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Results: 26
Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion.
Jahyun Koo, Sung Bong Kim, Yeon Sik Choi, Zhaoqian Xie, Amay J Bandodkar, Jawad Khalifeh, Ying Yan, Hojun Kim, Maryam Kherad Pezhouh, Karen Doty, Geumbee Lee, Yu-Yu Chen, Seung Min Lee, Dominic D'Andrea, Kimin Jung, KunHyuck Lee, Kan Li, Seongbin Jo, Heling Wang, Jae-Hwan Kim, Jeonghyun Kim, Sung-Geun Choi, Woo Jin Jang, Yong Suk Oh, Inkyu Park, Sung Soo Kwak, Ji-Hyeon Park, Doosun Hong, Xue Feng, Chi-Hwan Lee, Anthony Banks, Cecilia Leal, Hyuck Mo Lee, Yonggang Huang, Colin K Franz, Wilson Z Ray, Matthew MacEwan, Seung-Kyun Kang, John A Rogers
Sep 10, 2020
Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We...
'Striking the Right Balance' in Targeting PPARgamma in the Metabolic Syndrome
Mark Gurnell
Oct 03, 2017
Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
B Lo, ADE Swafford, KA Shafer-Weaver, LF Jerome, L Rakhlin, DR Mathern, CA Callahan, P Jiang, LJ Davison, HE Stevens, CL Lucas, J White, R von Borstel, JA Todd, MJ Lenardo
Feb 21, 2012
Clinical Research Prevention Autoimmune Disease Diabetes 4.2 Evaluation of markers and technologies 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis Metabolic and endocrine Animals Autoantibodies Diabetes mellitus Type 1 Disease Progression Electrochemistry Female Humans Insulin Antibodies Insulin-Secreting Cells Luminescent Measurements Mice Mice Inbred NOD ROC Curve Radioligand Assay Reproducibility of Results Sensitivity and Specificity
Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial).
Stuart Little, Thomas Chadwick, Pratik Choudhary, Cath Brennand, Julia Stickland, Shalleen Barendse, Tolulope Olateju, Lalantha Leelarathna, Emma Walkinshaw, Horng K Tan, Sally M Marshall, Reena M Thomas, Simon Heller, Mark Evans, David Kerr, Daniel Flanagan, Jane Speight, James Am Shaw
Jan 25, 2013
Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people
Francis M Finucane, Jessica Horton, Lisa R Purslow, David B Savage, Soren Brage, Hervé Besson, Kenneth Horton, Ema De Lucia Rolfe, Alison Sleigh, Stephen J Sharp, Helen J Martin, Avan Aihie Sayer, Cyrus Cooper, Ulf Ekelund, Simon J Griffin, Nicholas J Wareham
Jun 16, 2011
1103 Clinical Sciences 1117 Public Health and Health Services Clinical Clinical Medicine and Science aging Cardiovascular Clinical Research obesity Nutrition Prevention Clinical Trials and Supportive Activities Metabolic and endocrine 6.7 Physical 3.1 Primary prevention interventions to modify behaviours or promote well-being
Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse.
Lee D Roberts, David G Hassall, Deborah A Winegar, John N Haselden, Andrew W Nicholls, Julian L Griffin
Jun 17, 2011
BACKGROUND: The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear receptor superfamily. The PPAR family consists of three members: PPARalpha, PPARgamma, and...
Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals.
Francis M Finucane, Stephen J Sharp, Mensud Hatunic, Alison Sleigh, Ema De Lucia Rolfe, Avan Aihie Sayer, Cyrus Cooper, Simon J Griffin, David B Savage, Nicholas J Wareham
Oct 03, 2017
Important mitochondrial proteins in human omental adipose tissue show reduced expression in obesity.
Peter W Lindinger, Martine Christe, Alex N Eberle, Beatrice Kern, Ralph Peterli, Thomas Peters, Kamburapola JI Jayawardene, Ian M Fearnley, John E Walker
Aug 09, 2017
Obesity is associated with impaired mitochondrial function. This study compares mitochondrial protein expression in omental fat in obese and non-obese humans. Omental adipose tissue was obtained by surgical biopsy, adipocytes...
A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia.
