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Results: 33
Oxygen-Enhanced and Dynamic Contrast-Enhanced Optoacoustic Tomography Provide Surrogate Biomarkers of Tumor Vascular Function, Hypoxia, and Necrosis.
Michal R Tomaszewski, Marcel Gehrung, James Joseph, Isabel Quiros-Gonzalez, Jonathan A Disselhorst, Sarah E Bohndiek
Sep 29, 2018
Measuring the functional status of tumor vasculature, including blood flow fluctuations and changes in oxygenation, is important in cancer staging and therapy monitoring. Current clinically approved imaging modalities suffer...
Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis.
Acrylamides Apoptosis Carcinoma Renal Cell Epithelial Cells Gene Expression Regulation Neoplastic Humans In Situ Nick-End Labeling Kidney Neoplasms Kidney Tubules Necrosis Organ Culture Techniques Quinazolinones RNA Messenger Receptor-Interacting Protein Serine-Threonine Kinases Receptors Tumor Necrosis Factor Type I Signal Transduction Sulfonamides Tumor Necrosis Factor-alpha Up-Regulation
Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging.
Adam J Brown, Zhongzhao Teng, Patrick A Calvert, Nikil K Rajani, Orla Hennessy, Nitesh Nerlekar, Daniel R Obaid, Charis Costopoulos, Yuan Huang, Stephen P Hoole, Martin Goddard, Nick EJ West, Jonathan H Gillard, Martin R Bennett
Jun 09, 2016
Atherosclerosis Autopsy Coronary Disease Myocardial Infarction Prospective Studies Acute Coronary Syndrome Aged Angina Stable Coronary Artery Disease Coronary Vessels Disease-Free Survival Female Fibrosis Humans Kaplan-Meier Estimate Male Middle Aged Necrosis Percutaneous Coronary Intervention Plaque Atherosclerotic Predictive Value of Tests Proportional Hazards Models Prospective Studies Risk Factors Rupture Spontaneous Severity of Illness Index Stress Mechanical Time Factors Treatment Outcome Ultrasonography Interventional Vascular Calcification
Impact of Non-obstructive left main disease on the progression of coronary artery disease
Jonathan R Weir-McCall, Philipp Blanke, Stephanie L Sellers, Amir A Ahmadi, Daniele Andreini, Matthew J Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Eun Ju Chun, Edoardo Conte, Ilan Gottlieb, Martin Hadamitzky, Yong Jin Kim, Byoung Kwon Lee, Sang-Eun Lee, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Sanghoon Shin, Ji Min Sung, Peter Stone, Habib Samady, Renu Virmani, Jagat Narula, Daniel S Berman, Leslee J Shaw, Jeroen J Bax, Fay Y Lin, James K Min, Hyuk-Jae Chang, Jonathon A Leipsic
Sep 30, 2019
BACKGROUND: The aim of the study is examine the impact of non-obstructive (<50%stenosis) left main (LM) disease on the natural history of coronary artery disease using serial coronary computed tomography angiography (CTA)....
Coronary computed tomography angiography Left main coronary artery disease Natural History Aged Chi-Square Distribution Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Coronary Stenosis Coronary Vessels Disease Progression Female Fibrosis Humans Linear Models Male Middle Aged Multivariate Analysis Necrosis Plaque Atherosclerotic Predictive Value of Tests prevalence Registries Risk Assessment Risk Factors Severity of Illness Index Time Factors Vascular Calcification
Biomarkers for site-specific response to neoadjuvant chemotherapy in epithelial ovarian cancer
Jessica M Winfield, Jennifer C Wakefield, James D Brenton, Khalid AbdulJabbar, Antonella Savio, Susan Freeman, Erika Pace, Kerryn Lutchman-Singh, Katherine M Vroobel, Yinyin Yuan, Susana Banerjee, Nuria Porta, Shan E Ahmed Raza, Nandita M deSouza
Mar 16, 2021
TNF induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport
Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to...
Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2
Calpain Caspase Endothelial Cell Inflammation interleukin 1 (IL-1) interleukin-1 receptor-2 necrosis (necrotic death) Transplantation vascular biology Vascular smooth muscle cells Allografts Calpain Caspase 1 Graft Rejection Human Umbilical Vein Endothelial Cells Humans interleukin-1 Interleukin-1alpha Necrosis Proteolysis Receptors Interleukin-1 Type II Tumor Necrosis Factor-alpha
TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish infected with Mycobacterium marinum or...
