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BACKGROUND: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue...

Foetal programming Gestational diabetes Maternal obesity Metformin Sex differences White adipose tissue Adiposity Animals Animals Newborn Diabetes Gestational Female Male Metformin Mice Mice Inbred C57BL obesity Maternal Pregnancy prenatal exposure delayed effects Sex Factors

Pregnancy Diet Gestational diabetes neonatal growth Maternal obesity neonatal outcomes randomised controlled trial large-for-gestational age dietary intervention Study Protocol neonatal hypoglycaemia continuous glucose monitoring (CGM) maternal or gestational weight gain

continuous glucose monitoring (CGM) Diet dietary intervention Gestational diabetes large-for-gestational age Maternal obesity maternal or gestational weight gain neonatal growth neonatal hypoglycaemia neonatal outcomes Pregnancy randomised controlled trial Study Protocol Blood Glucose Cesarean Section Diabetes Gestational Diet Reducing Female Gestational Weight Gain Humans obesity Pregnancy Pregnancy Complications Pregnant Women Risk Factors Weight Reduction Programs

article Beta cell islets Maternal obesity Type 2 diabetes

Maternal obesity is a global problem that increases the risk of short- and long-term adverse outcomes for mother and child, many of which are linked to gestational diabetes mellitus. Effective treatments are essential to prevent...

developmental programming Gestational diabetes mellitus Maternal obesity Metformin Placenta Animals Diet High-Fat Female Fetal Growth Retardation Glucose Intolerance Humans Infectious Disease Transmission Vertical Metformin Mice obesity Maternal Placenta Pregnancy

We determined the effects of maternal diet-induced obesity on offspring adipose tissue insulin signalling and miRNA expression in the aetiology of insulin resistance in later life. Although body composition and glucose tolerance...

Adipose Tissue DEXA dual energy X-ray absorptiometry Hyperinsulinemia IRS1 IRβ insulin receptor-beta Maternal obesity PI3K phosphotidylinositol 3-kinase UTR untranslated region miRNA microRNA MicroRNAs

article Beta cell islets Maternal obesity Type 2 diabetes

Background

Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose...

Metformin Sex differences Gestational diabetes White adipose tissue Maternal obesity Foetal programming

Biochemistry chemical biology developmental biology Fetal Heart heart metabolism lipidomics Maternal obesity MOUSE transcriptomics Animals Female Fetus Lipid Metabolism lipidomics Male Mice Myocardium obesity Maternal Pregnancy Transcriptome

RESEARCH ARTICLE Biochemistry and Chemical Biology developmental biology Maternal obesity Fetal Heart heart metabolism lipidomics transcriptomics MOUSE

Gestational diabetes mellitus (GDM) annually affects 35,000 pregnancies in the United Kingdom, causing suboptimal health outcomes to the mother and child. Obesity and excessive gestational weight gain are risk factors for GDM....

Gestational diabetes Pregnancy Study Protocol randomised controlled trial large-for-gestational age Diet dietary intervention maternal or gestational weight gain continuous glucose monitoring (CGM) neonatal outcomes neonatal hypoglycaemia neonatal growth Maternal obesity

Appetite developmental programming Ghrelin Glucose homeostasis Insulin intervention Leptin Maternal obesity obesity Reward Animals Female Fetus Ghrelin Humans Insulin Leptin obesity Pregnancy Pregnancy Complications prenatal exposure delayed effects

Abstract: Aims/hypothesis: Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus...

article ER stress glucose metabolism Lunapark Maternal obesity miR-126-3p Nutritional programming

Beta cell islets Maternal obesity Type 2 diabetes Adenosine Triphosphate Animals Apoptosis Blotting Western DNA Mitochondrial Diabetes mellitus Type 2 Female Fluorescent Antibody Technique Islets of Langerhans Male Mice Mice Inbred C57BL Microscopy Electron Transmission obesity Maternal Oxygen Consumption Pregnancy Reverse Transcriptase Polymerase Chain Reaction Sex Characteristics

At the time of its discovery and characterization in 1994, leptin was mostly considered a metabolic hormone able to regulate body weight and energy homeostasis. However, in recent years, a great deal of literature has revealed...

epigenetics Leptin Maternal obesity oocyte quality ovarian leptin resistance

Hypothalamus Insulin Maternal obesity Neurogenesis Notch Animals Arcuate Nucleus of Hypothalamus Body Weight Brain Diet High-Fat Feeding Behavior Female Fetus Gene Expression Gene Expression Regulation Developmental Hypothalamus Insulin Insulin Resistance Male Maternal-Fetal Exchange Mice Mice Inbred C57BL Neural Stem Cells Neurons obesity obesity Maternal Pregnancy prenatal exposure delayed effects Weight Gain

ER stress glucose metabolism Lunapark Maternal obesity Nutritional programming miR-126-3p 3T3-L1 Cells Adipocytes Adipose Tissue Animals Blood Glucose Disease Models Animal Down-Regulation Endoplasmic reticulum stress Female Homeodomain Proteins Insulin Receptor Substrate Proteins Insulin Resistance Mice Mice Inbred C57BL MicroRNAs obesity Maternal Phenotype Pregnancy prenatal exposure delayed effects Signal Transduction

Background: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue...

Gestational diabetes Foetal programming Metformin Maternal obesity White adipose tissue Sex differences

developmental programming Fatty Liver Gestational diabetes Inflammation Maternal obesity Metformin White adipose tissue Humans Pregnancy Animals Mice Child Male Female Adult Infant Metformin Glucose Diabetes mellitus Type 2 Mice Inbred C57BL obesity Body composition Diabetes Gestational Fatty Liver Inflammation Lipids prenatal exposure delayed effects Diet High-Fat