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Results: 55
Detection of translational noncrystallographic symmetry in Patterson functions.
Iracema Caballero, Massimo D Sammito, Pavel V Afonine, Isabel Usón, Randy J Read, Airlie J McCoy
Jan 11, 2021
Detection of translational noncrystallographic symmetry (TNCS) can be critical for success in crystallographic phasing, particularly when molecular-replacement models are poor or anomalous phasing information is weak. If the...
The versatility of multi-state models for the analysis of longitudinal data with unobservable features.
Multi-state models provide a convenient statistical framework for a wide variety of medical applications characterized by multiple events and longitudinal data. We illustrate this through four examples. The potential value of...
Likelihood-based signal and noise analysis for docking of models into cryo-EM maps.
Fast, reliable docking of models into cryo-EM maps requires understanding of the errors in the maps and the models. Likelihood-based approaches to errors have proven to be powerful and adaptable in experimental structural...
A review of instrumental variable estimators for Mendelian randomization.
instrumental variable Mendelian randomization causal inference comparison of methods finite-sample bias weak instruments Bayes Theorem Case-Control Studies Causality Confidence Intervals genetic variation Humans Least-Squares Analysis Likelihood Functions Mendelian Randomization Analysis Models Statistical Risk Factors
Implementing informative priors for heterogeneity in meta-analysis using meta-regression and pseudo data.
Kirsty M Rhodes, Rebecca M Turner, Ian R White, Dan Jackson, David J Spiegelhalter, Julian PT Higgins
Jun 18, 2018
Many meta-analyses combine results from only a small number of studies, a situation in which the between-study variance is imprecisely estimated when standard methods are applied. Bayesian meta-analysis allows incorporation of...
A Review of Risk Matrices Used in Acute Hospitals in England.
In healthcare, patient safety has received substantial attention and, in turn, a number of approaches to managing safety have been adopted from other high-risk industries. One of these has been risk assessment, predominantly...
The many weak instruments problem and Mendelian randomization.
Neil M Davies, Stephanie von Hinke Kessler Scholder, Helmut Farbmacher, Stephen Burgess, Frank Windmeijer, George Davey Smith
Oct 22, 2014
ALSPAC Mendelian randomization allele scores continuously updating estimator height many weak instruments Adolescent Alleles Bias Body Height Causality Cohort Studies Computer Simulation England Female genetic variation Humans Least-Squares Analysis Likelihood Functions Linear Models Male Mendelian Randomization Analysis Random Allocation Risk Factors Vital Capacity
Maximum-likelihood determination of anomalous substructures.
A fast Fourier transform (FFT) method is described for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by X-ray single-wavelength anomalous...
Neural correlates of somatoform disorders from a meta-analytic perspective on neuroimaging studies.
Somatoform disorders (SD) are common medical disorders with prevalence rates between 3.5% and 18.4%, depending on country and medical setting. SD as outlined in the ICD-10 exhibits various biological, social, and psychological...
ALE Activation likelihood estimation anterior cingulate cortex Insula MRI Meta-Analysis Middle frontal gyrus Neuroimaging posterior cingulate cortex Premotor area Somatoform disorders Somatoform pain disorders Supplementary motor cortex Brain Brain Mapping Databases Bibliographic Female Humans Likelihood Functions Magnetic Resonance Imaging Male Neuroimaging Somatoform Disorders
Evolutionary history of the recruitment of conserved developmental genes in association to the formation and diversification of a novel trait.
Leila T Shirai, Suzanne V Saenko, Roberto A Keller, Maria A Jerónimo, Paul M Brakefield, Henri Descimon, Niklas Wahlberg, Patrícia Beldade
May 28, 2012
The impact of quantitative optimization of hybridization conditions on gene expression analysis.
Peter Sykacek, David P Kreil, Lisa A Meadows, Richard P Auburn, Bettina Fischer, Steven Russell, Gos Micklem
May 26, 2011
Penalized likelihood estimation of the proportional hazards model for survival data with interval censoring.
This paper considers the problem of semi-parametric proportional hazards model fitting where observed survival times contain event times and also interval, left and right censoring times. Although this is not a new topic, many...
Singular value decomposition analysis of back projection operator of maximum likelihood expectation maximization PET image reconstruction.
Background In emission tomography maximum likelihood expectation maximization reconstruction technique has replaced the analytical approaches in several applications. The most important drawback of this iterative method is its...
Macromolecular X-ray structure determination using weak, single-wavelength anomalous data.