BAX Calcium ER ROS TNF-mediated necrosis Calcium Channel Blockers macrophage Mitochondrion ryanodine receptors Tuberculosis Animals Apoptosis Calcium Endoplasmic Reticulum Humans Lysosomes MACROPHAGES Membrane potential Mitochondrial Mitochondria Mycobacterium Infections Nontuberculous Mycobacterium marinum Mycobacterium tuberculosis Necrosis Reactive Oxygen Species THP-1 Cells Tuberculosis Tumor Necrosis Factor-alpha Zebrafish
Ionic immune suppression within the tumour microenvironment limits T cell effector function.
Robert Eil, Suman K Vodnala, David Clever, Christopher A Klebanoff, Madhusudhanan Sukumar, Jenny H Pan, Douglas C Palmer, Alena Gros, Tori N Yamamoto, Shashank J Patel, Geoffrey C Guittard, Zhiya Yu, Valentina Carbonaro, Klaus Okkenhaug, David S Schrump, W Marston Linehan, Rahul Roychoudhuri, Nicholas P Restifo
Jun 27, 2018
Tumours progress despite being infiltrated by tumour-specific effector T cells. Tumours contain areas of cellular necrosis, which are associated with poor survival in a variety of cancers. Here, we show that necrosis releases...
Animals cations Monovalent Humans Immune Tolerance Immunotherapy Kv1.3 Potassium Channel Male Melanoma Membrane Potentials Mice Necrosis Potassium Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell Signal Transduction Survival Analysis T-Lymphocytes TOR Serine-Threonine Kinases Tumor Escape Tumor Microenvironment
Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.
Acute kidney injury (AKI) remains a major problem in critically unwell children and young adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a significant proportion of these cases and...
The Dendritic Cell Receptor DNGR-1 Promotes the Development of Atherosclerosis in Mice.
Yacine Haddad, Charlotte Lahoute, Marc Clément, Ludivine Laurans, Sarvenaz Metghalchi, Lynda Zeboudj, Andreas Giraud, Xavier Loyer, Marie Vandestienne, Julien Wain-Hobson, Bruno Esposito, Stephane Potteaux, Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat, Soraya Taleb
Jun 21, 2018
RATIONALE: Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between...
Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.
Jack J Miller, Angus Z Lau, Per Mose Nielsen, Giles McMullen-Klein, Andrew J Lewis, Nichlas Riise Jespersen, Vicky Ball, Ferdia A Gallagher, Carolyn A Carr, Christoffer Laustsen, Hans Erik Bøtker, Damian J Tyler, Marie A Schroeder
Feb 11, 2019
OBJECTIVES: The aim of this study was to determine if hyperpolarized [1,4-13C2]malate imaging could measure cardiomyocyte necrosis after myocardial infarction (MI). BACKGROUND: MI is defined by an acute burst of cellular...
cardiac MRI Energy Metabolism hyperpolarized MR Magnetic Resonance Spectroscopy Necrosis Animals Carbon Isotopes Carbon-13 Magnetic Resonance Spectroscopy Contrast Media Energy Metabolism Fumarates Isolated Heart Preparation Magnetic Resonance Imaging Cine Malates Male Molecular Imaging Myocardial Infarction Myocytes Cardiac Necrosis Predictive Value of Tests Rats Wistar
Molecular mechanisms of cell death
Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V Antonov, Eli Arama, Eric H Baehrecke, Nickolai A Barlev, Nicolas G Bazan, Francesca Bernassola, Mathieu JM Bertrand, Katiuscia Bianchi, Mikhail V Blagosklonny, Klas Blomgren, Christoph Borner, Patricia Boya, Catherine Brenner, Michelangelo Campanella, Eleonora Candi, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Navdeep S Chandel, Emily H Cheng, Jerry E Chipuk, John A Cidlowski, Aaron Ciechanover, Gerald M Cohen, Marcus Conrad, Juan R Cubillos-Ruiz, Peter E Czabotar, Vincenzo D'Angiolella, Ted