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Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N Christie, Shefeeq M Theparambil, Sean M Davidson, Frank Reimann, Stefan Trapp, Derek M Yellon, Alexander V Gourine
Jan 28, 2022
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments...
Brain capillaries Brain arterioles cerebral blood flow Glucagon-like peptide-1 Ischaemic stroke Middle cerebral artery occlusion Neuroprotection Remote ischaemic preconditioning Animals Arterioles Cerebrovascular Circulation Disease Models Animal Glucagon-Like Peptide-1 Receptor Hindlimb Incretins Infarction Middle Cerebral artery Ischemic preconditioning ischemic stroke Male Neuroprotective Agents Peptide Fragments Rats Sprague-Dawley Regional Blood Flow Vasodilation Vasodilator Agents
A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity.
Wei-Li Kuan, Emma Poole, Michael Fletcher, Sharon Karniely, Pam Tyers, Mark Wills, Roger A Barker, John H Sinclair
Nov 16, 2017
Parkinson's disease (PD) is a neurodegenerative disorder that results in the loss of nigrostriatal dopamine neurons. The etiology of this cell loss is unknown, but it involves abnormalities in mitochondrial function. In this...
Animals Cell Death Cell Line Cytomegalovirus Disease Models Animal Dopaminergic Neurons Electron Transport Complex I Enzyme Activation HEK293 Cells Humans Injections Intravenous Male Mitochondria Neuroprotective Agents Neurotoxins Parkinson Disease Peptides RNA transport RNA Untranslated RNA Viral Rats Rats Sprague-Dawley Substantia Nigra
GDNF and Parkinson's Disease
Roger A Barker, Anders Björklund, Don M Gash, Alan Whone, Amber Van Laar, Jeffrey H Kordower, Krystof Bankiewicz, Karl Kieburtz, Mart Saarma, Sigrid Booms, Henri J Huttunen, Adrian P Kells, Massimo S Fiandaca, A Jon Stoessl, David Eidelberg, Howard Federoff, Merja H Voutilainen, David T Dexter, Jamie Eberling, Patrik Brundin, Lyndsey Isaacs, Leah Mursaleen, Eros Bresolin, Camille Carroll, Alasdair Coles, Brian Fiske, Helen Matthews, Codrin Lungu, Richard K Wyse, Simon Stott, Anthony E Lang
Jul 17, 2020
The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor...
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.
Veselina Petrova, Craig S Pearson, Jared Ching, James R Tribble, Andrea G Solano, Yunfei Yang, Fiona M Love, Robert J Watt, Andrew Osborne, Evan Reid, Pete A Williams, Keith R Martin, Herbert M Geller, Richard Eva, James W Fawcett
Sep 22, 2020
Animals Axons Cells Cultured Central Nervous System Endoplasmic Reticulum Endosomes Female Humans Integrins Mice Mice Inbred C57BL Mutation Nerve Regeneration Neurons Neuroprotective Agents Optic Nerve Injuries Phosphorylation Protein Domains Rats Rats Sprague-Dawley Retina Vesicular Transport Proteins
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Farah H Siddiqi, Fiona M Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo JR Fernandes, Andrew Bassett, Eric Karran, Bruce L Miller, Angeleen Fleming, David C Rubinsztein
Mar 13, 2019
Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins...
Animals Animals Genetically Modified Autophagy Cell Line Cerebral Cortex Disease Models Animal Drug Repositioning Embryo Mammalian Embryo Nonmammalian Felodipine Female Humans Induced Pluripotent Stem Cells Male Mice Mice Inbred C57BL Mutation Neurodegenerative Diseases Neurons Neuroprotective Agents Primary Cell Culture Swine Swine Miniature Treatment Outcome Zebrafish ALPHA-SYNUCLEIN
Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease.
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher Jh Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Jan 04, 2022
The most frequent missense mutations in familial Parkinson's disease (PD) occur in the highly conserved LRRK2/PARK8 gene with G2019S mutation. We previously established a fly model of PD carrying the LRRK2-G2019S mutation that...
BMP/Mad D. melanogaster Gastrodia elata Blume Lrrk2 NRF2 Parkinson's Disease Glia MOUSE neuroscience Animals Benzyl Alcohols Butyrates Disease Models Animal Dopaminergic Neurons Drosophila melanogaster Gastrodia Glucosides Locomotion Mice NF-E2-Related Factor 2 Neuroglia Neuroprotection Neuroprotective Agents Parkinson Disease Plant Extracts Signal Transduction
Pharmacological Management of Lewy Body Dementia
Chris Stinton, Ian McKeith, John-Paul Taylor, Louise Lafortune, Eneida Mioshi, Elijah Mak, Victoria Cambridge, James Mason, Alan Thomas, John T O'Brien
Dec 22, 2015
Computational drug repositioning for ischemic stroke
Background: A comprehensive approach to drug repositioning will be required to overcome translational hurdles and identify more neuroprotective drugs. Results & methods: Gene Set Enrichment Analysis was applied to identify...
Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.
Ozayra Sharmin, Ariful Haque Abir, Abdullah Potol, Mahabub Alam, Jewel Banik, AFM Towheedur Rahman, Nuzhat Tarannum, Rasiqh Wadud, Zaki Farhad Habib, Mahbubur Rahman
Jun 10, 2021
Pamoic acid is a potent ligand for G protein Coupled Receptor 35 (GPR35) and exhibits antinociceptive property. GPR35 activation leads to increased energy utilization and the expression of anti-inflammatory genes. However, its...
Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.
