Search
Results: 25
Selective stimulation of colonic L cells improves metabolic outcomes in mice
Jo E. Lewis, Emily L. Miedzybrodzka, Rachel E. Foreman, Orla R. M. Woodward, Richard G. Kay, Deborah A. Goldspink, Fiona M. Gribble, Frank Reimann
Jun 10, 2020
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying.
Eleonora Seelig, Elana Henning, Julia M Keogh, Daniel Gillett, Evelyn Shin, John Buscombe, Agatha A van der Klaauw, I Sadaf Farooqi
Oct 25, 2021
OBJECTIVE: People who are severely obese due to melanocortin-4 receptor (MC4R) deficiency experience hyperphagia and impaired fullness after a meal (satiety). Meal-induced satiety is influenced by hormones, such as peptide-YY...
Interrupting Prolonged Sitting with Intermittent Walking Increases Postprandial Gut Hormone Responses
Yung-Chih Chen, Jean-Philippe Walhin, Aaron Hengist, Javier Gonzalez, James Betts, Dylan Thompson
Jul 31, 2022
Introduction Continuous exercise can increase postprandial gut hormone such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) responses, but it is unknown whether interrupting prolonged sitting with intermittent walking...
Glucagon-Like Peptide 1 Glucose-dependent insulinotropic polypeptide Incretin Peptide YY Prolonged sitting Sedentary /dk/atira/pure/subjectarea/asjc/2700/2732 name=Orthopedics and Sports Medicine /dk/atira/pure/subjectarea/asjc/3600/3612 name=Physical Therapy, Sports Therapy and Rehabilitation /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.
Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice.
Ryan A Lafferty, Neil Tanday, R Charlotte Moffett, Frank Reimann, Fiona M Gribble, Peter R Flatt, Nigel Irwin
Jan 29, 2021
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study...
Diabetes Peptide YY sea lamprey PYY streptozotocin transdifferentiation Animals Bacterial Proteins Blood Glucose Cell Differentiation Diabetes mellitus Experimental Glucagon Glucagon-Secreting Cells Insulin Insulin-Secreting Cells Islets of Langerhans Luminescent Proteins Mice Mice Inbred C57BL Neuropeptide Y Peptides Petromyzon Streptozocin Transgenes
Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – identification of selective stimuli for Insulin-like peptide-5 and Glucagonlike peptide-1 co-expressing cells
Frank Reimann, Lawrence Billing, Pierre Larraufie, Jo Lewis, Andrew Leiter, Joyce Li, Brian Lam, Giles Yeo, Deborah Goldspink, Richard Kay, Fiona Gribble
Sep 06, 2019
OBJECTIVE: Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here...
Enteroendocrine Cells Glucagon-like peptide-1 (GLP-1) Insulin-like peptide-5 (INSL5) Serotonin (5-HT) Single cell RNA-sequencing Animals Enteroendocrine Cells Female Glucagon-Like Peptide 1 Insulin Intestine Large Male Mice Mice Inbred C57BL Mice Transgenic Peptide YY Proteins Receptor Angiotensin Type 1 Single-Cell Analysis Transcriptome Tryptophan Hydroxylase
Appetite Control across the Lifecourse
Daniel R Crabtree, William Buosi, Claire L Fyfe, Graham W Horgan, Yannis Manios, Odysseas Androutsos, Angeliki Giannopoulou, Graham Finlayson, Kristine Beaulieu, Claire L Meek, Jens J Holst, Klaske Van Van Norren, Julian G Mercer, Alexandra M Johnstone
Dec 02, 2020
Interrupting Prolonged Sitting with Intermittent Walking Increases Postprandial Gut Hormone Responses
Yung-Chih Chen, Jean-Philippe Walhin, Aaron Hengist, Javier Gonzalez, James Betts, Dylan Thompson
Jul 31, 2022
Introduction Continuous exercise can increase postprandial gut hormone such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) responses, but it is unknown whether interrupting prolonged sitting with intermittent walking...