M Dawson, Valina L Dawson, Vincenzo De Laurenzi, Ruggero De Maria, Klaus-Michael Debatin, Ralph J DeBerardinis, Mohanish Deshmukh, Nicola Di Daniele, Francesco Di Virgilio, Vishva M Dixit, Scott J Dixon, Colin S Duckett, Brian D Dynlacht, Wafik S El-Deiry, John W Elrod, Gian Maria Fimia, Simone Fulda, Ana J García-Sáez, Abhishek D Garg, Carmen Garrido, Evripidis Gavathiotis, Pierre Golstein, Eyal Gottlieb, Douglas R Green, Lloyd A Greene, Hinrich Gronemeyer, Atan Gross, Gyorgy Hajnoczky, J Marie Hardwick, Isaac S Harris, Michael O Hengartner, Claudio Hetz, Hidenori Ichijo, Marja Jäättelä, Bertrand Joseph, Philipp J Jost, Philippe P Juin, William J Kaiser, Michael Karin, Thomas Kaufmann, Oliver Kepp, Adi Kimchi, Richard N Kitsis, Daniel J Klionsky, Richard A Knight, Sharad Kumar, Sam W Lee, John J Lemasters, Beth Levine, Andreas Linkermann, Stuart A Lipton, Richard A Lockshin, Carlos López-Otín, Scott W Lowe, Tom Luedde, Enrico Lugli, Marion MacFarlane, Frank Madeo, Michal Malewicz, Walter Malorni, Gwenola Manic, Jean-Christophe Marine, Seamus J Martin, Jean-Claude Martinou, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Sonia Melino, Edward A Miao, Jeffery D Molkentin, Ute M Moll, Cristina Muñoz-Pinedo, Shigekazu Nagata, Gabriel Nuñez, Andrew Oberst, Moshe Oren, Michael Overholtzer, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M Penninger, David M Pereira, Shazib Pervaiz, Marcus E Peter, Mauro Piacentini, Paolo Pinton, Jochen HM Prehn, Hamsa Puthalakath, Gabriel A Rabinovich, Markus Rehm, Rosario Rizzuto, Cecilia Mp Rodrigues, David C Rubinsztein, Thomas Rudel, Kevin M Ryan, Emre Sayan, Luca Scorrano, Feng Shao, Yufang Shi, John Silke, Hans-Uwe Simon, Antonella Sistigu, Brent R Stockwell, Andreas Strasser, Gyorgy Szabadkai, Stephen Wg Tait, Daolin Tang, Nektarios Tavernarakis, Andrew Thorburn, Yoshihide Tsujimoto, Boris Turk, Tom Vanden Berghe, Peter Vandenabeele, Matthew G Vander Heiden, Andreas Villunger, Herbert W Virgin, Karen H Vousden, Domagoj Vucic, Erwin F Wagner, Henning Walczak, David Wallach, Ying Wang, James A Wells, Will Wood, Junying Yuan, Zahra Zakeri, Boris Zhivotovsky, Laurence Zitvogel, Gerry Melino, Guido Kroemer
Oct 10, 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field...
Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment.
Antonio J Pagán, Chao-Tsung Yang, James Cameron, Laura E Swaim, Felix Ellett, Graham J Lieschke, Lalita Ramakrishnan
Jun 26, 2015
A nebulised antitumour necrosis factor receptor-1 domain antibody in patients at risk of postoperative lung injury
James Ryan, Andrew I Bayliffe, Daniel F McAuley, Joyce Yeung, David R Thickett, Phillip A Howells, Ciara O'Donnell, Arlette M Vassallo, Tracey J Wright, Elizabeth McKie, Kelly Hardes, Charlotte Summers, Martin O Shields, William Powley, Robert Wilson, Aili L Lazaar, Andrew Fowler, Gavin D Perkins
Nov 20, 2020
BACKGROUND: Tumour necrosis factor receptor 1 (TNFR1) signalling mediates the cell death and inflammatory effects of TNF-α. OBJECTIVE: The current clinical trial investigated the effects of a nebulised TNFR1 antagonist...
A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac
Hannah Wong, Stephanie Byrne, Roberta Rasotto, Randi Drees, Angela Taylor, Simon L Priestnall, Chiara Leo
Nov 23, 2021
Canine apocrine gland anal sac adenocarcinoma (AGASAC) is a malignant tumour with variable clinical progression. The objective of this study was to use robust multivariate models, based on models employed in human medical...
Dynamic biomarker and imaging changes from a phase II study of pre- and post-surgical sunitinib.
