetes mellitus Type 1 Disease Models Animal Ear Auricle Islets of Langerhans Islets of Langerhans Transplantation Mice Mice Inbred C57BL Mice Inbred NOD Mice SCID Mice Transgenic Microscopy Fluorescence Multiphoton Muromonab-CD3 T-Lymphocytes Transplantation Isogeneic
Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression.
Ahmed I Mahmoud, Francisco X Galdos, Katherine A Dinan, Mark P Jedrychowski, Jeffrey C Davis, Ana Vujic, Inbal Rachmin, Christian Shigley, James R Pancoast, Samuel Lee, Jennifer Hollister-Lock, Catherine M MacGillivray, Steven P Gygi, Douglas A Melton, Gordon C Weir, Richard T Lee
Oct 16, 2020
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At...
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.
Michelle Goldsworthy, Nathan L Absalom, David Schröter, Helen C Matthews, Debora Bogani, Lee Moir, Anna Long, Christopher Church, Alison Hugill, Quentin M Anstee, Rob Goldin, Mark Thursz, Florian Hollfelder, Roger D Cox
Jan 22, 2021
We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type...
Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice.
Ryan A Lafferty, Neil Tanday, R Charlotte Moffett, Frank Reimann, Fiona M Gribble, Peter R Flatt, Nigel Irwin
Jan 29, 2021
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study...
Diabetes Peptide YY sea lamprey PYY streptozotocin transdifferentiation Animals Bacterial Proteins Blood Glucose Cell Differentiation Diabetes mellitus Experimental Glucagon Glucagon-Secreting Cells Insulin Insulin-Secreting Cells Islets of Langerhans Luminescent Proteins Mice Mice Inbred C57BL Neuropeptide Y Peptides Petromyzon Streptozocin Transgenes
Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice.
Dipak Sarnobat, R Charlotte Moffett, Victor A Gault, Neil Tanday, Frank Reimann, Fiona M Gribble, Peter R Flatt, Nigel Irwin
Nov 18, 2019
Alpha-cell Glu (CreERT2) ROSA26-eYFP mice Glucose-dependent insulinotropic polypeptide (GIP) Oxytomodulin (Oxm) transdifferentiation Xenin Animals Bacterial Proteins Cell Transdifferentiation Diabetes mellitus Experimental Diabetes mellitus Type 1 Gastric Inhibitory Polypeptide Gastrointestinal Agents Glucagon-Secreting Cells Islets of Langerhans Luminescent Proteins Mice Mice Inbred C57BL Mice Transgenic Neurotensin Oxyntomodulin
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Olga Rudenko, Jin Shang, Alexander Munk, Jeppe P Ekberg, Natalia Petersen, Maja S Engelstoft, Kristoffer L Egerod, Siv A Hjorth, Margaret Wu, Yue Feng, Yun-Ping Zhou, Jacek Mokrosinski, Peter Thams, Frank Reimann, Fiona Gribble, Jens F Rehfeld, Jens J Holst, Jonas T Treebak, Andrew D Howard, Thue W Schwartz
Apr 05, 2019
OBJECTIVES: GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear. METHODS AND...
amino acid sensing G-protein-coupled receptor GPR142 Glucose homeostasis Trp Amino Acids Aromatic Animals Blood Glucose Glucagon Glucagon-Like Peptide 1 Glucagon-Like Peptide-1 Receptor Glucagon-Secreting Cells Glucose Insulin Insulin-Secreting Cells Islets of Langerhans Male Mice Mice Inbred C57BL Mice Knockout Mice Obese Rats Rats Zucker Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone Receptors Glucagon Tryptophan
Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model.
Paul Richards, Helen E Parker, Alice E Adriaenssens, Joshua M Hodgson, Simon C Cork, Stefan Trapp, Fiona M Gribble, Frank Reimann
Jul 09, 2014
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao-Khanh Lai, Davide Brusa, Birgit Stierstorfer, Holger Klein, Bilal Singh, Lucie Ruiz, Michael Pieper, Michael Mark, Pedro L Herrera, Fiona M Gribble, Frank Reimann, Anne Wojtusciszyn, Christophe Broca, Nano Rita, Lorenzo Piemonti, Patrick Gilon
Nov 13, 2020
OBJECTIVE: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i), or gliflozins, are anti-diabetic drugs that lower glycemia by promoting glucosuria, but they also stimulate endogenous glucose and ketone body production....
