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Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties...

Rotavirus type I interferon type III interferon NSP1 IRF-1 IRF-3 IRF-7 NF-κB

Microglia-mediated neuroinflammatory responses are inevitable and important pathological processes in several kinds of disorder of the central nervous system (CNS). Therefore, alleviating activated microglia-induced inflammatory...

BHDPC CREB NF-κB PKA Microglia Neuroinflammation

Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development...

IGHV usage MALT lymphoma NF-κB TNFAIP3 mutation Biomarkers Tumor DNA Mutational Analysis Eye Neoplasms Gene Rearrangement Gene Silencing Genes Immunoglobulin Heavy Chain Genetic Predisposition to Disease Humans Immunoglobulin Variable Region Lymphoma B-Cell Marginal Zone Mutation Neoplasms Adnexal and Skin Appendage Phenotype Tumor Necrosis Factor alpha-Induced Protein 3

autism Brain Inflammation NF-κB Amniotic Fluid Animals Antigens surface Autism spectrum disorder Autoantibodies Body Fluids Brain Brain Chemistry Chemokines Cytokines Female Glutamic Acid HLA Antigens Haplorhini Humans Immunity Maternally-Acquired Inflammation Inflammation Mediators Lipopolysaccharides Maternal-Fetal Exchange Mice Nerve Tissue Proteins Neuroglia Neuroimaging Pregnancy Pregnancy Complications Infectious prenatal exposure delayed effects Signal Transduction

NF-κB Autism spectrum condition Brain Inflammation orbitofrontal cortex pH

microbiology SARS-CoV-2 innate immunity Nsp6 Orf6 Orf8 IRF3 NF-κB JAK-STAT

Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and...

IL-6 NF-κB TPRG1L Gene regulation human cytomegalovirus lncRNA transcriptomics Cells Cultured Cytokines Cytomegalovirus FIBROBLASTS Humans Interleukin-6 NF-kappa B RNA Long Noncoding RNA Viral

Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs...

Enhancer RNA ERK and p38 LIPOPOLYSACCHARIDE long non-coding RNA monocyte NF-κB

ADAP Adaptors GRB-2 NF-κB VAV-1 Adaptor Proteins Signal Transducing Animals CD28 Antigens Humans Jurkat Cells Mice Mice Knockout NF-kappa B Receptors Antigen T-Cell Signal Transduction T-Lymphocytes

NF-κB ectoderm abnormalities Genetics immunodeficiency Skin

NF-κB SASP Endothelium immune surveillance Liver Senescence Animals Cellular Senescence Endothelial Cells Endothelium Mice NF-kappa B Phenotype

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic, induces an unbalanced immune response in the host. For instance, the production of...

IRF3 JAK-STAT NF-κB Nsp6 Orf6 Orf8 SARS-CoV-2 innate immunity

Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties...

IRF-1 IRF-3 IRF-7 NF-κB NSP1 Rotavirus type I interferon type III interferon Animals Epithelial Cells HEK293 Cells Humans Interferon Regulatory Factor-1 Interferon Type I Interferons Intestines Rotavirus Viral Nonstructural Proteins

Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and...

Cellular and Infection Microbiology human cytomegalovirus lncRNA IL-6 Gene regulation transcriptomics TPRG1L NF-κB

Optineurin (OPTN) is a multifunctional protein involved in autophagy and secretion, as well as nuclear factor κB (NF-κB) and IRF3 signalling, and OPTN mutations are associated with several human diseases. Here, we show that, in...

ATG9A BioID functional proteomics IFN LUBAC Linear ubiquitin NF-κB OPTN TBK1 Cell Cycle Proteins Cytokines Glaucoma Open-Angle Humans Membrane Transport Proteins NF-kappa B Protein Transport Signal Transduction Transcription Factor TFIIIA

BTB-Kelch E3 ligase NF-κB cullin-3 importins protein A55 vaccinia virus Animals BTB-POZ Domain Cell Line Cullin Proteins Female HEK293 Cells Humans Immune Evasion Immunity Innate Karyopherins Kelch Repeat Mice Mice Inbred C57BL NF-kappa B Poxviridae Signal Transduction T-Lymphocytes Ubiquitin-Protein Ligases Vaccinia vaccinia virus Viral Proteins Virulence Virus Replication alpha Karyopherins

Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs...

Enhancer RNA ERK and p38 LIPOPOLYSACCHARIDE long non-coding RNA monocyte NF-κB

The host immune response and virus-encoded immune evasion proteins pose constant, mutual selective pressure on each other. Virally encoded immune evasion proteins also indicate which host pathways must be inhibited to allow for...

DNA virus IIV-6 IMD NF-κB Host-Pathogen Interactions immunomodulators Viral immune evasion Animals Drosophila Proteins Drosophila melanogaster Host-Pathogen Interactions Immunity Innate Iridovirus Toll-Like Receptors Transcription Factors Virus Replication

MALT lymphoma NF-κB genetic abnormalities immunological drive