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Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.
Yun Song, Lisbeth Dagil, Louise Fairall, Naomi Robertson, Mingxuan Wu, TJ Ragan, Christos G Savva, Almutasem Saleh, Nobuhiro Morone, Micha BA Kunze, Andrew G Jamieson, Philip A Cole, D Flemming Hansen, John WR Schwabe
Feb 28, 2020
The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase...
CoREST complex HDAC1 KDM1A LSD1 RCOR1 Histone deacetylase lysine demethylase nucleosome Acetylation Amino Acid Sequence Animals Co-Repressor Proteins Cryoelectron Microscopy Demethylation HEK293 Cells Histone Deacetylase 1 Histone Demethylases Humans Kinetics Models Molecular Nerve Tissue Proteins Nucleosomes Xenopus