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Results: 36
The Grizzly, February 25, 2016
Brian Thomas, Deana Harley, William DiCiurcio, Leighnah L. Perkins, Tingyue Gong, Valerie Osborne, Tyler Arsenault, Briana Keane, Johnny Cope, Hunter Gellman, Bryce Pinkerton
Jan 01, 0001
Students, Faculty Talk About Changes to CIE Community Celebrates Life of Michelle Buck Community Comes Together During Norovirus Outbreak Learning More About Housing International Perspective: Differences Within the...
Ursinus College Collegeville Pennsylvania newspaper CIE Diversity SUN Michelle Buck Norovirus student housing Jon Volkmer Diane Skorina banned books Social Media Jen Wolfe study abroad lacrosse Swimming Basketball Jess Porada Alyssa Polimeni cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Modelling norovirus transmission and vaccination.
deterministic Markov model mathematical model Norovirus ODEs vaccine Adolescent Adult Aged Caliciviridae Infections Child Child Preschool Cost-Benefit Analysis Female Gastroenteritis Germany Humans Infant Infant Newborn Male Markov Chains Middle Aged Models Theoretical Monte Carlo Method Norovirus Vaccination Viral Vaccines Young Adult
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Liliane Chung, Dalan Bailey, Eoin N Leen, Edward P Emmott, Yasmin Chaudhry, Lisa O Roberts, Stephen Curry, Nicolas Locker, Ian G Goodfellow
Jul 09, 2014
Eukaryotic Translation Initiation Factor 4E (eIF4E) Norovirus Plus-stranded RNA Virus Translation Translation Initiation Factor VPg Virus eIF4G Base Sequence Chromatography Affinity DNA Primers Eukaryotic Initiation Factor-4G Genome Viral Norovirus Polymerase Chain Reaction Protein Binding Protein Biosynthesis Proteomics Viral Proteins
Detection of Hepatitis E Virus Antibodies in Dogs in the United Kingdom.
Aoife McElroy, Rintaro Hiraide, Nick Bexfield, Hamid Jalal, Joe Brownlie, Ian Goodfellow, Sarah L Caddy
Jun 10, 2015
Functions of the 5' and 3' ends of calicivirus genomes.
Caliciviruses Norovirus RNA secondary structures RNA–protein interactions 3' Untranslated Regions 5' Untranslated Regions Animals Caliciviridae Conserved Sequence Genome Viral Host-Pathogen Interactions Humans Models Biological Nucleic Acid Conformation Promoter Regions Genetic RNA Viral Transcription Genetic Virus Replication
Polyprotein processing and intermolecular interactions within the viral replication complex spatially and temporally control norovirus protease activity.
Edward Emmott, Alexis de Rougemont, Myra Hosmillo, Jia Lu, Timothy Fitzmaurice, Jürgen Haas, Ian Goodfellow
Feb 07, 2019
Norovirus infections are a major cause of acute viral gastroenteritis and a significant burden on global human health. A vital process for norovirus replication is the processing of the nonstructural polyprotein by a viral...
Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.
Harriet V Mears, Edward Emmott, Yasmin Chaudhry, Myra Hosmillo, Ian G Goodfellow, Trevor R Sweeney
Nov 15, 2019
Background: Norovirus, also known as the winter vomiting bug, is the predominant cause of non-bacterial gastroenteritis worldwide. Disease control is predicated on a robust innate immune response during the early stages of...
Published by: Wellcome Open Res
Molecular chaperone Hsp90 is a therapeutic target for noroviruses.
Surender Vashist, Luis Urena, Mariam B Gonzalez-Hernandez, Jayoung Choi, Alexis de Rougemont, Joana Rocha-Pereira, Johan Neyts, Seungmin Hwang, Christiane E Wobus, Ian Goodfellow
Jun 13, 2018
UNLABELLED: Human noroviruses (HuNoV) are a significant cause of acute gastroenteritis in the developed world, and yet our understanding of the molecular pathways involved in norovirus replication and pathogenesis has been...
Capturing the systemic immune signature of a norovirus infection
Antony J Cutler, Joao Oliveira, Ricardo C Ferreira, Ben Challis, Neil M Walker, Sarah Caddy, Jia Lu, Helen E Stevens, Deborah J Smyth, Marcin L Pekalski, Jane Kennet, Kara MD Hunter, Ian Goodfellow, Linda S Wicker, John A Todd, Frank Waldron-Lynch
Sep 05, 2018
BACKGROUND: The infection of a participant with norovirus during the adaptive study of interleukin-2 dose on regulatory T cells in type 1 diabetes (DILT1D) allowed a detailed insight into the cellular and cytokine immune...
Targeting macrophage- and intestinal epithelial cell-specific microRNAs against norovirus restricts replication in vivo.
Until recently, our understanding of the cellular tropism of human norovirus (HuNoV), a major cause of viral gastroenteritis, has been limited. Immune cells and intestinal epithelial cells (IECs) have been proposed as targets of...
A robust human norovirus replication model in zebrafish larvae.
Jana Van Dycke, Annelii Ny, Nádia Conceição-Neto, Jan Maes, Myra Hosmillo, Arno Cuvry, Ian Goodfellow, Tatiane C Nogueira, Erik Verbeken, Jelle Matthijnssens, Peter de Witte, Johan Neyts, Joana Rocha-Pereira
Oct 28, 2019
Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models has significantly hindered the understanding of...
Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.
