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Results: 6
MC3R links nutritional state to childhood growth and the timing of puberty.
BYH Lam, A Williamson, S Finer, FR Day, JA Tadross, A Gonçalves Soares, K Wade, P Sweeney, MN Bedenbaugh, DT Porter, A Melvin, KLJ Ellacott, RN Lippert, S Buller, J Rosmaninho-Salgado, GKC Dowsett, KE Ridley, Z Xu, I Cimino, D Rimmington, K Rainbow, K Duckett, S Holmqvist, A Khan, X Dai, EG Bochukova, Genes & Health Research Team, RC Trembath, HC Martin, AP Coll, DH Rowitch, NJ Wareham, DA van Heel, N Timpson, RB Simerly, KK Ong, RD Cone, C Langenberg, JRB Perry, GS yeo, S O'Rahilly
Oct 25, 2021
The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development1. The central melanocortin system acts through melanocortin 4...
Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.
Agatha A van der Klaauw, Julia M Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M Trowse, Naresh Subramanian, Stephen O'Rahilly, Paul C Fletcher, I Sadaf Farooqi
Oct 03, 2016
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
Agatha A van der Klaauw, Sophie Croizier, Edson Mendes de Oliveira, Lukas KJ Stadler, Soyoung Park, Youxin Kong, Matthew C Banton, Panna Tandon, Audrey E Hendricks, Julia M Keogh, Susanna E Riley, Sofia Papadia, Elana Henning, Rebecca Bounds, Elena G Bochukova, Vanisha Mistry, Stephen O'Rahilly, Richard B Simerly, INTERVAL, UK10K consortium, James EN Minchin, Inês Barroso, E Yvonne Jones, Sebastien G Bouret, I Sadaf Farooqi
Jan 29, 2019
Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants...
AGRP Neuropilins Plexins POMC Semaphorin 3s Hypothalamus obesity Adolescent Adult Animals Body Weight Cell Line Child Child Preschool Disease Models Animal Eating Energy Metabolism Female genetic variation Homeostasis Humans Hypothalamus Leptin Male Melanocortins Mice Mice Inbred C57BL Middle Aged Nerve Tissue Proteins Neurons obesity Receptors Cell Surface Semaphorins Young Adult Zebrafish
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.
Peter Kirwan, Richard G Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M Gribble, Frank Reimann, I Sadaf Farooqi, Stephen O'Rahilly, Florian T Merkle
Nov 13, 2018
OBJECTIVE: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are...
Human pluripotent stem cell Leptin MSH Neuropeptide obesity POMC Chromatography Liquid Female Homeostasis Humans Hypothalamus Leptin Male Mass Spectrometry Melanocortins Neurons Neuropeptides Pluripotent Stem Cells Pro-Opiomelanocortin Receptors Melanocortin Tandem Mass Spectrometry alpha-MSH beta-MSH