Diabetes Gliflozins Glucagon Insulin SGLT2 inhibitor Animals Benzhydryl Compounds Blood Glucose Glucagon Glucagon-Like Peptide 1 Glucagon-Secreting Cells Glucose Glucosides Humans Insulin Insulin Secretion Insulin-Secreting Cells Islets of Langerhans Mice Pancreas Rats Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Anastasia Georgiadi, Valeria Lopez-Salazar, Rabih El- Merahbi, Rhoda Anane Karikari, Xiaochuan Ma, André Mourão, Katarina Klepac, Lea Bühler, Ana Jimena Alfaro, Isabell Kaczmarek, Adam Linford, Madeleen Bosma, Olga Shilkova, Olli Ritvos, Nobuhiro Nakamura, Shigehisa Hirose, Maximilian Lassi, Raffaele Teperino, Juliano Machado, Marcel Scheideler, Arne Dietrich, Arie Geerlof, Annette Feuchtinger, Andreas Blutke, Katrin Fischer, Timo Dirk Müller, Katharina Kessler, Torsten Schöneberg, Doreen Thor, Silke Hornemann, Michael Kruse, Peter Nawroth, Olga Pivovarova-Ramich, Andreas Friedrich Hermann Pfeiffer, Michael Sattler, Matthias Blüher, Stephan Herzig
Jun 21, 2021
The proper functional interaction between different tissues represents a key component in systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is a hallmark of severe metabolic dysfunction in...
3T3-L1 Cells Adipocytes Adipose Tissue White Adolescent Adult Aged Animals CHO Cells Cohort Studies Cricetulus Cross-Sectional Studies Diabetes mellitus Type 2 Diet High-Fat Disease Models Animal Female Gene Knockdown Techniques Glucose HEK293 Cells Hep G2 Cells Humans Insulin Insulin Resistance Islets of Langerhans Liver Male Membrane Proteins Mice Mice Knockout Middle Aged NIH 3T3 Cells Prediabetic State Primary Cell Culture Proteins Receptors G-Protein-Coupled Recombinant Fusion Proteins Young Adult
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, Michael E Reschen, Anubha Mahajan, Adam Locke, N William Rayner, Neil Robertson, Robert A Scott, Inga Prokopenko, Laura J Scott, Todd Green, Thomas Sparso, Dorothee Thuillier, Loic Yengo, Harald Grallert, Simone Wahl, Mattias Frånberg, Rona J Strawbridge, Hans Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Lu Qi, Lennart C Karssen, Elisabeth M van Leeuwen, Sara M Willems, Man Li, Han Chen, Christian Fuchsberger, Phoenix Kwan, Clement Ma, Michael Linderman, Yingchang Lu, Soren K Thomsen, Jana K Rundle, Nicola L Beer, Martijn van de Bunt, Anil Chalisey, Hyun Min Kang, Benjamin F Voight, Gonçalo R Abecasis, Peter Almgren, Damiano Baldassarre, Beverley Balkau, Rafn Benediktsson, Matthias Blüher, Heiner Boeing, Lori L Bonnycastle, Erwin P Bottinger, Noël P Burtt, Jason Carey, Guillaume Charpentier, Peter S Chines, Marilyn C Cornelis, David J Couper, Andrew T Crenshaw, Rob M van Dam, Alex SF Doney, Mozhgan Dorkhan, Sarah Edkins, Johan G Eriksson, Tonu Esko, Elodie Eury, João Fadista, Jason Flannick, Pierre Fontanillas, Caroline Fox, Paul W Franks, Karl Gertow, Christian Gieger, Bruna Gigante, Omri Gottesman, George B Grant, Niels Grarup, Christopher J Groves, Maija Hassinen, Christian T Have, Christian Herder, Oddgeir L Holmen, Astradur B Hreidarsson, Steve E Humphries, David J Hunter, Anne U Jackson, Anna Jonsson, Marit E Jørgensen, Torben Jørgensen, Wen-Hong L Kao, Nicola D Kerrison, Leena Kinnunen, Norman Klopp, Augustine Kong, Peter Kovacs, Peter Kraft, Jasmina Kravic, Cordelia Langford, Karin Leander, Liming Liang, Peter Lichtner, Cecilia M Lindgren, Eero Lindholm, Allan Linneberg, Ching-Ti Liu, Stéphane Lobbens, Jian'an Luan, Valeriya Lyssenko, Satu Männistö, Olga McLeod, Julia Meyer, Evelin Mihailov, Ghazala Mirza, Thomas W Mühleisen, Martina Müller-Nurasyid, Carmen Navarro, Markus M Nöthen, Nikolay N Oskolkov, Katharine R Owen, Domenico Palli, Sonali Pechlivanis, Leena Peltonen, John RB Perry, Carl