Prevention Schizophrenia Mental Health Biomedical Imaging Brain Disorders obesity Clinical Research Serious Mental Illness Nutrition 2.3 Psychological social and economic factors 2.1 Biological and endogenous factors 2 Aetiology Mental Health Metabolic and endocrine Cardiovascular stroke Oral and gastrointestinal 3 Good Health and Well Being
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Body fat distribution is a heritable risk factor for a range of adverse health consequences, including hyperlipidemia and type 2 diabetes. To identify protein-coding variants associated with body fat distribution, assessed by...
Clinical Research Nutrition Biotechnology Human Genome Prevention Genetics obesity 2.1 Biological and endogenous factors 2 Aetiology Metabolic and endocrine Cardiovascular Animals Body Fat Distribution Body Mass Index Case-Control Studies Drosophila Exome Female Gene Frequency Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Homeostasis Humans Lipids Male Proteins Risk Factors Waist-Hip Ratio
A Metadata description of the data in "A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.".
BACKGROUND: Metabolomics is a rapidly developing functional genomic tool that has a wide range of applications in diverse fields in biology and medicine. However, unlike transcriptomics and proteomics there is currently no...
A BAD portion of glucose can be good for inflamed beta cells.
Christian Frezza
Jul 28, 2020
Exposure to high glucose under inflammatory conditions is detrimental to insulin secreting beta cells in the pancreas. Fu and colleagues, describe a metabolic axis that reduces the production of the danger molecule nitric oxide...
Extracellular vesicles released by steatotic hepatocytes alter adipocyte metabolism
JE Mleczko, F Royo, I Samuelson, M Clos‐Garcia, C Williams, D Cabrera, M Azparren‐Angulo, E Gonzalez, C Garcia‐Vallicrosa, S Carobbio, S Rodriguez‐Cuenca, M Azkargorta, S Liempd, F Elortza, A Vidal‐Puig, S Mora, JM Falcon‐Perez
Mar 15, 2022
Abstract: The composition of extracellular vesicles (EVs) is altered in many pathological conditions, and their molecular content provides essential information on features of parent cells and mechanisms of crosstalk between...
Does adiposity mediate the relationship between physical activity and biological risk factors in youth?
BACKGROUND/OBJECTIVES: To model the association between accumulating 60 daily minutes of moderate-to-vigorous physical activity and a composite score of biological risk factors into a direct and an indirect effect, using...
Exploring ways to respond to rising obesity and diabetes in the Caribbean using a system dynamics model.
Leonor Guariguata, Leandro Garcia, Natasha Sobers, Trevor S Ferguson, James Woodcock, T Alafia Samuels, Cornelia Guell, Nigel Unwin
May 19, 2022
Diabetes and obesity present a high and increasing burden of disease in the Caribbean that have failed to respond to prevention policies and interventions. These conditions are the result of a complex system of drivers and...
An investigation of patterns of children's sedentary and vigorous physical activity throughout the week.
Rebekah M Steele, Esther Mf van Sluijs, Stephen J Sharp, Jill R Landsbaugh, Ulf Ekelund, Simon J Griffin
Jun 16, 2011
1117 Public Health and Health Services Public Health Cardiovascular Pediatric Clinical Research obesity Prevention Clinical Trials and Supportive Activities Oral and gastrointestinal Cardiovascular stroke Metabolic and endocrine Cancer 3.1 Primary prevention interventions to modify behaviours or promote well-being
Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2 : C48R
N Ramanathan, M Ahmed, E Raffan, CL Stewart, S O'Rahilly, RK Semple, H Raef, JJ Rochford
Feb 05, 2020
Loss-of-function mutations in AGPAT2, encoding 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2), produce congenital generalised lipodystrophy (CGL). We screened the AGPAT2 gene in two siblings who presented with...
Wolfram syndrome
Wolfram Syndrome (WS) is an ultra-rare, progressive neurodegenerative disease characterized by early-onset diabetes mellitus and irreversible loss of vision, secondary to optic nerve degeneration. Visual loss in WS is...
Neuroarthropathy in diabetes
Charcot neuroarthropathy is a rare but serious complication of diabetes, causing progressive destruction of the bones and joints of the foot leading to deformity, altered biomechanics and an increased risk of ulceration....
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