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The fidelity of cAMP in controlling numerous cellular functions rests crucially on the precise organization of cAMP microdomains that are sustained by the scaffolding properties of adenylyl cyclase. Earlier studies suggested...

Adenylyl cyclase Caveolin Cholesterol Lipid rafts plasma membrane cAMP Adenylyl Cyclases Bacterial Proteins Brefeldin A Bridged Bicyclo Compounds Heterocyclic Caveolin 1 Cyclic AMP Cytoskeleton Gene Expression Genes Reporter Green Fluorescent Proteins Guanine Nucleotide Exchange Factors HEK293 Cells Humans Luminescent Proteins Membrane Microdomains Mutagenesis Site-Directed Protein Transport RNA Small Interfering Recombinant Fusion Proteins Thiazolidines beta-Cyclodextrins

Cdc42 Rho GTPases Cancer metastasis Actin Cytoskeleton Animals Gene Expression Regulation Neoplastic Humans Membrane Microdomains Microtubules Mutation Neoplasms Protein Binding Signal Transduction Small Molecule Libraries cdc42 GTP-Binding Protein

Hematopoietic stem/progenitor cell (HSPC) homing occurs via cell adhesion mediated by spatiotemporally organized ligand-receptor interactions. Although molecules and biological processes involved in this multistep cellular...

E-Selectin Hematopoietic Stem Cells Humans Hyaluronan Receptors Membrane Microdomains Microfluidics Microscopy Microscopy Confocal NANOSTRUCTURES

COPII GTPase endoplasmic reticulum (ER) membrane bilayer membrane transport Amino Acid Substitution Animals COP-Coated Vesicles Caenorhabditis elegans Caenorhabditis elegans Proteins Endoplasmic Reticulum Enzyme Inhibitors GTP Phosphohydrolases GTPase-Activating Proteins Guanosine Triphosphate Guanylyl Imidodiphosphate Humans Lipid Bilayers Membrane Microdomains Microscopy Atomic Force Models Biological Monomeric GTP-Binding Proteins Mutation Organelle Shape RNA Interference Receptor Protein-Tyrosine Kinases Recombinant Proteins Vesicular Transport Proteins ras GTPase-Activating Proteins

The human pathogen Helicobacter pylori acquires cholesterol from membrane raft domains in eukaryotic cells, commonly known as "lipid rafts." Incorporation of this cholesterol into the H. pylori cell membrane allows the bacterium...

CagA Helicobacter pylori bacterial flotillins Cholesterol Lipid rafts membrane raft domains type IV secretion system Animals Antigens Bacterial Bacterial Adhesion Bacterial Proteins Cell Line Cell Membrane Cholesterol Cytokines Epithelial Cells Eukaryotic Cells Female Gene Expression Regulation Bacterial Helicobacter Infections Helicobacter pylori Host-Pathogen Interactions Humans Interleukin-8 Membrane Microdomains Membrane Proteins Mice Mice Inbred C57BL Mutagenesis Mutation RAW 264.7 Cells Recombinant Proteins Type IV Secretion Systems Virulence

BafA1 bafilomycin A1 EGF epidermal growth factor EGFR epidermal growth factor receptor EM electron microscopy GFP green fluorescent protein KD knockdown LAMP1 lysosomal-associated membrane protein 1 LC3 microtubule-associated protein 1 light chain 3 MVB multivesicular body MYO1C myosin IC PB phosphate buffer PCIP pentachloropseudilin PtdIns(4 5)P2 phosphatidylinositol 4 5-bisphosphate RFP red fluorescent protein RPE retinal pigment epithelium Autophagy Cholesterol Electron microscopy lipid raft lysosome MYO1C Autophagy Cell Line Cell Movement Endocytosis Endosomes Humans Lysosomes Membrane Fusion Membrane Microdomains Myosin Type I Myosins Phagosomes Protein Transport

Cholesterol Regulation Inflammation Ion channel lipid raft Mutagenesis P2X7 Patch clamp Purinergic Receptor Amino Acid Sequence Animals Biotinylation Cell Membrane Cholesterol Cysteine Humans Inflammation Meglumine Membrane Microdomains Mice Molecular Sequence Data Mutagenesis Palmitates Patch-Clamp Techniques Protein Structure Tertiary Receptors Purinergic P2X7 Sequence Homology Amino Acid beta-Cyclodextrins

B Cell Receptor Evi2a immunology integrin Lymphocyte Mass Spectrometry (MS) Proteomics Raftlin SILAC chB6 Animals Avian Proteins B-Lymphocytes Biotin Cell Line Tumor Chickens Integrins Isoantigens Isotope Labeling Membrane Microdomains Microscopy Confocal Microscopy Fluorescence Protein Binding Proteome Proteomics Receptors Antigen B-Cell Staining and Labeling Tyramine

CRAC Cholesterol Lipid microdomains Raft Toll-Like Receptors Amino Acid Sequence Cholesterol Humans Membrane Lipids Membrane Microdomains Models Molecular Molecular Sequence Data Protein Binding Signal Transduction Toll-Like Receptors

Blood Coagulation Blood Platelets Calcimycin extracellular vesicles Filipin Healthy Volunteers Humans Membrane Microdomains Membrane Proteins Phosphatidylserines Platelet Activation Signal Transduction Thrombin beta-Cyclodextrins

Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb....

Age Factors Animals Cerebral Ventricles Gene Expression Regulation Developmental Glial Fibrillary Acidic Protein Green Fluorescent Proteins Homeodomain Proteins Interneurons Kruppel-Like Transcription Factors Membrane Microdomains Mice Neural Stem Cells Neuroglia RNA Untranslated Transcription Factors Transduction Genetic Zinc Finger Protein GLI1