Vien Nguyen, Khalida Sabeur, Emin Maltepe, Kurosh Ameri, Omer Bayraktar, David H Rowitch
Nov 29, 2018
The cerebellum undergoes rapid growth during the third trimester and is vulnerable to injury and deficient growth in infants born prematurely. Factors associated with preterm cerebellar hypoplasia include chronic lung disease...
brain development cerebral palsy Glucocorticoid HIF signaling Hypoxia Shh signaling Amino Acids Dicarboxylic Animals Animals Newborn Anti-Inflammatory Agents Basic Helix-Loop-Helix Transcription Factors Calcium-Binding Proteins Cell Proliferation Cells Cultured cerebellum Cyclohexylamines Developmental Disabilities Disease Models Animal Gene Expression Regulation Developmental Glucocorticoids Hedgehog Proteins Hypoxia Brain Mice Mice Inbred C57BL Mice Transgenic Microfilament Proteins Nerve Tissue Proteins Nervous System Malformations Neuroprotective Agents Prednisolone Purkinje Cells Thiophenes Von Hippel-Lindau Tumor Suppressor Protein Zinc Finger Protein GLI1
The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin)
Danuta M Lisiecka, John Suckling, Thomas RE Barnes, Imran B Chaudhry, Paola Dazzan, Nusrat Husain, Peter B Jones, Eileen M Joyce, Stephen M Lawrie, Rachel Upthegrove, Bill Deakin
May 01, 2018
BACKGROUND: Negative symptoms of psychosis do not respond to the traditional therapy with first- or second-generation antipsychotics and are among main causes of a decrease in quality of life observed in individuals suffering...
Clinical Protocols Double-Blind Method Humans Magnetic Resonance Imaging Minocycline Neuroprotective Agents Outcome Assessment Health Care Psychotic Disorders
Published by: Trials
RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.
Amandine Bastide, Diego Peretti, John RP Knight, Stefano Grosso, Ruth V Spriggs, Xavier Pichon, Thomas Sbarrato, Anne Roobol, Jo Roobol, Davide Vito, Martin Bushell, Tobias von der Haar, C Mark Smales, Giovanna R Mallucci, Anne E Willis
Sep 05, 2018
Cooling and hypothermia are profoundly neuroprotective, mediated, at least in part, by the cold shock protein, RBM3. However, the neuroprotective effector proteins induced by RBM3 and the mechanisms by which mRNAs encoding cold...
α-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2.
A new villain in neuronal death.
A newly discovered partnership for glutamate triggers brain toxicity
Susan Jones
Apr 07, 2021
Moving to human trials for argon neuroprotection in neurological injury
Despite the global burden of brain injury, neuroprotective agents remain elusive. There are no clinically effective therapies which reduce mortality or improve long-term cognitive outcome. Ventilation could be an easily...
Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells.
Optic neuropathies such as glaucoma occur when retinal ganglion cells (RGCs) in the eye are injured. Strong evidence suggests mesenchymal stem cells (MSCs) could be a potential therapy to protect RGCs; however, little is known...
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Mark Halliday, Helois Radford, Karlijn AM Zents, Collin Molloy, Julie A Moreno, Nicholas C Verity, Ewan Smith, Catharine A Ortori, David A Barrett, Martin Bushell, Giovanna R Mallucci
Nov 16, 2017
See Mercado and Hetz (doi:10.1093/brain/awx107) for a scientific commentary on this article.Signalling through the PERK/eIF2α-P branch of the unfolded protein response plays a critical role in controlling protein synthesis...
The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin)
Bill Deakin, John Suckling, Thomas RE Barnes, Kelly Byrne, Imran B Chaudhry, Paola Dazzan, Richard J Drake, Annalisa Giordano, Nusrat Husain, Peter B Jones, Eileen Joyce, Emma Knox, Carl Krynicki, Stephen M Lawrie, Shôn Lewis, Danuta M Lisiecka-Ford, Naghmeh Nikkheslat, Carmine M Pariante, Richard Smallman, Andrew Watson, Steven Cr Williams, Rachel Upthegrove, Graham Dunn, BeneMin Study team
Dec 10, 2018
BACKGROUND: The antibiotic minocycline has neuroprotective and anti-inflammatory properties that could prevent or reverse progressive neuropathic changes implicated in recent-onset schizophrenia. In the BeneMin study, we aimed...
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A Moreno, Joern R Steinert, Tim Smith, David Dinsdale, Anne E Willis, Giovanna R Mallucci
Nov 09, 2017
In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity. Reduction in synapse number is a consistent early feature of neurodegenerative...
Repurposing Pomalidomide as a Neuroprotective Drug
Maria Francesca Palmas, Anna Ena, Chiara Burgaletto, Maria Antonietta Casu, Giuseppina Cantarella, Ezio Carboni, Michela Etzi, Alfonso De Simone, Giuliana Fusco, Maria Cristina Cardia, Francesco Lai, Luca Picci, David Tweedie, Michael T Scerba, Valentina Coroneo, Renato Bernardini, Nigel H Greig, Augusta Pisanu, Anna R Carta
May 25, 2022
Marketed drugs for Parkinson's disease (PD) treat disease motor symptoms but are ineffective in stopping or slowing disease progression. In the quest of novel pharmacological approaches that may target disease progression...
ALPHA-SYNUCLEIN cytokine Drug Repositioning immunomodulation Motor impairment Neuroprotection Animals Cytokines Disease Models Animal Disease Progression Drug Repositioning Humans Microglia Neuroprotective Agents Parkinson Disease Rats Substantia Nigra Thalidomide Tumor Necrosis Factor-alpha ALPHA-SYNUCLEIN