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Results: 36
Systematic lymphadenectomy versus sampling of ipsilateral mediastinal lymph-nodes during lobectomy for non-small-cell lung cancer
Sahar Mokhles, Fergus Macbeth, Tom Treasure, Riad N Younes, Robert C Rintoul, Francesca Fiorentino, Ad JJC Bogers, Johanna JM Takkenberg
Sep 08, 2018
OBJECTIVES: To re-examine the evidence for recommendations for complete dissection versus sampling of ipsilateral mediastinal lymph nodes during lobectomy for cancer. METHODS: We searched for randomized trials of systematic...
Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics.
Harry L Horsnell, Robert J Tetley, Henry de Belly, Spyridon Makris, Lindsey J Millward, Agnesska C Benjamin, Lucas A Heeringa, Charlotte M de Winde, Ewa K Paluch, Yanlan Mao, Sophie E Acton
Aug 06, 2022
Emergent physical properties of tissues are not readily understood by reductionist studies of their constituent cells. Here, we show molecular signals controlling cellular, physical, and structural properties and collectively...
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
Naomi McGovern, Amanda Shin, Gillian Low, Donovan Low, Kaibo Duan, Leong Jing Yao, Rasha Msallam, Ivy Low, Nurhidaya Binte Shadan, Hermi R Sumatoh, Erin Soon, Josephine Lum, Esther Mok, Sandra Hubert, Peter See, Edwin Huang Kunxiang, Yie Hou Lee, Baptiste Janela, Mahesh Choolani, Citra Nurfarah Zaini Mattar, Yiping Fan, Tony Kiat Hon Lim, Dedrick Kok Hong Chan, Ker-Kan Tan, John Kit Chung Tam, Christopher Schuster, Adelheid Elbe-Bürger, Xiao-Nong Wang, Venetia Bigley, Matthew Collin, Muzlifah Haniffa, Andreas Schlitzer, Michael Poidinger, Salvatore Albani, Anis Larbi, Evan W Newell, Jerry Kok Yen Chan, Florent Ginhoux
Jun 18, 2018
During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food...
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
May 13, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
Theobald Smith, 1906
The Rockefeller University
Jan 01, 0001
Theobald Smith. The Parasitism of the Tubercle Bacillus and Its Bearing on Infection and Immunity
Lecture delivered March 10th, 1906
Published by: J.B. Lippincott Company
PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.
Activation of T lymphocytes by peptide/major histocompatibility complex on antigen-presenting cells (APCs) involves dynamic contacts between the two cells, during which T cells undergo marked morphological changes. These...
Actin Depolymerizing Factors Animals Antigen-Presenting Cells CD4-Positive T-Lymphocytes Cell Adhesion Cell Communication Cell Movement Cell Shape Class I Phosphatidylinositol 3-Kinases Dendritic Cells GTP-Binding Proteins Intercellular Adhesion Molecule-1 Lymph Nodes Lymphocyte Function-Associated Antigen-1 Mice Inbred C57BL Phosphatidylinositol 3-Kinases Protein Binding Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell
Right hemicolectomy with complete mesocolic excision is safe, leads to an increased lymph node yield and to increased survival
Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry.
Jennie HM Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M Tannahill, Andrew R Beaton, Danielle M Gerlag, Caroline OS Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M Dayan, Timothy IM Tree
Jan 03, 2020
Background: Ultrasound guided sampling of human lymph node (LN) combined with advanced flow cytometry allows phenotypic analysis of multiple immune cell subsets. These may provide insights into immune processes and responses to...
Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers.
Elizabeth F Wallin, Elaine C Jolly, Ondřej Suchánek, J Andrew Bradley, Marion Espéli, David RW Jayne, Michelle A Linterman, Kenneth GC Smith
Oct 07, 2014
Adolescent Adult Aged Antibodies Monoclonal Murine-Derived Antibody Formation Antigens CD19 B-Lymphocytes CD57 Antigens Cell Differentiation Cells Cultured Coculture Techniques Female Flow Cytometry Germinal Center Humans Immunologic Factors Lymph Nodes Lymphocyte Count Male Middle Aged Receptors CXCR5 Rituximab T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Tumor Necrosis Factor Receptor Superfamily Member 7 Young Adult
Cells of the human intestinal tract mapped across space and time.
