Search
Results: 222
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Michael E Reschen, Da Lin, Anil Chalisey, Elizabeth J Soilleux, Christopher A O'Callaghan
Dec 17, 2018
BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with...
Atherosclerosis Expression quantitative trait locus (eQTL) Functional genomics genetic disease Genetic polymorphism Genomics Low-density lipoprotein (LDL) Myocardial Infarction Oxidized low density lipoprotein (oxLDL) PHACTR1 Adult Aged Alleles Atherosclerosis Coronary Artery Disease Coronary Vessels Endothelial Cells Gene Expression Regulation Gene-Environment Interaction Genotype Humans Inflammation Lipopolysaccharides MACROPHAGES Microfilament Proteins Middle Aged Muscle Smooth Vascular Polymorphism Single Nucleotide Tumor Necrosis Factor-alpha Young Adult
Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Dylan G Ryan, Michael P Murphy, Christian Frezza, Hiran A Prag, Edward T Chouchani, Luke A O'Neill, Evanna L Mills
Feb 12, 2019
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new insights into underlying mechanisms of disease. Metabolites traditionally associated with...
Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Parimal Samir, Sannula Kesavardhana, Deanna M Patmore, Sebastien Gingras, RK Subbarao Malireddi, Rajendra Karki, Clifford S Guy, Benoit Briard, David E Place, Anannya Bhattacharya, Bhesh Raj Sharma, Amanda Nourse, Sharon V King, Aaron Pitre, Amanda R Burton, Stephane Pelletier, Richard J Gilbertson, Thirumala-Devi Kanneganti
Oct 25, 2019
RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.
Zewen Kelvin Tuong, Patrick Lau, Ximing Du, Nicholas D Condon, Joel M Goode, Tae Gyu Oh, Jeremy C Yeo, George EO Muscat, Jennifer L Stow
Sep 02, 2019
Nuclear hormone receptors have important roles in the regulation of metabolic and inflammatory pathways. The retinoid-related orphan receptor alpha (Rorα)-deficient staggerer (sg/sg) mice display several phenotypes indicative of...
Animals Bone Marrow Cells Cells Cultured Chromatography Thin Layer Drug Inverse Agonism Hydroxycholesterols Lipid Droplets Lipid Metabolism Lipids MACROPHAGES Male Mice Mice Inbred C3H Mice Knockout Nuclear Receptor Subfamily 1 Group F Member 1 RNA Interference RNA Messenger Receptors LDL Steroid Hydroxylases Up-Regulation
Effect of colony morphology variation of Burkholderia pseudomallei on intracellular survival and resistance to antimicrobial environments in human macrophages in vitro.
Sarunporn Tandhavanant, Aunchalee Thanwisai, Direk Limmathurotsakul, Sunee Korbsrisate, Nicholas Pj Day, Sharon J Peacock, Narisara Chantratita
Jun 16, 2011
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Valeria Radjabova, Piero Mastroeni, Karsten Skjødt, Paola Zaccone, Bernard de Bono, Jane C Goodall, Edwin R Chilvers, Jatinder K Juss, Des C Jones, John Trowsdale, Alexander David Barrow
Jul 29, 2015
Amino Acid Sequence Animals Base Sequence CD4-Positive T-Lymphocytes Cell Line Cytokines Dendritic Cells Female Granulocytes HEK293 Cells HLA Antigens Humans Inflammation Ligands Lipopolysaccharides Lymphocyte Activation MACROPHAGES Mice Mice Inbred C57BL Mice Inbred NOD Molecular Sequence Data Neutrophils Protein Transport Receptors Immunologic Recombinant Fusion Proteins Signal Transduction
Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.
Si Ming Man, Andrew Ekpenyong, Panagiotis Tourlomousis, Sarra Achouri, Eugenia Cammarota, Katherine Hughes, Alessandro Rizzo, Gilbert Ng, John A Wright, Pietro Cicuta, Jochen R Guck, Clare E Bryant
Feb 03, 2015
ASC ROS caspase-1 Cytoskeleton innate immunity Actin Cytoskeleton Actins Animals Apoptosis Regulatory Proteins Bone Marrow Cells Calcium-Binding Proteins Caspase 1 Cytoskeleton Hydrogen Peroxide Immunity Innate Inflammasomes Inflammation Interleukin-1beta MACROPHAGES Mice Mice Transgenic Microscopy Confocal Neutrophils Polymerization Reactive Oxygen Species Salmonella Infections Salmonella typhimurium
Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo.