Sarah J Welsh, Nicola Thompson, Anne Warren, Andrew N Priest, Tristan Barrett, Stephan Ursprung, Ferdia A Gallagher, Fulvio Zaccagna, Grant D Stewart, Kate M Fife, Athena Matakidou, Andrea J Machin, Wendi Qian, Victoria Ingleson, Jean Mullin, Antony CP Riddick, James N Armitage, Stephen Connolly, Timothy GQ Eisen
Nov 03, 2021
Inhibition of snake venom induced sterile inflammation and PLA2 activity by Titanium dioxide Nanoparticles in experimental animals.
Shubhro Chakrabartty, Md Iqbal Alam, Saumya Bhagat, Aftab Alam, Neha Dhyani, Gausal A Khan, M Sarwar Alam
Oct 29, 2020
Sterile inflammation (SI) is an essential process in response to snakebite and injury. The venom induced pathophysiological response to sterile inflammation results into many harmful and deleterious effects that ultimately leads...
Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am
Zoltan Szucs, James Joseph, Tim J. Larkin, Bangwen Xie, Sarah E. Bohndiek, Kevin M. Brindle, André A. Neves
Mar 15, 2021
Abstract: Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature...
Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload.
Matthew T Harper
Nov 06, 2017
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.
Natalie Cook, Kristopher K Frese, Tashinga E Bapiro, Michael A Jacobetz, Aarthi Gopinathan, Jodi L Miller, Sudhir S Rao, Tim Demuth, William J Howat, Duncan I Jodrell, David A Tuveson
Sep 03, 2020
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical intervention. Notch pathway antagonism has been shown to prevent pancreatic preneoplasia progression in mouse models, but potential...
Amyloid Precursor Protein Secretases Animals Carcinoma Pancreatic Ductal Cell Line Tumor Cell Proliferation Cyclic S-Oxides Deoxycytidine Drug Synergism Drug Therapy Combination Endothelial Cells Humans Hypoxia Mice Mice Mutant Strains Necrosis Pancreatic Neoplasms Protease Inhibitors Receptors Notch Signal Transduction Thiadiazoles Translational Research Biomedical Gemcitabine
Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8-associated ligand on necrotic glandular epithelial cells.
Des C Jones, Colin RA Hewitt, María R López-Álvarez, Martin Jahnke, Alasdair I Russell, Valeria Radjabova, Alice RZ Trowsdale, John Trowsdale
Jan 13, 2016
Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response.
Marc Clément, Gemma Basatemur, Leanne Masters, Lauren Baker, Patrick Bruneval, Takao Iwawaki, Manfred Kneilling, Sho Yamasaki, Jane Goodall, Ziad Mallat
Nov 14, 2016
Pattern, timing and predictors of recurrence after surgical resection of chromophobe renal cell carcinoma.
Joana B Neves, Leyre Vanaclocha Saiz, Yasmin Abu-Ghanem, Marta Marchetti, My-Anh Tran-Dang, Soha El-Sheikh, Ravi Barod, Christian Beisland, Umberto Capitanio, David Cullen, Tobias Klatte, Börje Ljungberg, Faiz Mumtaz, Prasad Patki, Grant D Stewart, Saeed Dabestani, Maxine GB Tran, Axel Bex, RECUR consortium
Mar 29, 2021
PURPOSE: Currently there are no specific guidelines for the post-operative follow-up of chromophobe renal cell carcinoma (chRCC). We aimed to evaluate the pattern, location and timing of recurrence after surgery for...
Chromophobe renal cell carcinoma follow-up Nephrectomy renal cell carcinoma survival Adult Aged Aged 80 and over Bone Neoplasms Carcinoma Renal Cell Disease-Free Survival Female Humans Kaplan-Meier Estimate Kidney Neoplasms Male Margins of Excision Middle Aged Multivariate Analysis Necrosis Neoplasm Recurrence Local Neoplasm Staging Proportional Hazards Models Risk Factors Young Adult
The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function.
BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) mediates the transcriptional response to hypoxic stress, promoting tumour progression and survival. This study investigated the acute effects of the small-molecule HIF-pathway...
Animals Antineoplastic Agents blood vessels Cell Hypoxia Cell Line Tumor Diffusion Magnetic Resonance Imaging Glucose Glucose Transporter Type 1 Humans Hypoxia-Inducible Factor 1 Isoenzymes Isoquinolines L-Lactate Dehydrogenase Lactate Dehydrogenase 5 Male Mice Necrosis Neoplasms Experimental Proto-Oncogene Proteins c-myc
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