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Impact of circulating microRNA test (miRNA-371a-3p) on appropriateness of treatment and cost outcomes in patients with Stage I non-seminomatous germ cell tumours.
Aditya Bagrodia, Anna Savelyeva, John T Lafin, Ryan W Speir, Gregory T Chesnut, Anne Lindsay Frazier, Solomon L Woldu, Vitaly Margulis, Matthew J Murray, James F Amatruda, Yair Lotan
Nov 09, 2020
OBJECTIVES: To determine whether utilisation of a serum microRNA (miRNA) test could improve treatment appropriateness and cost-effectiveness for patients with Stage I non-seminomatous germ cell tumours (NSGCTs). PATIENTS AND...
Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.
Edith L Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne J Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, Marian DiFiglia, Neil Aronin
Sep 20, 2018
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse models have shown that artificial miRNAs can reduce mutant...
AAV Huntington's disease RNAi large animal models Animals Animals Genetically Modified Dependovirus Disease Models Animal Electrolytes Genetic Vectors Genome Viral Humans Huntingtin Protein Huntington Disease Immunoassay Injections Kidney Liver MicroRNAs Microglia Mutant Proteins Neostriatum Neurons RNA Messenger Sheep
Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment.
Alexandra Bezler, Fabian Braukmann, Sean M West, Arthur Duplan, Raffaella Conconi, Frédéric Schütz, Pierre Gönczy, Fabio Piano, Kristin Gunsalus, Eric A Miska, Laurent Keller
Feb 15, 2019
A Multi-institutional Pooled Analysis Demonstrates That Circulating miR-371a-3p Alone is Sufficient for Testicular Malignant Germ Cell Tumor Diagnosis.
Jin Piao, John T Lafin, Cinzia G Scarpini, Michelle M Nuño, Isabella Syring, Klaus-Peter Dieckmann, Gazanfer Belge, Jörg Ellinger, James F Amatruda, Aditya Bagrodia, Nicholas Coleman, Mark D Krailo, A Lindsay Frazier, Matthew J Murray
Sep 01, 2021
MiRNA-Related SNPs and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus
Matthew F Buas, Lynn Onstad, David M Levine, Harvey A Risch, Wong-Ho Chow, Geoffrey Liu, Rebecca C Fitzgerald, Leslie Bernstein, Weimin Ye, Nigel C Bird, Yvonne Romero, Alan G Casson, Douglas A Corley, Nicholas J Shaheen, Anna H Wu, Marilie D Gammon, Brian J Reid, Laura J Hardie, Ulrike Peters, David C Whiteman, Thomas L Vaughan
May 09, 2016
Adenocarcinoma Aged Barrett Esophagus Case-Control Studies Esophageal Neoplasms esophagus Female Gastroesophageal Reflux Gene Expression Regulation Genetic Loci Genome-Wide Association Study Humans Male MicroRNAs Middle Aged obesity Polymorphism Single Nucleotide Risk Factors Sex Factors Smoking White People
Cheryl QE Lee, Lucy Gardner, Margherita Turco, Nancy Zhao, Matthew J Murray, Nicholas Coleman, Janet Rossant, Myriam Hemberger, Ashley Moffett
Jan 14, 2016
Biomarkers Cells Cultured Chromosomes Human Pair 19 DNA Methylation DNA-Binding Proteins Female Fibroblast Growth Factors Histocompatibility Antigens Class I Human Embryonic Stem Cells Humans MicroRNAs Pregnancy Pregnancy Trimester First Promoter Regions Genetic Proto-Oncogene Proteins c-ets Pyrimidines Terminology as Topic Transcription Factors Trophoblasts
Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle
Jette Bork-Jensen, Camilla Scheele, Daniel V Christophersen, Emma Nilsson, Martin Friedrichsen, Denise S Fernandez-Twinn, Louise G Grunnet, Thomas Litman, Kim Holmstrøm, Birgitte Vind, Kurt Højlund, Henning Beck-Nielsen, Jørgen Wojtaszewski, Susan E Ozanne, Bente K Pedersen, Pernille Poulsen, Allan Vaag
Mar 19, 2015
Extent, causes, and consequences of small RNA expression variation in human adipose tissue.
Leopold Parts, Åsa K Hedman, Sarah Keildson, Andrew J Knights, Cei Abreu-Goodger, Martijn van de Bunt, José Afonso Guerra-Assunção, Nenad Bartonicek, Stijn van Dongen, Reedik Mägi, James Nisbet, Amy Barrett, Mattias Rantalainen, Alexandra C Nica, Michael A Quail, Kerrin S Small, Daniel Glass, Anton J Enright, John Winn, MuTHER Consortium, Panos Deloukas, Emmanouil T Dermitzakis, Mark I McCarthy, Timothy D Spector, Richard Durbin, Cecilia M Lindgren
Jan 18, 2018
Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population....
