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Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.
Niccolo Bolli, Hervé Avet-Loiseau, David C Wedge, Peter Van Loo, Ludmil B Alexandrov, Inigo Martincorena, Kevin J Dawson, Francesco Iorio, Serena Nik-Zainal, Graham R Bignell, Jonathan W Hinton, Yilong Li, Jose MC Tubio, Stuart McLaren, Sarah O' Meara, Adam P Butler, Jon W Teague, Laura Mudie, Elizabeth Anderson, Naim Rashid, Yu-Tzu Tai, Masood A Shammas, Adam S Sperling, Mariateresa Fulciniti, Paul G Richardson, Giovanni Parmigiani, Florence Magrangeas, Stephane Minvielle, Philippe Moreau, Michel Attal, Thierry Facon, P Andrew Futreal, Kenneth C Anderson, Peter J Campbell, Nikhil C Munshi
Nov 29, 2018
Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse 84 myeloma samples....
Adult Aged Antigens Nuclear Cohort Studies DNA Copy Number Variations Early Growth Response Protein 1 evolution Molecular Exome GTP Phosphohydrolases Genetic Heterogeneity Humans Lymphotoxin-beta Membrane Proteins Middle Aged multiple myeloma Mutation Mutation Missense Nerve Tissue Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins p21(ras) Receptors Immunologic Sequence Analysis DNA Transcription Factors Tumor Suppressor Protein p53 ras Proteins