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Results: 6
Channel nuclear pore complex subunits are required for transposon silencing in Drosophila.
Marzia Munafò, Victoria R Lawless, Alessandro Passera, Serena MacMillan, Susanne Bornelöv, Irmgard U Haussmann, Matthias Soller, Gregory J Hannon, Benjamin Czech
Jul 05, 2021
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective...
D. melanogaster Cell Biology Chromosomes Gene Expression nuclear pore complex nucleoporins piRNAs piwi-interacting RNAs RNA export transposon silencing Animals Animals Genetically Modified Cell Line DNA Transposable Elements Drosophila Proteins Drosophila melanogaster Female Gene Expression Regulation Nuclear Pore Nuclear Pore Complex Proteins Nucleocytoplasmic Transport Proteins Ovary RNA Interference RNA Long Noncoding RNA Small Interfering
P(I) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5).
Emily V Wong, Wenxiang Cao, Judit Vörös, Monique Merchant, Yorgo Modis, David D Hackney, Ben Montpetit, Enrique M De La Cruz
Aug 09, 2017
The DDX6-4E-T interaction mediates translational repression and P-body assembly.
Anastasiia Kamenska, Clare Simpson, Caroline Vindry, Helen Broomhead, Marianne Bénard, Michèle Ernoult-Lange, Benjamin P Lee, Lorna W Harries, Dominique Weil, Nancy Standart
Jul 12, 2016
Amino Acid Sequence Binding Sites DEAD-box RNA Helicases DNA-Binding Proteins Eukaryotic Initiation Factor-4E Eukaryotic Initiation Factor-4G Gene Expression Regulation HEK293 Cells HeLa Cells Humans Nucleocytoplasmic Transport Proteins Protein Binding Protein Biosynthesis Protein Interaction Maps Proto-Oncogene Proteins RNA Small Interfering RNA-Binding Proteins Transcription Factors
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Guillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S Bauer, Jennifer E Dodd, Monika A Myszczynska, Sarah M Alam, Pierre Garneret, Jayanth S Chandran, Evangelia Karyka, Matthew J Stopford, Emma F Smith, Janine Kirby, Kathrin Meyer, Brian K Kaspar, Adrian M Isaacs, Sherif F El-Khamisy, Kurt J De Vos, Ke Ning, Mimoun Azzouz, Alexander J Whitworth, Pamela J Shaw
Dec 17, 2018
Adult Aged Amyotrophic Lateral Sclerosis Animals Astrocytes C9orf72 Protein Cell Line Coculture Techniques Disease Models Animal Drosophila Female frontotemporal dementia Humans Male Mice Middle Aged Nuclear Proteins Nucleocytoplasmic Transport Proteins RNA-Binding Proteins Rats Serine-Arginine Splicing Factors Transcription Factors
P(I) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5).
Emily V Wong, Wenxiang Cao, Judit Vörös, Monique Merchant, Yorgo Modis, David D Hackney, Ben Montpetit, Enrique M De La Cruz
Mar 03, 2016
Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.
Emma Kneuss, Marzia Munafò, Evelyn L Eastwood, Undine-Sophie Deumer, Jonathan B Preall, Gregory J Hannon, Benjamin Czech
Aug 13, 2019
The PIWI-interacting RNA (piRNA) pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilization. In Drosophila ovaries, most piRNAs originate from...
PIWI proteins RNA export nuclear export factor piRNA clusters transposon control Active Transport Cell Nucleus Animals DNA Transposable Elements Drosophila Drosophila Proteins Intracellular Signaling Peptides and Proteins Nucleocytoplasmic Transport Proteins RNA Precursors RNA Small Interfering RNA-Binding Proteins