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Rapid and efficient processing of external information by the brain is vital to survival in a highly dynamic environment. The key channel humans use to exchange information is language, but the neural underpinnings of its...

Adult Brain Mapping Female Humans language Magnetoencephalography Male Neocortex Spatio-Temporal Analysis Young Adult

Cholinergic tone is high during wake and rapid eye movement sleep and lower during slow wave sleep (SWS). Nevertheless, the low tone of acetylcholine during SWS modulates sharp wave ripple incidence in the hippocampus and slow...

Acetylcholine network synchrony population calcium imaging slow wave sleep spontaneous activity Action Potentials Animals Cholinergic Agents Entorhinal Cortex Hippocampus Mice Neocortex

astrocyte brain tumorigenesis gliogenesis intermediate gliogenic progenitors Neocortex Neurofibromin 1 oligodendrocyte radial glial progenitors Animals Astrocytes Biomarkers Carcinogenesis Cell Lineage Mice Inbred C57BL Neocortex Neural Stem Cells Neurofibromin 1 Neurogenesis Neuroglia Oligodendroglia

We believe this is the first study to investigate associations between blood metabolites and neocortical amyloid burden (NAB) in the search for a blood-based biomarker for Alzheimer's disease (AD). Further, we present the first...

Aged Alzheimer Disease Amyloid beta-Peptides Biomarkers Female Humans Male Middle Aged Neocortex

Epidemiological and genetic studies have identified metabolic disorders and inflammation as risk factors for Alzheimer's disease (AD). Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome...

Alzheimer's Disease CFAS Dementia HUMAN BRAIN metaflammasome Aged Aged 80 and over Alzheimer Disease Apolipoproteins E Cohort Studies Diabetes mellitus Type 2 Female Humans I-kappa B Kinase Immunohistochemistry Insulin Receptor Substrate Proteins MAP Kinase Kinase 4 Male Mental Status Schedule Neocortex Phosphorylation Polymorphism Genetic Risk Factors eIF-2 Kinase

Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism patients converge on common genes and pathways. However, direct assessment of specific cell...

Adolescent Autistic Disorder Cell Nucleus Child Child Preschool Female Gene Expression Profiling Gene Expression Regulation Genomics Humans Male Microglia Neocortex Neurons Sequence Analysis RNA Single-Cell Analysis Young Adult

Dementia Neocortex Serum amyloid P component

Humans Brain Mapping Neocortex Magnetic Resonance Imaging Brain Positron-Emission Tomography Neurotransmitter Agents

Slow-wave sleep is characterized by near-synchronous alternation of active Up states and quiescent Down states in the neocortex. Although the cortex itself can maintain these oscillations, the full expression of Up-Down states...

GABAergic interneuron Up-Down states INHIBITION in vivo MOUSE non-specific thalamic nuclei Slow oscillation slow-wave sleep synchronization thalamocortical Animals Evoked Potentials Female Interneurons Male Mice Mice Inbred C57BL Neocortex Receptors GABA-B Sleep Slow-Wave Thalamus

brain evolution cerebellum molecular evolution Neocortex Primates Animals cerebellum evolution Molecular Gene Expression Regulation Developmental Gene Ontology Genetic Loci Haplorhini Neocortex Organ Size Phenotype Phylogeny Regression Analysis Species Specificity

Animals Mice Neocortex Neurogenesis Neuroglia Neurons Otx Transcription Factors Staining and Labeling Stem Cells