Steven Levitte, Kristin N Adams, Russell D Berg, Christine L Cosma, Kevin B Urdahl, Lalita Ramakrishnan
Sep 09, 2016
Animals Anti-Bacterial Agents Bacterial Proteins Carboxylic Acids Cells Cultured Disease Models Animal Host-Pathogen Interactions Lysosomes MACROPHAGES Mice Inbred C57BL Microbial Viability Mycobacterium Infections Nontuberculous Mycobacterium marinum Stress Physiological Virulence Factors Zebrafish
Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models.
Joel Chappell, Jennifer L Harman, Vagheesh M Narasimhan, Haixiang Yu, Kirsty Foote, Benjamin D Simons, Martin R Bennett, Helle F Jørgensen
Nov 22, 2016
Atherosclerosis lineage-tracing MACROPHAGES Neointima Phenotype vascular diseases vascular smooth muscle Animals Atherosclerosis Cell Proliferation Disease Models Animal Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Mice Transgenic Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Vascular System Injuries
A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.
Amy TY Yeung, Yoon Ha Choi, Amy HY Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert EW Hancock, Gordon Dougan
Oct 14, 2020
A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14...
The Rab32/BLOC-3-dependent pathway mediates host defense against different pathogens in human macrophages.
Massimiliano Baldassarre, Virtu Solano-Collado, Arda Balci, Rosa A Colamarino, Ivy M Dambuza, Delyth M Reid, Heather M Wilson, Gordon D Brown, Subhankar Mukhopadhyay, Gordon Dougan, Stefania Spanò
Feb 19, 2021
Macrophages provide a first line of defense against microorganisms, and while some mechanisms to kill pathogens such as the oxidative burst are well described, others are still undefined or unknown. Here, we report that the...
Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells.
Elizabeth Rivers, Rajeev Rai, Jonas Lötscher, Michael Hollinshead, Gasper Markelj, James Thaventhiran, Austen Worth, Alessia Cavazza, Christoph Hess, Mona Bajaj-Elliott, Adrian J Thrasher
Feb 01, 2021
The actin cytoskeletal regulator Wiskott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflammasome axis in innate murine immune cells. Here, we show that WASp deficiency is associated with...
Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission.
Kevin K Takaki, Gabriel Rinaldi, Matthew Berriman, Antonio J Pagán, Lalita Ramakrishnan
Feb 03, 2021
Schistosome eggs provoke the formation of granulomas, organized immune aggregates, around them. For the host, the granulomatous response can be both protective and pathological. Granulomas are also postulated to facilitate egg...
Schistosoma egg extrusion Schistosoma egg translocation Schistosoma mansoni granulomas Helminths Humans innate immunity miracidia Schistosomiasis Zebrafish Animals Feces Granuloma Granuloma Foreign-Body Humans Immunity Innate Intestines MACROPHAGES Mice Ovum Schistosoma mansoni Schistosomiasis mansoni Zebrafish
Distribution of Microglia in the Central Nervous System of Embryonic and Larval Amphibians
Sarah Weggeman
Jan 01, 0001
Microglial cells are responsible for inflammatory and immune responses in many living organisms. These cells originate from macrophages, which are resident cells of the central nervous system (CNS). Although microglial cells are...
central nervous system (CNS) Microglia MACROPHAGES Amphibians Axolotl larvae Biology Developmental Neuroscience Life Sciences Molecular and Cellular Neuroscience
Published by: Ursinus College
The Effects of Wls Deletion in Macrophages on Muscle Repair
Patrick Rafferty
Jan 01, 0001
Few treatments for muscle injury exist. The treatments that do exist are aimed at limiting pain and inflammation. However, recent evidence demonstrates that inflammatory cells speed healing after injury. Following injury...
skeletal muscle injury Wnt MACROPHAGES Myocyte Regeneration Inflammation Cells Medicine and Health Sciences Physiological Processes
Published by: Ursinus College
Hypoxia and tissue destruction in pulmonary TB.