Rasa Elmentaite, Natsuhiko Kumasaka, Kenny Roberts, Aaron Fleming, Emma Dann, Hamish W King, Vitalii Kleshchevnikov, Monika Dabrowska, Sophie Pritchard, Liam Bolt, Sara F Vieira, Lira Mamanova, Ni Huang, Francesca Perrone, Issac Goh Kai'En, Steven N Lisgo, Matilda Katan, Steven Leonard, Thomas RW Oliver, C Elizabeth Hook, Komal Nayak, Lia S Campos, Cecilia Domínguez Conde, Emily Stephenson, Justin Engelbert, Rachel A Botting, Krzysztof Polanski, Stijn van Dongen, Minal Patel, Michael D Morgan, John C Marioni, Omer Ali Bayraktar, Kerstin B Meyer, Xiaoling He, Roger A Barker, Holm H Uhlig, Krishnaa T Mahbubani, Kourosh Saeb-Parsy, Matthias Zilbauer, Menna R Clatworthy, Muzlifah Haniffa, Kylie R James, Sarah A Teichmann
Sep 07, 2021
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we...
Tumor-induced stromal reprogramming drives lymph node transformation.
Animals Cell Differentiation Cell Movement Cell Transformation Neoplastic Cellular Reprogramming Chemokine CCL21 Cytokines Extracellular Matrix Female FIBROBLASTS Interleukin-7 Lymph Nodes Melanoma Experimental Mice Mice Inbred C57BL Neoplasm Metastasis Neoplasms Signal Transduction Stromal Cells Tissue Array Analysis Transcriptome Tumor Microenvironment
Axillary tumour burden in women with one abnormal node on ultrasound compared to women with multiple abnormal nodes.
S Puri, N Sharma, RG Newcombe, M Kaushik, M Al-Attar, S Pascaline, M Hajaj, MG Wallis, B Elsberger, A Goyal
Mar 23, 2018
AIM: To determine if the number of abnormal nodes seen on preoperative axillary ultrasound (AUS) is a predictor of the number of positive nodes at histology for women with needle-biopsy-proven positive nodes. MATERIALS AND...
Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium.
T Goranova, D Ennis, AM Piskorz, G Macintyre, LA Lewsley, J Stobo, C Wilson, D Kay, RM Glasspool, M Lockley, E Brockbank, A Montes, A Walther, S Sundar, R Edmondson, GD Hall, A Clamp, C Gourley, M Hall, C Fotopoulou, H Gabra, S Freeman, L Moore, M Jimenez-Linan, J Paul, JD Brenton, IA McNeish
Nov 13, 2018
BACKGROUND: Investigating tumour evolution and acquired chemotherapy resistance requires analysis of sequential tumour material. We describe the feasibility of obtaining research biopsies in women with relapsed ovarian...
Adult Aged Aged 80 and over Carcinoma Class I Phosphatidylinositol 3-Kinases DNA Mutational Analysis DNA Neoplasm ErbB Receptors Feasibility Studies Female Humans Image-guided biopsy Liver Liver Neoplasms Lymph Nodes Lymphatic Metastasis Middle Aged Neoplasm Grading Omentum Ovarian Neoplasms PTEN Phosphohydrolase Pain Peritoneal Neoplasms Peritoneum Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins p21(ras) Tumor Suppressor Protein p53
IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.
Hung-Chang Chen, Nils Eling, Celia Pilar Martinez-Jimenez, Louise McNeill O'Brien, Valentina Carbonaro, John C Marioni, Duncan T Odom, Maike de la Roche
Jun 03, 2019
IL-7 Ageing lymph node tumour response γδ T-cell lineage aging Animals Carcinoma Lewis Lung Cell Differentiation Cell Lineage Gene Expression Regulation Neoplastic Immunophenotyping Interleukin-17 Interleukin-7 Lymph Nodes Mice Mice Inbred C57BL Receptors Antigen T-Cell gamma-delta Signal Transduction T-Lymphocyte Subsets Tumor Burden
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift.
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence SC Lok, Jeremy A Pike, Jennifer Mueller-Winkler, Thomas W Dennison, John R Ferdinand, Cameron JM Burnett, Juan C Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor LJ Tybulewicz, Antal Rot, Anja E Hauser, Menna R Clatworthy, Kai-Michael Toellner
Jun 07, 2022
Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. Here we follow the migratory...
Multiparametric MRI - local staging of prostate cancer and beyond.
Background Accurate local staging is critical for treatment planning and prognosis in patients with prostate cancer (PCa). The primary aim is to differentiate between organ-confined and locally advanced disease with the latter...