GP Platou, Michael Roden, Douglas Ruderfer, Denis Rybin, Yvonne T van der Schouw, Bengt Sennblad, Gunnar Sigurðsson, Alena Stančáková, Gerald Steinbach, Petter Storm, Konstantin Strauch, Heather M Stringham, Qi Sun, Barbara Thorand, Emmi Tikkanen, Anke Tonjes, Joseph Trakalo, Elena Tremoli, Tiinamaija Tuomi, Roman Wennauer, Steven Wiltshire, Andrew R Wood, Eleftheria Zeggini, Ian Dunham, Ewan Birney, Lorenzo Pasquali, Jorge Ferrer, Ruth JF Loos, Josée Dupuis, Jose C Florez, Eric Boerwinkle, James S Pankow, Cornelia van Duijn, Eric Sijbrands, James B Meigs, Frank B Hu, Unnur Thorsteinsdottir, Kari Stefansson, Timo A Lakka, Rainer Rauramaa, Michael Stumvoll, Nancy L Pedersen, Lars Lind, Sirkka M Keinanen-Kiukaanniemi, Eeva Korpi-Hyövälti, Timo E Saaristo, Juha Saltevo, Johanna Kuusisto, Markku Laakso, Andres Metspalu, Raimund Erbel, Karl-Heinz Jöcke, Susanne Moebus, Samuli Ripatti, Veikko Salomaa, Erik Ingelsson, Bernhard O Boehm, Richard N Bergman, Francis S Collins, Karen L Mohlke, Heikki Koistinen, Jaakko Tuomilehto, Kristian Hveem, Inger Njølstad, Panagiotis Deloukas, Peter J Donnelly, Timothy M Frayling, Andrew T Hattersley, Ulf de Faire, Anders Hamsten, Thomas Illig, Annette Peters, Stephane Cauchi, Rob Sladek, Philippe Froguel, Torben Hansen, Oluf Pedersen, Andrew D Morris, Collin NA Palmer, Sekar Kathiresan, Olle Melander, Peter M Nilsson, Leif C Groop, Inês Barroso, Claudia Langenberg, Nicholas J Wareham, Christopher A O'Callaghan, Anna L Gloyn, David Altshuler, Michael Boehnke, Tanya M Teslovich, Mark I McCarthy, Andrew P Morris, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Jan 23, 2018
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near...
Binding Sites Case-Control Studies Chromatin Immunoprecipitation Chromosome Mapping Diabetes mellitus Type 2 Gene Expression Regulation Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genomics Hepatocyte Nuclear Factor 3-beta Humans Islets of Langerhans Liver Molecular Sequence Annotation Polymorphism Single Nucleotide Receptor Melatonin MT2
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
Mariano F Zacarías-Fluck, Toni Jauset, Sandra Martínez-Martín, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Daniel Massó-Vallés, Erika Serrano Del Pozo, Génesis Martín-Fernández, Íñigo González-Larreategui, Sergio López-Estévez, Lamorna Brown-Swigart, Marie-Eve Beaulieu, Jonathan R Whitfield, Babita Madan, David M Virshup, Gerard I Evan, Laura Soucek
May 17, 2021
The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as...
Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets.
Nikola Dolezalova, Anja Gruszczyk, Kerry Barkan, John A Gamble, Sam Galvin, Till Moreth, Kevin O'Holleran, Krishnaa T Mahbubani, Jackie A Higgins, Fiona M Gribble, Frank Reimann, Jakub Surmacki, Simon Andrews, John J Casey, Francesco Pampaloni, Michael P Murphy, Graham Ladds, Nigel Kh Slater, Kourosh Saeb-Parsy
May 24, 2021
Cryopreservation offers the potential to increase the availability of pancreatic islets for treatment of diabetic patients. However, current protocols, which use dimethyl sulfoxide (DMSO), lead to poor cryosurvival of islets. We...
Metabolomics and Lipidomics Study of Mouse Models of Type 1 Diabetes Highlights Divergent Metabolism in Purine and Tryptophan Metabolism Prior to Disease Onset.
Steven A Murfitt, Paola Zaccone, Xinzhu Wang, Animesh Acharjee, Yvonne Sawyer, Albert Koulman, Lee D Roberts, Anne Cooke, Julian Leether Griffin
Sep 10, 2018
With the increase in incidence of type 1 diabetes (T1DM), there is an urgent need to understand the early molecular and metabolic alterations that accompany the autoimmune disease. This is not least because in murine models...