Gábor Bunkóczi, Airlie J McCoy, Nathaniel Echols, Ralf W Grosse-Kunstleve, Paul D Adams, James M Holton, Randy J Read, Thomas C Terwilliger
May 11, 2020
We describe a likelihood-based method for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by single-wavelength anomalous diffraction (SAD)...
Mixture distributions in multi-state modelling
In many studies, interest lies in determining whether members of the study population will undergo a particular event of interest. Such scenarios are often termed 'mover-stayer' scenarios, and interest lies in modelling two...
Extending Bayesian back-calculation to estimate age and time specific HIV incidence.
Francesco Brizzi, Paul J Birrell, Martyn T Plummer, Peter Kirwan, Alison E Brown, Valerie C Delpech, O Noel Gill, Daniela De Angelis
Mar 14, 2019
CD4-based multi-state back-calculation methods are key for monitoring the HIV epidemic, providing estimates of HIV incidence and diagnosis rates by disentangling their inter-related contribution to the observed surveillance...
Language networks in aphasia and health
Aphasia recovery post-stroke is classically and most commonly hypothesised to rely on regions that were not involved in language premorbidly, through 'neurocomputational invasion' or engagement of 'quiescent homologues'....
Maximizing the biochemical resolving power of fluorescence microscopy.
Most recent advances in fluorescence microscopy have focused on achieving spatial resolutions below the diffraction limit. However, the inherent capability of fluorescence microscopy to non-invasively resolve different...
Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
Ferry Hagen, Paulo C Ceresini, Itzhack Polacheck, Hansong Ma, Filip Van Nieuwerburgh, Toni Gabaldón, Sarah Kagan, E Rhiannon Pursall, Hans L Hoogveld, Leo JJ van Iersel, Gunnar W Klau, Steven M Kelk, Leen Stougie, Karen H Bartlett, Kerstin Voelz, Leszek P Pryszcz, Elizabeth Castañeda, Marcia Lazera, Wieland Meyer, Dieter Deforce, Jacques F Meis, Robin C May, Corné HW Klaassen, Teun Boekhout
Oct 22, 2019
Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy...
Animals Brazil British Columbia Cells Cultured Cryptococcosis Cryptococcus gattii Disease Outbreaks Genes Fungal Humans Likelihood Functions MACROPHAGES Mice Mice Inbred BALB C Molecular Sequence Data Multilocus Sequence Typing Mycological Typing Techniques Northwestern United States Phylogeny Polymorphism Restriction Fragment Length Trees Tropical Climate Virulence
Coping with COVID-19
The COVID-19 pandemic might lead to more mental health problems. However, few studies have examined sleep problems, depression, and posttraumatic symptoms among the general adult population during the COVID-19 outbreak, and...
covid-19 Post-Traumatic Stress Symptoms (PTSS) Depression Insomnia Mental Health Adaptation Psychological Adolescent Adult Asian People Betacoronavirus covid-19 China Coronavirus Infections Depression Disease Outbreaks Female Humans Likelihood Functions Male Mental Health Middle Aged Pandemics Pneumonia Viral SARS-CoV-2 Sleep Wake Disorders Stress Disorders Post-Traumatic Surveys and Questionnaires Young Adult
Likelihood-based molecular-replacement solution for a highly pathological crystal with tetartohedral twinning and sevenfold translational noncrystallographic symmetry.
Translational noncrystallographic symmetry (tNCS) is a pathology of protein crystals in which multiple copies of a molecule or assembly are found in similar orientations. Structure solution is problematic because this breaks the...
commensurate modulation maximum likelihood Molecular replacement pseudo-symmetry Translational Noncrystallographic Symmetry Anilino Naphthalenesulfonates Crystallography X-Ray Fluorescent Dyes Hypericum Ligands Likelihood Functions Models Molecular Plant Proteins Protein Binding Protein Conformation Protein Multimerization
Varying-coefficient models for longitudinal processes with continuous-time informative dropout.
Dropout is a common occurrence in longitudinal studies. Building upon the pattern-mixture modeling approach within the Bayesian paradigm, we propose a general framework of varying-coefficient models for longitudinal data with...
Lineage-specific gene radiations underlie the evolution of novel betalain pigmentation in Caryophyllales.
Samuel F Brockington, Ya Yang, Fernando Gandia-Herrero, Sarah Covshoff, Julian M Hibberd, Rowan F Sage, Gane KS Wong, Michael J Moore, Stephen A Smith
Jun 05, 2015
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