Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
Lucas Schirmer,
Wiebke Möbius,
Chao Zhao,
Andrés Cruz-Herranz,
Lucile Ben Haim,
Christian Cordano,
Lawrence R Shiow,
Kevin W Kelley,
Boguslawa Sadowski,
Garrett Timmons,
Anne-Katrin Pröbstel,
Jackie N Wright,
Jung Hyung Sin,
Michael Devereux,
Daniel E Morrison,
Sandra M Chang,
Khalida Sabeur,
Ari J Green,
Klaus-Armin Nave,
Robin Jm Franklin,
David H Rowitch
Nov 19, 2018
Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes...