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Embryonic origin and serial homology of gill arches and paired fins in the skate, Leucoraja erinacea
Paired fins are a defining feature of the jawed vertebrate body plan, but their evolutionary origin remains unresolved. Gegenbaur proposed that paired fins evolved as gill arch serial homologues, but this hypothesis is now...
Neuro-mesodermal progenitors (NMPs)
The mammalian embryo's caudal lateral epiblast (CLE) harbours bipotent progenitors, called neural mesodermal progenitors (NMPs), that contribute to the spinal cord and the paraxial mesoderm throughout axial elongation. Here, we...
neuromesodermal progenitors Single cells Transcription Animals Body Patterning Cell Differentiation Cell Lineage Embryo Mammalian Embryonic Stem Cells Female Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Green Fluorescent Proteins In Vitro Techniques Male Mesoderm Mice Neural Stem Cells Pluripotent Stem Cells Spinal Cord Stem Cells Support Vector Machine Transcriptome
Cell cycle regulators control mesoderm specification in human pluripotent stem cells.
Loukia Yiangou, Rodrigo A Grandy, Anna Osnato, Daniel Ortmann, Sanjay Sinha, Ludovic Vallier
Sep 25, 2019
RB transcriptional corepressor 1 (RB1) Cell Cycle cyclin-dependent kinase (CDK) DIFFERENTIATION embryo development Gene Expression Mesoderm Pluripotency signaling Stem Cells tissue regeneration Cell Cycle Cell Differentiation Cell Lineage Cyclin-Dependent Kinases Human Embryonic Stem Cells Humans MAP Kinase Signaling System Mesoderm Protein Kinase Inhibitors Retinoblastoma Binding Proteins Ubiquitin-Protein Ligases
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Christine Cheung, Andreia S Bernardo, Matthew WB Trotter, Roger A Pedersen, Sanjay Sinha
Jan 23, 2018
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental...
The Chick Caudolateral Epiblast Acts as a Permissive Niche for Generating Neuromesodermal Progenitor Behaviours.
Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton.
Gegenbaur's classical hypothesis of jaw-gill arch serial homology is widely cited, but remains unsupported by either palaeontological evidence (for example, a series of fossils reflecting the stepwise transformation of a gill...
Origin and function of the yolk sac in primate embryogenesis.
Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover...
Embryonic origin and serial homology of gill arches and paired fins in the skate, Leucoraja erinacea.
Paired fins are a defining feature of the jawed vertebrate body plan, but their evolutionary origin remains unresolved. Gegenbaur proposed that paired fins evolved as gill arch serial homologues, but this hypothesis is now...
CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines.
Gwladys Zabouo, Anne-Marie Imbert, Jocelyne Jacquemier, Pascal Finetti, Thomas Moreau, Benjamin Esterni, Daniel Birnbaum, François Bertucci, Christian Chabannon
Jun 13, 2011
Adult Aged Aged 80 and over Breast Neoplasms CD146 Antigen Cell Movement Female Flow Cytometry Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing Humans Immunoenzyme Techniques Mesoderm Middle Aged Oligonucleotide Array Sequence Analysis Prognosis RNA Messenger RNA Small Interfering Reverse Transcriptase Polymerase Chain Reaction Tissue Array Analysis Tumor Cells Cultured Young Adult
Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.
Sandra D Castillo, Elena Tzouanacou, May Zaw-Thin, Inma M Berenjeno, Victoria ER Parker, Iñigo Chivite, Maria Milà-Guasch, Wayne Pearce, Isabelle Solomon, Ana Angulo-Urarte, Ana M Figueiredo, Robert E Dewhurst, Rachel G Knox, Graeme R Clark, Cheryl L Scudamore, Adam Badar, Tammy L Kalber, Julie Foster, Daniel J Stuckey, Anna L David, Wayne A Phillips, Mark F Lythgoe, Valerie Wilson, Robert K Semple, Neil J Sebire, Veronica A Kinsler, Mariona Graupera, Bart Vanhaesebroeck
Mar 10, 2016
Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq.
Fabienne Lescroart, Xiaonan Wang, Xionghui Lin, Benjamin Swedlund, Souhir Gargouri, Adriana Sànchez-Dànes, Victoria Moignard, Christine Dubois, Catherine Paulissen, Sarah Kinston, Berthold Göttgens, Cédric Blanpain
Mar 20, 2018
Mouse heart development arises from Mesp1-expressing cardiovascular progenitors (CPs) that are specified during gastrulation. The molecular processes that control early regional and lineage segregation of CPs have been unclear....
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.
Constanze M Hammerle, Ionel Sandovici, Gemma V Brierley, Nicola M Smith, Warren E Zimmer, Ilona Zvetkova, Haydn M Prosser, Yoichi Sekita, Brian YH Lam, Marcella Ma, Wendy N Cooper, Antonio Vidal-Puig, Susan E Ozanne, Gema Medina-Gómez, Miguel Constância
Aug 24, 2020
Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos.
Tissues undergoing morphogenesis impose mechanical effects on one another. How developmental programs adapt to or take advantage of these effects remains poorly explored. Here, using a combination of live imaging, modeling, and...
cell motility Cell Polarity Convergence Coupling elongation Feedback Mechanical forces neural tube (NT) notochord (NC) presomitic mesoderm (PSM) Animals Biomechanical Phenomena Body Patterning Cell Movement Cell Polarity Cell Tracking Chick Embryo Computer Simulation Embryo Nonmammalian Mesoderm Organogenesis Quail
Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo.
Claudio Araya, Marcel Tawk, Gemma C Girdler, Marta Costa, Carlos Carmona-Fontaine, Jonathan DW Clarke
Mar 01, 2021
BACKGROUND: Morphogenesis of the zebrafish neural tube requires the coordinated movement of many cells in both time and space. A good example of this is the movement of the cells in the zebrafish neural plate as they converge...
Steering cell migration by alternating blebs and actin-rich protrusions.
Alba Diz-Muñoz, Pawel Romanczuk, Weimiao Yu, Martin Bergert, Kenzo Ivanovitch, Guillaume Salbreux, Carl-Philipp Heisenberg, Ewa K Paluch
Sep 05, 2019
Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo.
Collective cell migration is essential for morphogenesis, tissue remodelling and cancer invasion. In vivo, groups of cells move in an orchestrated way through tissues. This movement involves mechanical as well as molecular...
Fetal Ossification and Staining in the Chick Embryo
Felix E. Karpinski, Jr.
Jan 01, 0001
This 32 page thesis examines fetal ossification and staining in the chick embryo, including development, incubation, formation of the mesoderm and skeleton and methods for removal and fixation.
Published by: Ursinus College
The zebrafish presomitic mesoderm elongates through compaction-extension.
In vertebrate embryos the presomitic mesoderm becomes progressively segmented into somites at the anterior end while extending along the anterior-posterior axis. A commonly adopted model to explain how this tissue elongates is...
A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation.
Cara B Eldridge, Finian J Allen, Alastair Crisp, Rodrigo A Grandy, Ludovic Vallier, Julian E Sale
Sep 23, 2020
The ability of human induced pluripotent stem cells (hiPSCs) to differentiate in vitro to each of the three germ layer lineages has made them an important model of early human development and a tool for tissue engineering....
Inherent mosaicism and extensive mutation of human placentas.
Tim HH Coorens, Thomas RW Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D Young, Raheleh Rahbari, Neil Sebire, Peter J Campbell, D Stephen Charnock-Jones, Gordon CS Smith, Sam Behjati
Feb 24, 2021
Mesoderm-derived PDGFRA<sup>+</sup> cells regulate the emergence of hematopoietic stem cells in the dorsal aorta.
Vashe Chandrakanthan, Prunella Rorimpandey, Fabio Zanini, Diego Chacon, Jake Olivier, Swapna Joshi, Young Chan Kang, Kathy Knezevic, Yizhou Huang, Qiao Qiao, Rema A Oliver, Ashwin Unnikrishnan, Daniel R Carter, Brendan Lee, Chris Brownlee, Carl Power, Robert Brink, Simon Mendez-Ferrer, Grigori Enikolopov, William Walsh, Berthold Göttgens, Samir Taoudi, Dominik Beck, John E Pimanda
Sep 02, 2022
Published by: Nature cell biology
Creating cellular diversity through transcription factor competition.
Berthold Göttgens
Apr 22, 2015
Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro
Resolving early mesoderm diversification through single-cell expression profiling.
Antonio Scialdone, Yosuke Tanaka, Wajid Jawaid, Victoria Moignard, Nicola K Wilson, Iain C Macaulay, John C Marioni, Berthold Göttgens
Jul 07, 2016
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