Hanne Dubois, Frederic Sorgeloos, Soroush T Sarvestani, Liesbet Martens, Yvan Saeys, Jason M Mackenzie, Mohamed Lamkanfi, Geert van Loo, Ian Goodfellow, Andy Wullaert
Mar 25, 2019
Animals Apoptosis Regulatory Proteins Caliciviridae Infections Cells Cultured Gastrointestinal Tract Inflammasomes Interleukin-1beta Intracellular Signaling Peptides and Proteins MACROPHAGES Mice Mice Inbred C57BL Mice Knockout NLR Family Pyrin Domain-Containing 3 Protein Norovirus Phosphate-Binding Proteins pyroptosis STAT1 Transcription Factor
Identification of amino acids within norovirus polymerase involved in RNA binding and viral replication.
Kang Rok Han, Bader Y Alhatlani, Sunyoung Cho, Ji-Hye Lee, Myra Hosmillo, Ian G Goodfellow, Kyung Hyun Kim, Jai Myung Yang
Aug 03, 2017
Evidence for human norovirus infection of dogs in the United kingdom.
Sarah L Caddy, Alexis de Rougemont, Edward Emmott, Laila El-Attar, Judy A Mitchell, Michael Hollinshead, Gael Belliot, Joe Brownlie, Jacques le Pendu, Ian Goodfellow
Jun 03, 2015
Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus
Karla D Passalacqua, Jia Lu, Ian Goodfellow, Abimbola O Kolawole, Jacob R Arche, Robert J Maddox, Kelly E Carnahan, Mary XD O’Riordan, Christiane E Wobus
Mar 14, 2019
calicivirus carbon metabolism Glycolysis noroviruses Oxidative Phosphorylation pentose phosphate pathway Animals Caco-2 Cells Caliciviridae Infections Glycolysis Host-Pathogen Interactions Humans MACROPHAGES Metabolomics Mice Norovirus Oxidative Phosphorylation pentose phosphate pathway RAW 264.7 Cells Virus Replication
Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro.
DNA Methylation epigenetic reprogramming human norovirus replicon interferon lambda receptor microarrays Cell Line Cell Line Tumor Down-Regulation Epigenesis Genetic Humans Interferons Norovirus Real-Time Polymerase Chain Reaction Receptors Interferon Tissue Array Analysis Virus Replication Interferon Lambda
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M Willcocks, Roy Parker, Ian G Goodfellow, Alessia Ruggieri, Nicolas Locker
Jan 31, 2020
Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress...
Animals Caliciviridae Infections Cell Line Cytoplasmic Granules DNA Helicases Eukaryotic Initiation Factor-2 Humans Mice Mice Inbred C57BL Norovirus Poly-ADP-Ribose Binding Proteins Protein Biosynthesis RAW 264.7 Cells RNA RNA Helicases RNA Recognition Motif Proteins Signal Transduction Virus Replication
Recovery of genetically defined murine norovirus in tissue culture by using a fowlpox virus expressing T7 RNA polymerase.
Despite the significant disease burden caused by human norovirus infection, an efficient tissue-culture system for these viruses remains elusive. Murine norovirus (MNV) is an ideal surrogate for the study of norovirus biology...
TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing
Jakub Luptak, Donna L Mallery, Aminu S Jahun, Anna Albecka, Dean Clift, Osaid Ather, Greg Slodkowicz, Ian Goodfellow, Leo C James
Jul 24, 2022
TRIM7 catalyzes the ubiquitination of multiple substrates with unrelated biological functions. This cross-reactivity is at odds with the specificity usually displayed by enzymes, including ubiquitin ligases. Here we show that...
Published by: MDPI
The Grizzly, February 18, 2016
Brian Thomas, Deana Harley, Courtney A DuChene, Valerie Osborne, Jay Farrell, Johnny Myers, Hunter Gellman, Tyler Arsenault, Madelyn Franklin, Erin McKinney, Bryce Pinkerton
Jan 01, 0001
Norovirus Sickens 200+ Ursinus Remembers Dr. Richard King Rainbow Resource Center Comes Back Mid-term Recharge Created to Help Students Through Slump Renowned Author Visits Campus Quaker Group Formalizing Activities, Meals...
Ursinus College Collegeville Pennsylvania newspaper Norovirus Richard King Rainbow Resource Center Jan Levengood Dan-el Padilla Peralta Quakerism Daan Slaats Wismer dining hall Matt Knowles Basketball wrestling cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors.
Lucy Thorne, Angela Nalwoga, Alexander J Mentzer, Alexis de Rougemont, Myra Hosmillo, Emily Webb, Margaret Nampiija, Allan Muhwezi, Tommy Carstensen, Deepti Gurdasani, Adrian V Hill, Manj S Sandhu, Alison Elliott, Ian Goodfellow
Jul 25, 2018
BACKGROUND: Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity, and immunity in sub-Saharan African children. We investigated HuNoV...
Antibodies Viral Blood Group Antigens Caliciviridae Infections Child Preschool Cross-Sectional Studies Demography Disease Susceptibility Enzyme-Linked Immunosorbent Assay Female Fucosyltransferases Gastroenteritis genetic variation Genotype Humans Infant Infant Newborn Longitudinal Studies Male Norovirus Polymorphism Single Nucleotide Pregnancy Risk Factors Seroepidemiologic Studies Socioeconomic Factors Uganda
The murine norovirus core subgenomic RNA promoter consists of a stable stem-loop that can direct accurate initiation of RNA synthesis.
Muhammad Amir Yunus, Xiaoyan Lin, Dalan Bailey, Ioannis Karakasiliotis, Yasmin Chaudhry, Surender Vashist, Guo Zhang, Lucy Thorne, C Cheng Kao, Ian Goodfellow
Oct 22, 2014
Interferon responses to norovirus infections
Human noroviruses (HuNoVs) are increasingly becoming the main cause of transmissible gastroenteritis worldwide, with hundreds of thousands of deaths recorded annually. Yet, decades after their discovery, there is still no...
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