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Results: 168
Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight.
Christine B Jensen, Malgorzata S Martin-Gronert, Heidi Storgaard, Sten Madsbad, Allan Vaag, Susan E Ozanne
Aug 12, 2020
BACKGROUND: Low birth weight (LBW) is associated with increased future risk of insulin resistance and type 2 diabetes mellitus. The underlying molecular mechanisms remain poorly understood. We have previously shown that young...
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
Steven D Mason, Richard A Howlett, Matthew J Kim, I Mark Olfert, Michael C Hogan, Wayne McNulty, Reed P Hickey, Peter D Wagner, C Ronald Kahn, Frank J Giordano, Randall S Johnson
Mar 13, 2020
The physiological flux of oxygen is extreme in exercising skeletal muscle. Hypoxia is thus a critical parameter in muscle function, influencing production of ATP, utilization of energy-producing substrates, and manufacture of...
Adenosine Triphosphate Alleles Animals creatine kinase Crosses Genetic Gene Deletion Gene Expression Regulation Genotype Glucose Glycogen Glycolysis Hematocrit Hemoglobins Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Lactic Acid Male Mice Mice Inbred C57BL Mice Knockout Microscopy Electron Muscle Skeletal Oxygen Physical Conditioning Animal Physical Exertion Polymerase Chain Reaction Promoter Regions Genetic Reverse Transcriptase Polymerase Chain Reaction
4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension.
Benjamin J Dunmore, Xudong Yang, Alexi Crosby, Stephen Moore, Lu Long, Christopher Huang, Mark Southwood, Eric D Austin, Amer Rana, Paul D Upton, Nicholas W Morrell
Apr 06, 2020
Mutations in the gene encoding BMPR2 (bone morphogenetic protein type 2 receptor) are the major cause of heritable pulmonary arterial hypertension (PAH). Point mutations in the BMPR2 ligand-binding domain involving cysteine...
Hypertension Mutation pulmonary Treatment Animals Bone Morphogenetic Protein Receptors Type II Cell Proliferation Cells Cultured Cysteine Humans Mice Muscle Smooth Vascular Mutation Myocytes Smooth Muscle Organophosphorus Compounds pulmonary arterial hypertension Pulmonary Artery Signal Transduction Vascular Remodeling
A Mediterranean Diet Is Positively Associated with Bone and Muscle Health in a Non-Mediterranean Region in 25,450 Men and Women from EPIC-Norfolk
Research on Mediterranean diet (MD) adherence and musculoskeletal health is limited. The current study determined if adherence to the alternative MD score (aMED) and MD score (MDS), quantified from 7-d food diaries, was...
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Michael E Reschen, Da Lin, Anil Chalisey, Elizabeth J Soilleux, Christopher A O'Callaghan
Dec 17, 2018
BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with...
Atherosclerosis Expression quantitative trait locus (eQTL) Functional genomics genetic disease Genetic polymorphism Genomics Low-density lipoprotein (LDL) Myocardial Infarction Oxidized low density lipoprotein (oxLDL) PHACTR1 Adult Aged Alleles Atherosclerosis Coronary Artery Disease Coronary Vessels Endothelial Cells Gene Expression Regulation Gene-Environment Interaction Genotype Humans Inflammation Lipopolysaccharides MACROPHAGES Microfilament Proteins Middle Aged Muscle Smooth Vascular Polymorphism Single Nucleotide Tumor Necrosis Factor-alpha Young Adult
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.
Pete J Cox, Tom Kirk, Tom Ashmore, Kristof Willerton, Rhys Evans, Alan Smith, Andrew J Murray, Brianna Stubbs, James West, Stewart W McLure, M Todd King, Michael S Dodd, Cameron Holloway, Stefan Neubauer, Scott Drawer, Richard L Veech, Julian L Griffin, Kieran Clarke
Oct 03, 2018
Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering oxidative fuel selection. Often overlooked for its metabolic potential, ketosis is poorly understood outside of starvation or diabetic...
Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy.
Rita Horvath, John P Kemp, Helen AL Tuppen, Gavin Hudson, Anders Oldfors, Suely KN Marie, Ali-Reza Moslemi, Serenella Servidei, Elisabeth Holme, Sara Shanske, Gittan Kollberg, Parul Jayakar, Angela Pyle, Harold M Marks, Elke Holinski-Feder, Mena Scavina, Maggie C Walter, Jorida Coku, Andrea Günther-Scholz, Paul M Smith, Robert McFarland, Zofia MA Chrzanowska-Lightowlers, Robert N Lightowlers, Michio Hirano, Hanns Lochmüller, Robert W Taylor, Patrick F Chinnery, Mar Tulinius, Salvatore DiMauro
Mar 07, 2019
Childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions that have a fatal outcome. However, a puzzling infantile disorder, long known as 'benign cytochrome c oxidase deficiency...
Neuromuscular performance of paretic versus non-paretic plantar flexors after stroke.
Marius Steiro Fimland, Per Marius R Moen, Tessa Hill, Tor Ivar Gjellesvik, Tom Tørhaug, Jan Helgerud, Jan Hoff
Jun 18, 2018
The objective of this study was to compare the neuromuscular function of the paretic and non-paretic plantar flexors (i.e. soleus, gastrocnemius medialis, lateralis) in chronic stroke patients. It was hypothesized that the...