NOD-severe combined immunodeficiency (SCID) mouse kynurenic acid Mass Spectrometry nonobese diabetic (NOD) mouse xanthinine Animals Autoimmunity Chromatography Liquid Diabetes mellitus Type 1 Discriminant Analysis Disease Models Animal Female Gas Chromatography-Mass Spectrometry Gene Expression Histocompatibility Antigens Class II Islets of Langerhans Kynurenic Acid Lipid Metabolism Lysophospholipids Metabolomics Mice Mice Inbred NOD Mice SCID Mice Transgenic Prediabetic State principal component analysis Protein Multimerization Purines Tryptophan
Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.
Ionel Sandovici, Constanze M Hammerle, Wendy N Cooper, Noel H Smith, Jane L Tarry-Adkins, Benjamin J Dunmore, Julien Bauer, Simon R Andrews, Giles SH Yeo, Susan E Ozanne, Miguel Constância
Sep 12, 2016
Ageing DNA Methylation epigenetics Inflammageing Pancreatic islets Type 2 diabetes aging Animals Chemokine CXCL9 Collagen Type III DNA Methylation Diabetes mellitus Type 2 Epigenesis Genetic Inflammation Islets of Langerhans KCNQ1 Potassium Channel Male Phosphoric Diester Hydrolases Pyrophosphatases Rats Sulfonylurea Receptors Tetraspanins
The Human and Mouse Islet Peptidome
Sam G Galvin, Richard G Kay, Rachel Foreman, Pierre Larraufie, Claire L Meek, Emma Biggs, Peter Ravn, Lutz Jermutus, Frank Reimann, Fiona M Gribble
Aug 12, 2021
Improving glycemic control in critically ill patients
J Geoffrey Chase, Thomas Desaive, Julien Bohe, Miriam Cnop, Christophe De Block, Jan Gunst, Roman Hovorka, Pierre Kalfon, James Krinsley, Eric Renard, Jean-Charles Preiser
Sep 10, 2018
There is considerable physiological and clinical evidence of harm and increased risk of death associated with dysglycemia in critical care. However, glycemic control (GC) currently leads to increased hypoglycemia, independently...
Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice.
Lisa M Nicholas, Mototsugu Nagao, Laura C Kusinski, Denise S Fernandez-Twinn, Lena Eliasson, Susan E Ozanne
Oct 31, 2019
Beta cell islets Maternal obesity Type 2 diabetes Adenosine Triphosphate Animals Apoptosis Blotting Western DNA Mitochondrial Diabetes mellitus Type 2 Female Fluorescent Antibody Technique Islets of Langerhans Male Mice Mice Inbred C57BL Microscopy Electron Transmission obesity Maternal Oxygen Consumption Pregnancy Reverse Transcriptase Polymerase Chain Reaction Sex Characteristics
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Julia Ast, Anastasia Arvaniti, Nicholas HF Fine, Daniela Nasteska, Fiona B Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J Jones, Maria A Lucey, Shugo Sasaki, Daniel I Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D'Agostino, Frank Reimann, Francis C Lynn, Christopher A Reissaus, Amelia K Linnemann, Elisa D'Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J Hodson
Jan 29, 2020
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the use of probes that...
Amino Acid Sequence Animals Brain Cell Line Fluorescent Dyes Glucagon-Like Peptide-1 Receptor HEK293 Cells Human Embryonic Stem Cells Humans Islets of Langerhans Mice Mice Knockout Microscopy Fluorescence Multiphoton Models Molecular Molecular Structure Peptide Fragments Signal Transduction Tissue Distribution
Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression.
Louis-Pascal Xhonneux, Oliver Knight, Åke Lernmark, Ezio Bonifacio, William A Hagopian, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Hemang Parikh, Kenneth GC Smith, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Eoin F McKinney
Apr 07, 2021
Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
Henry J Taylor, Yu-Han Hung, Narisu Narisu, Michael R Erdos, Matthew Kanke, Tingfen Yan, Caleb M Grenko, Amy J Swift, Lori L Bonnycastle, Praveen Sethupathy, Francis S Collins, D Leland Taylor
Mar 13, 2023
Genetic studies have identified ≥240 loci associated with the risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mechanisms. Recent studies investigating mRNA...
Deciphering c-MYC-regulated genes in two distinct tissues.
Samuel C Robson, Lesley Ward, Helen Brown, Heather Turner, Ewan Hunter, Stella Pelengaris, Michael Khan
Feb 23, 2012
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