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Results: 7
The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer.
Alison Caldwell, Rachel Coleby, Cesar Tovar, Maximilian R Stammnitz, Young Mi Kwon, Rachel S Owen, Marios Tringides, Elizabeth P Murchison, Karsten Skjødt, Gareth J Thomas, Jim Kaufman, Tim Elliott, Gregory M Woods, Hannah VT Siddle
Nov 21, 2018
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1...
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.
Maximilian R Stammnitz, Tim HH Coorens, Kevin C Gori, Dane Hayes, Beiyuan Fu, Jinhong Wang, Daniel E Martin-Herranz, Ludmil B Alexandrov, Adrian Baez-Ortega, Syd Barthorpe, Alexandra Beck, Francesca Giordano, Graeme W Knowles, Young Mi Kwon, George Hall, Stacey Price, Ruth J Pye, Jose MC Tubio, Hannah VT Siddle, Sukhwinder Singh Sohal, Gregory M Woods, Ultan McDermott, Fengtang Yang, Mathew J Garnett, Zemin Ning, Elizabeth P Murchison
Mar 13, 2018
Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional...
DFTD Tasmanian devils Cancer Cancer evolution Cancer genomics CONSERVATION contagious cancer drug screening marsupials transmissible cancer Animals Cell Line Tumor Chromosomes Mammalian Clone Cells Facial Neoplasms Female Gene Dosage Gene Editing Immunity Male Marsupialia Mutation Receptors Platelet-Derived Growth Factor
Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
C Tovar, RJ Pye, A Kreiss, Y Cheng, GK Brown, J Darby, RC Malley, HVT Siddle, K Skjødt, J Kaufman, A Silva, A Baz Morelli, AT Papenfuss, LM Corcoran, JM Murphy, MJ Pearse, K Belov, AB Lyons, GM Woods
Apr 25, 2017
Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC.
Yuanyuan Cheng, Andrew Stuart, Katrina Morris, Robyn Taylor, Hannah Siddle, Janine Deakin, Menna Jones, Chris T Amemiya, Katherine Belov
Aug 08, 2012
A second transmissible cancer in Tasmanian devils.
Ruth J Pye, David Pemberton, Cesar Tovar, Jose MC Tubio, Karen A Dun, Samantha Fox, Jocelyn Darby, Dane Hayes, Graeme W Knowles, Alexandre Kreiss, Hannah VT Siddle, Kate Swift, A Bruce Lyons, Elizabeth P Murchison, Gregory M Woods
Dec 04, 2015
Tasmanian devil Tasmanian devil facial tumor disease contagious cancer transmissible cancer Alleles Animals Chromosome Breakage Cytogenetic Analysis Exons Genome Geography Haplotypes Karyotyping Marsupialia Microsatellite Repeats Molecular Sequence Data Neoplasms Polymorphism Single Nucleotide Tasmania X Chromosome
Mechanisms of Choice in X-Chromosome Inactivation.
Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate....
Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils.
Young Mi Kwon, Kevin Gori, Naomi Park, Nicole Potts, Kate Swift, Jinhong Wang, Maximilian R Stammnitz, Naomi Cannell, Adrian Baez-Ortega, Sebastien Comte, Samantha Fox, Colette Harmsen, Stewart Huxtable, Menna Jones, Alexandre Kreiss, Clare Lawrence, Billie Lazenby, Sarah Peck, Ruth Pye, Gregory Woods, Mona Zimmermann, David C Wedge, David Pemberton, Michael R Stratton, Rodrigo Hamede, Elizabeth P Murchison
Oct 22, 2020