Fatal infantile mitochondrial encephalomyopathy, hypertrophic cardiomyopathy and optic atrophy associated with a homozygous OPA1 mutation.
Ronen Spiegel, Ann Saada, Padraig J Flannery, Florence Burté, Devorah Soiferman, Morad Khayat, Verónica Eisner, Eugene Vladovski, Robert W Taylor, Laurence A Bindoff, Avraham Shaag, Hanna Mandel, Ora Schuler-Furman, Stavit A Shalev, Orly Elpeleg, Patrick Yu-Wai-Man
Jun 28, 2018
BACKGROUND: Infantile-onset encephalopathy and hypertrophic cardiomyopathy caused by mitochondrial oxidative phosphorylation defects are genetically heterogeneous with defects involving both the mitochondrial and nuclear...
Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.
Daniel J Fazakerley, Annabel Y Minard, James R Krycer, Kristen C Thomas, Jacqueline Stöckli, Dylan J Harney, James G Burchfield, Ghassan J Maghzal, Stuart T Caldwell, Richard C Hartley, Roland Stocker, Michael P Murphy, David E James
Jun 28, 2018
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in insulin resistance. However, disentangling the individual roles of these processes in insulin resistance has been difficult because they...
MITOCHONDRIAL DYSFUNCTION adipocyte Adipose Tissue Hydrogen Peroxide Insulin Insulin Resistance Mitochondria Muscle Oxidative Stress superoxide ion 3T3-L1 Cells Adenylate Kinase Adipocytes Animals Electron Transport Glucose Glucose Transporter Type 4 Herbicides Hydrogen Peroxide Insulin Insulin Resistance Male Mice Mice Inbred C57BL Mitochondria Myoblasts Oxidative Phosphorylation Oxygen Consumption Paraquat Peroxiredoxins Protein Isoforms Superoxides
A Mediterranean Diet Is Positively Associated with Bone and Muscle Health in a Non-Mediterranean Region in 25,450 Men and Women from EPIC-Norfolk.
Research on Mediterranean diet (MD) adherence and musculoskeletal health is limited. The current study determined if adherence to the alternative MD score (aMED) and MD score (MDS), quantified from 7-d food diaries, was...
Three-dimensional polygonal muscle modelling and line of action estimation in living and extinct taxa.
Oliver E Demuth, Ashleigh LA Wiseman, Julia van Beesel, Heinrich Mallison, John R Hutchinson
Apr 02, 2022
Biomechanical models and simulations of musculoskeletal function rely on accurate muscle parameters, such as muscle masses and lines of action, to estimate force production potential and moment arms. These parameters are often...
Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models.
Joel Chappell, Jennifer L Harman, Vagheesh M Narasimhan, Haixiang Yu, Kirsty Foote, Benjamin D Simons, Martin R Bennett, Helle F Jørgensen
Nov 22, 2016
Atherosclerosis lineage-tracing MACROPHAGES Neointima Phenotype vascular diseases vascular smooth muscle Animals Atherosclerosis Cell Proliferation Disease Models Animal Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Mice Transgenic Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Vascular System Injuries
Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle
Jette Bork-Jensen, Camilla Scheele, Daniel V Christophersen, Emma Nilsson, Martin Friedrichsen, Denise S Fernandez-Twinn, Louise G Grunnet, Thomas Litman, Kim Holmstrøm, Birgitte Vind, Kurt Højlund, Henning Beck-Nielsen, Jørgen Wojtaszewski, Susan E Ozanne, Bente K Pedersen, Pernille Poulsen, Allan Vaag
Mar 19, 2015
Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal.
Yataro Daigo, Ichiro Takayama, Bruce AJ Ponder, Carlos Caldas, Sean M Ward, Kenton M Sanders, Masayuki A Fujino
Jun 16, 2011
AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles
The Danish Diabetes Academy supports JJ with a Visiting Professorship.
Injury incidence, severity and type across the menstrual cycle in female footballers
Purpose The aim of the study was to assess the influence of menstrual cycle phase on injury incidence, severity, and type in elite female professional footballers over three seasons. Methods Time-loss injuries and menstrual...
SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human.
Vietxuan Phan, Dan Cox, Silvia Cipriani, Sally Spendiff, Stephan Buchkremer, Emily O'Connor, Rita Horvath, Hans Hilmar Goebel, Denisa Hathazi, Hanns Lochmüller, Tatjana Straka, Rüdiger Rudolf, Joachim Weis, Andreas Roos
Dec 20, 2018
BACKGROUND: Marinesco-Sjögren Syndrome (MSS) is a rare neuromuscular condition caused by recessive mutations in the SIL1 gene resulting in the absence of functional SIL1 protein, a co-chaperone for the major ER chaperone, BiP....
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Christine Cheung, Andreia S Bernardo, Matthew WB Trotter, Roger A Pedersen, Sanjay Sinha
Jan 23, 2018
Heterogeneity of embryological origins is a hallmark of vascular smooth muscle cells (SMCs) and may influence the development of vascular disease. Differentiation of human pluripotent stem cells (hPSCs) into developmental...
Metastatic adenocarcinoma with osseous metaplasia in the pelvic limb musculature of a cat.
An adult female neutered domestic shorthair cat of unknown age presented with a six-month history of progressive hind limb stiffness. Clinical examination revealed firm, painful enlargement of the quadriceps femoris muscles...
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