Moerida Belton, Sara Brilha, Roido Manavaki, Francesco Mauri, Kuldip Nijran, Young T Hong, Neva H Patel, Marcin Dembek, Liku Tezera, Justin Green, Rachel Moores, Franklin Aigbirhio, Adil Al-Nahhas, Tim D Fryer, Paul T Elkington, Jon S Friedland
Jun 03, 2016
Tuberculosis Adult Biopsy Cell Hypoxia Cells Cultured Collagenases Epithelial Cells Female Gene Expression Regulation Humans Hypoxia-Inducible Factor 1 alpha Subunit Lung MACROPHAGES Male Matrix Metalloproteinase 1 Microscopy Confocal Middle Aged Mycobacterium tuberculosis Positron Emission Tomography Computed Tomography RNA Messenger Respiratory Mucosa Tuberculosis Pulmonary Up-Regulation Young Adult
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L Kempster, Gavin W Sewell, Svetlana Saveljeva, Jonathan W Ashcroft, Simon Clare, Subhankar Mukhopadhyay, Karen P Brown, Markus Tschurtschenthaler, Tim Raine, Brendan Doe, Edwin R Chilvers, Jules L Griffin, Nicole C Kaneider, R Andres Floto, Mauro D'Amato, Allan Bradley, Michael JO Wakelam, Gordon Dougan, Arthur Kaser
Aug 15, 2016
Adenosine Triphosphate Animals Arthritis Juvenile Bacteriolysis Cells Cultured Crohn Disease Energy Metabolism Fatty Acid Synthase Type I Genetic Predisposition to Disease Humans Infections Inflammasomes Intracellular Signaling Peptides and Proteins Leprosy Lipid Metabolism MACROPHAGES Mice Mice Inbred C57BL Mice Knockout NADPH Oxidases Oxidation-Reduction Polymorphism Single Nucleotide Proteins risk Shock Septic
Prospective functional classification of all possible missense variants in PPARG.
Amit R Majithia, Ben Tsuda, Maura Agostini, Keerthana Gnanapradeepan, Robert Rice, Gina Peloso, Kashyap A Patel, Xiaolan Zhang, Marjoleine F Broekema, Nick Patterson, Marc Duby, Ted Sharpe, Eric Kalkhoven, Evan D Rosen, Inês Barroso, Sian Ellard, UK Monogenic Diabetes Consortium, Sekar Kathiresan, Myocardial Infarction Genetics Consortium, Stephen O'Rahilly, UK Congenital Lipodystrophy Consortium, Krishna Chatterjee, Jose C Florez, Tarjei Mikkelsen, David B Savage, David Altshuler
Oct 20, 2016
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophages.
Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner, Kile Green, Rachel Dickinson, Xiao-Nong Wang, Donovan Low, Katie Best, Samuel Covins, Paul Milne, Sarah Pagan, Khadija Aljefri, Martin Windebank, Diego Miranda-Saavedra, Anis Larbi, Pavandip Singh Wasan, Kaibo Duan, Michael Poidinger, Venetia Bigley, Florent Ginhoux, Matthew Collin, Muzlifah Haniffa
Jun 18, 2018
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs...
Fibrillar beta-amyloid peptide A beta(1-40) activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase
Background: Alzheimer's disease is characterized by the accumulation of neuritic plaques, containing activated microglia and beta-amyloid peptides (A beta). Fibrillar A beta can activate microglia, resulting in production of...
The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.
Damien P Brown, Des C Jones, Katie J Anderson, Nicolas Lapaque, Robin A Buerki, John Trowsdale, Rachel L Allen
Jun 16, 2011
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
Petra Mlcochova, Katherine A Sutherland, Sarah A Watters, Cosetta Bertoli, Rob Am de Bruin, Jan Rehwinkel, Stuart J Neil, Gina M Lenzi, Baek Kim, Asim Khwaja, Matthew C Gage, Christiana Georgiou, Alexandra Chittka, Simon Yona, Mahdad Noursadeghi, Greg J Towers, Ravindra K Gupta
Sep 18, 2019
An unresolved question is how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle-associated proteins...
The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation.
Can Aztekin, Tom W Hiscock, Richard Butler, Francisco De Jesús Andino, Jacques Robert, John B Gurdon, Jerome Jullien
Jan 16, 2020
Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and inflammation can help develop strategies to...
|
|< |
< |
1 |