Axillary Surgery Following Neoadjuvant Chemotherapy - Multidisciplinary Guidance From the Association of Breast Surgery, Faculty of Clinical Oncology of the Royal College of Radiologists, UK Breast Cancer Group, National Coordinating Committee for Breast Pathology and British Society of Breast Radiology.
AIMS: These multidisciplinary guidelines aim to provide clinically helpful, evidence-based recommendations on the surgical management of the axilla in patients who have received neo-adjuvant chemotherapy for early breast cancer....
Linear endobronchial ultrasonography
Linear endobronchial ultrasound was first described in 2003. Since then the technique has spread rapidly and has now become an established practice in many centres as the first-line mediastinal investigation for the diagnosis...
Bronchoscopy Health Economist Histology/Cytology Lung cancer Non-Small Cell Lung Cancer Sarcoidosis Tuberculosis Bronchoscopes Endoscopic Ultrasound-Guided Fine Needle Aspiration Endosonography Humans Lung Neoplasms Lymph Nodes Lymphatic Metastasis Lymphoma Mediastinum Neoplasm Staging Sarcoidosis Tuberculosis Lymph Node
Is breast implant-associated anaplastic large cell lymphoma a hazard of breast implant surgery?
Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.
Edward JD Greenwood, Fabian Schmidt, Ivanela Kondova, Henk Niphuis, Vida L Hodara, Leah Clissold, Kirsten McLay, Bernadette Guerra, Sharon Redrobe, Luis D Giavedoni, Robert E Lanford, Krishna K Murthy, François Rouet, Jonathan L Heeney
Aug 28, 2015
Animals Ape Diseases Autoimmune Diseases Biomarkers CD4 Lymphocyte Count Female HIV-1 Hyperplasia Lentivirus Infections Lentiviruses Primate Lymph Nodes Male Myxovirus Resistance Proteins Neopterin Pan troglodytes Peptide Fragments Receptors TNF-Related Apoptosis-Inducing Ligand Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus Thrombocytopenia Viral Load beta 2-Microglobulin
Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.
Paula Kuo, Siok Min Teoh, Zewen K Tuong, Graham R Leggatt, Stephen R Mattarollo, Ian H Frazer
Aug 20, 2021
"High-risk" human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and disrupting cell cycle termination. Murine skin expressing...
APC CIN HPV16 Keratinocytes Retinoblastoma Protein skin grafting Animals Antigen-Presenting Cells Disease Models Animal epidermis Female Human papillomavirus 16 Humans Hyperplasia Keratinocytes Lymph Nodes Mice Mice Inbred C57BL Mice Transgenic Papillomavirus E7 Proteins Papillomavirus Infections Protein Binding Retinoblastoma Binding Proteins Retinoblastoma Protein
How should performance in EBUS mediastinal staging in lung cancer be measured?
Matthew Evison, Philip Crosbie, Neal Navani, Matthew Callister, Robert C Rintoul, David Baldwin, Richard Booton
Sep 05, 2018
There has been a paradigm shift in mediastinal staging algorithms in non-small cell lung cancer over the last decade in the United Kingdom (UK). This has seen endoscopic nodal staging (predominantly endobronchial ultrasound...
Increased Frequency of CD4+ Follicular Helper T and CD8+ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.
Dornatien Chuo Anang, Tamara H Ramwadhdoebe, Janine S Hähnlein, Bo van Kuijk, Noortje Smits, Krijn P van Lienden, Mario Maas, Daniëlle M Gerlag, Paul P Tak, Niek de Vries, Lisa GM van Baarsen
Mar 28, 2022
Follicular T helper cells (Tfh cells) provide key B-cell help and are essential in germinal center formation and (auto) antibody generation. To gain more insight into their role during the earliest phase of rheumatoid arthritis...
A central review of histopathology reports after breast cancer neoadjuvant chemotherapy in the neo-tango trial.
E Provenzano, A-L Vallier, R Champ, K Walland, S Bowden, A Grier, N Fenwick, J Abraham, M Iddawela, C Caldas, L Hiller, J Dunn, HM Earl
Oct 26, 2020
BACKGROUND: Neo-tAnGo, a National Cancer Research Network (NCRN) multicentre randomised neoadjuvant chemotherapy trial in early breast cancer, enroled 831 patients in the United Kingdom. We report a central review of...
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