Animals Blood Glucose Body Fat Distribution Body Mass Index Fasting Female Gene Expression Regulation genetic variation Genome-Wide Association Study Genotype High-Throughput Nucleotide Sequencing Humans Insulin MicroRNAs Middle Aged Polymorphism Single Nucleotide RNA Messenger RNA Small Nucleolar RNA Small Untranslated Subcutaneous Fat
Exploring regulatory networks of miR-96 in the developing inner ear.
Morag A Lewis, Annalisa Buniello, Jennifer M Hilton, Fei Zhu, William I Zhang, Stephanie Evans, Stijn van Dongen, Anton J Enright, Karen P Steel
Jan 22, 2018
Mutations in the microRNA Mir96 cause deafness in mice and humans. In the diminuendo mouse, which carries a single base pair change in the seed region of miR-96, the sensory hair cells crucial for hearing fail to develop fully...
Detecting microRNA binding and siRNA off-target effects from expression data.
Sylamer is a method for detecting microRNA target and small interfering RNA off-target signals in 3' untranslated regions from a ranked gene list, sorted from upregulated to downregulated, after a microRNA perturbation or RNA...
Overexpression of the Cytokine BAFF and Autoimmunity Risk
M Steri, V Orrù, ML Idda, M Pitzalis, M Pala, I Zara, C Sidore, V Faà, M Floris, M Deiana, I Asunis, E Porcu, A Mulas, MG Piras, M Lobina, S Lai, M Marongiu, V Serra, M Marongiu, G Sole, F Busonero, A Maschio, R Cusano, G Cuccuru, F Deidda, F Poddie, G Farina, M Dei, F Virdis, S Olla, MA Satta, M Pani, A Delitala, E Cocco, J Frau, G Coghe, L Lorefice, G Fenu, P Ferrigno, M Ban, N Barizzone, M Leone, FR Guerini, M Piga, D Firinu, I Kockum, I Lima Bomfim, T Olsson, L Alfredsson, A Suarez, PE Carreira, MJ Castillo-Palma, JH Marcus, M Congia, A Angius, M Melis, A Gonzalez, ME Alarcón Riquelme, BM da Silva, M Marchini, MG Danieli, S Del Giacco, A Mathieu, A Pani, SB Montgomery, G Rosati, J Hillert, S Sawcer, S D'Alfonso, JA Todd, J Novembre, GR Abecasis, MB Whalen, MG Marrosu, A Meloni, S Sanna, M Gorospe, D Schlessinger, E Fiorillo, M Zoledziewska, F Cucca
Jun 27, 2017
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy.
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Dec 10, 2019
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival....
C. elegans Autophagy Biochemistry chemical biology Genetics Genomics human cells mammalian cells microRNA protein aggregation 3' Untranslated Regions Animals Autophagy Base Sequence Caenorhabditis elegans Caenorhabditis elegans Proteins GTPase-Activating Proteins HeLa Cells Humans Huntingtin Protein Interferon-beta Mice MicroRNAs Mutant Proteins Peptides Protein Aggregates RNA Messenger rab GTP-Binding Proteins rab7 GTP-Binding Proteins
Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse.
Elena Piccinin, Maria Arconzo, Giusi Graziano, Michele Vacca, Claudia Peres, Elena Bellafante, Gaetano Villani, Antonio Moschetta
Feb 03, 2020
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players...
Decreased expression of miR-29 family associated with autoimmune myasthenia gravis.
Mélanie A Cron, Cloé A Payet, Odessa-Maud Fayet, Solène Maillard, Frédérique Truffault, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Adrian Liston, Rozen Le Panse
Dec 14, 2020
BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease mainly mediated by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction. The thymus is the effector organ, and its removal...
BAFF DICER Experimental autoimmune myasthenia gravis Interferon-β Th17 Cells Thymic epithelial cells Thymus MicroRNAs Adolescent Adult Animals Autoantibodies Cells Cultured Female Gene Expression Humans Male Mice Mice Inbred C57BL Mice Knockout MicroRNAs myasthenia gravis myasthenia gravis Autoimmune Experimental Receptors Cholinergic Thymus Gland Young Adult
In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.
