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Dual role of the integrated stress response in medulloblastoma tumorigenesis.
Sarrabeth Stone, Yeung Ho, Xiting Li, Stephanie Jamison, Heather P Harding, David Ron, Wensheng Lin
Aug 16, 2017
In response to endoplasmic reticulum (ER) stress, activation of pancreatic ER kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating translation initiation factor 2α...
ER stress GADD34 integrated stress response Medulloblastoma Tumorigenesis Animals Apoptosis Cell Line Tumor Cell Proliferation Cell Transformation Neoplastic Cerebellar Neoplasms Endoplasmic reticulum stress Enzyme Activation Eukaryotic Initiation Factor-2 Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Homozygote Humans Medulloblastoma Mice Inbred C57BL Mice Knockout Mutation Neoplastic Stem Cells Neovascularization Pathologic Patched-1 Receptor Phenotype Phosphorylation Protein Phosphatase 1 Signal Transduction Time Factors eIF-2 Kinase
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Miller Huang, Jignesh Tailor, Qiqi Zhen, Aaron H Gillmor, Matthew L Miller, Holger Weishaupt, Justin Chen, Tina Zheng, Emily K Nash, Lauren K McHenry, Zhenyi An, Fubaiyang Ye, Yasuhiro Takashima, James Clarke, Harold Ayetey, Florence MG Cavalli, Betty Luu, Branden S Moriarity, Shirin Ilkhanizadeh, Lukas Chavez, Chunying Yu, Kathreena M Kurian, Thierry Magnaldo, Nicolas Sevenet, Philipp Koch, Steven M Pollard, Peter Dirks, Michael P Snyder, David A Largaespada, Yoon Jae Cho, Joanna J Phillips, Fredrik J Swartling, A Sorana Morrissy, Marcel Kool, Stefan M Pfister, Michael D Taylor, Austin Smith, William A Weiss
Jul 25, 2019
Human neural stem cell cultures provide progenitor cells that are potential cells of origin for brain cancers. However, the extent to which genetic predisposition to tumor formation can be faithfully captured in stem cell lines...
SHH Human pluripotent stem cells Medulloblastoma neuroepithelial stem cells Animals Basal Cell Nevus Syndrome Brain Neoplasms Carcinogenesis DEAD-box RNA Helicases Disease Models Animal Genetic Engineering Genetic Predisposition to Disease Humans Medulloblastoma Mice Mice SCID N-Myc Proto-Oncogene Protein Neoplasm Proteins Neural Stem Cells Neuroepithelial Cells Patched-1 Receptor Pluripotent Stem Cells Stem Cell Transplantation Transplantation Heterologous