Qianxin Wu, Quentin RV Ferry, Toni A Baeumler, Yale S Michaels, Dimitrios M Vitsios, Omer Habib, Roland Arnold, Xiaowei Jiang, Stefano Maio, Bruno R Steinkraus, Marta Tapia, Paolo Piazza, Ni Xu, Georg A Holländer, Thomas A Milne, Jin-Soo Kim, Anton J Enright, Andrew R Bassett, Tudor A Fulga
May 01, 2018
RNA regulatory elements (RREs) are an important yet relatively under-explored facet of gene regulation. Deciphering the prevalence and functional impact of this post-transcriptional control layer requires technologies for...
MiR-221 influences effector functions and actin cytoskeleton in mast cells.
Ramon J Mayoral, Lorenzo Deho, Nicole Rusca, Nenad Bartonicek, Harpreet Kaur Saini, Anton J Enright, Silvia Monticelli
Jan 23, 2018
Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost...
3T3 Cells Actin Cytoskeleton Actins Animals Base Sequence Bone Marrow Cells Cell Adhesion Cell Degranulation Cell Differentiation Cell Movement Cell Proliferation Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation FIBROBLASTS Gene Knockdown Techniques Lentivirus Mast Cells Mice Mice Inbred C57BL MicroRNAs Molecular Sequence Data Oligonucleotide Array Sequence Analysis Up-Regulation
Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.
Martin M Fabani, Cei Abreu-Goodger, Donna Williams, Paul A Lyons, Adrian G Torres, Kenneth GC Smith, Anton J Enright, Michael J Gait, Elena Vigorito
Nov 16, 2017
MicroRNAs (miRNAs) play an important role in diverse physiological processes and are potential therapeutic agents. Synthetic oligonucleotides (ONs) of different chemistries have proven successful for blocking miRNA expression....
miRBase
Sam Griffiths-Jones, Russell J Grocock, Stijn van Dongen, Alex Bateman, Anton J Enright
Nov 16, 2017
The miRBase database aims to provide integrated interfaces to comprehensive microRNA sequence data, annotation and predicted gene targets. miRBase takes over functionality from the microRNA Registry and fulfils three main roles...
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.
Marilyn B Renfree, Anthony T Papenfuss, Janine E Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D Waters, Elizabeth A Pharo, Geoff Shaw, Emily SW Wong, Christophe M Lefèvre, Kevin R Nicholas, Yoko Kuroki, Matthew J Wakefield, Kyall R Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W Nicholas, Danielle Hickford, Hongshi Yu, Kirsty R Short, Hannah V Siddle, Stephen R Frankenberg, Keng Yih Chew, Brandon R Menzies, Jessica M Stringer, Shunsuke Suzuki, Timothy A Hore, Margaret L Delbridge, Hardip R Patel, Amir Mohammadi, Nanette Y Schneider, Yanqiu Hu, William O'Hara, Shafagh Al Nadaf, Chen Wu, Zhi-Ping Feng, Benjamin G Cocks, Jianghui Wang, Paul Flicek, Stephen MJ Searle, Susan Fairley, Kathryn Beal, Javier Herrero, Dawn M Carone, Yutaka Suzuki, Sumio Sugano, Atsushi Toyoda, Yoshiyuki Sakaki, Shinji Kondo, Yuichiro Nishida, Shoji Tatsumoto, Ion Mandiou, Arthur Hsu, Kaighin A McColl, Benjamin Lansdell, George Weinstock, Elizabeth Kuczek, Annette McGrath, Peter Wilson, Artem Men, Mehlika Hazar-Rethinam, Allison Hall, John Davis, David Wood, Sarah Williams, Yogi Sundaravadanam, Donna M Muzny, Shalini N Jhangiani, Lora R Lewis, Margaret B Morgan, Geoffrey O Okwuonu, San Juana Ruiz, Jireh Santibanez, Lynne Nazareth, Andrew Cree, Gerald Fowler, Christie L Kovar, Huyen H Dinh, Vandita Joshi, Chyn Jing, Fremiet Lara, Rebecca Thornton, Lei Chen, Jixin Deng, Yue Liu, Joshua Y Shen, Xing-Zhi Song, Janette Edson, Carmen Troon, Daniel Thomas, Amber Stephens, Lankesha Yapa, Tanya Levchenko, Richard A Gibbs, Desmond W Cooper, Terence P Speed, Asao Fujiyama, Jennifer AM Graves, Rachel J O'Neill, Andrew J Pask, Susan M Forrest, Kim C Worley
Mar 30, 2012
BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced....
Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance.
ATM DNA damage response Cancer cancer therapy ionising radiation miR-34a miRNA p53 protein phosphatase protein phosphatase 1γ 3' Untranslated Regions Algorithms Blotting Western Cell Line Tumor DNA Damage Gene Expression Regulation Neoplastic Humans MicroRNAs Phosphorylation Protein Phosphatase 1 RADIATION Ionizing Tumor Suppressor Protein p53
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