Glucagon-Like Peptide 1 Glucose-dependent insulinotropic polypeptide Incretin Peptide YY Prolonged sitting Sedentary /dk/atira/pure/subjectarea/asjc/2700/2732 name=Orthopedics and Sports Medicine /dk/atira/pure/subjectarea/asjc/3600/3612 name=Physical Therapy, Sports Therapy and Rehabilitation /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Selective stimulation of colonic L cells improves metabolic outcomes in mice.
Jo E Lewis, Emily L Miedzybrodzka, Rachel E Foreman, Orla RM Woodward, Richard G Kay, Deborah A Goldspink, Fiona M Gribble, Frank Reimann
Mar 04, 2020
Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people.
Joost Overduin, Tinh-Hai Collet, Nenad Medic, Elana Henning, Julia M Keogh, Faye Forsyth, Cheryl Stephenson, Marja W Kanning, Rianne MAJ Ruijschop, I Sadaf Farooqi, Agatha A van der Klaauw
Oct 28, 2016
Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.
Lawrence J Billing, Christopher A Smith, Pierre Larraufie, Deborah A Goldspink, Sam Galvin, Richard G Kay, Jonathan D Howe, Ryan Walker, Mihai Pruna, Leslie Glass, Ramona Pais, Fiona M Gribble, Frank Reimann
Sep 21, 2018
3D-SIM Enteroendocrine Glucagon-like peptide-1 (GLP-1) Human colonic cultures Insulin-like peptide-5 (INSL5) L-cell LC-MS peptideYY (PYY) Animals Cells Cultured Chromatography Liquid Colon Enteroendocrine Cells Gastrointestinal Hormones Glucagon-Like Peptide 1 Humans Insulin Intestinal Secretions Mass Spectrometry Mice Peptide Hormones Peptide YY Primary Cell Culture Proteins Receptors G-Protein-Coupled
Selective stimulation of colonic L cells improves metabolic outcomes in mice
Jo E. Lewis, Emily L. Miedzybrodzka, Rachel E. Foreman, Orla R. M. Woodward, Richard G. Kay, Deborah A. Goldspink, Fiona M. Gribble, Frank Reimann
Apr 27, 2021
Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery.
Geoffrey P Roberts, Richard G Kay, James Howard, Richard H Hardwick, Frank Reimann, Fiona M Gribble
Apr 19, 2018
BACKGROUND: Altered enteroendocrine hormone responses are widely believed to underlie the beneficial effects of bariatric surgery in type 2 diabetes. While elevated postprandial glucagon-like peptide-1 (GLP-1) is considered one...
Bariatric Surgery Roux-en-Y gastric bypass Gastrectomy Glucagon glucagon-like peptide-1 (GLP-1) Hypoglycemia Adult Bariatric Surgery Blood Glucose Case-Control Studies Female Gastrectomy Gastric Bypass Gastric Inhibitory Polypeptide Glucagon Glucagon-Like Peptide 1 Glucose Tolerance Test Humans Hypoglycemia Insulin Male Peptide YY Proglucagon Thinness
SCFAs strongly stimulate PYY production in human enteroendocrine cells.
P Larraufie, C Martin-Gallausiaux, N Lapaque, J Dore, FM Gribble, F Reimann, HM Blottiere
Feb 16, 2018
Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes. PYY production is highest...
Free Fatty Acid Receptors in Enteroendocrine Cells.
Free fatty acid receptors (FFAs) are highly enriched in enteroendocrine cells providing pathways to link dietary fats and microbially generated short-chain fatty acids (SCFAs) to the secretion of a variety of gut hormones. FFA1...
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Rune E Kuhre, Nicolai J Wewer Albrechtsen, Olav Larsen, Sara L Jepsen, Emilie Balk-Møller, Daniel B Andersen, Carolyn F Deacon, Kristina Schoonjans, Frank Reimann, Fiona M Gribble, Reidar Albrechtsen, Bolette Hartmann, Mette M Rosenkilde, Jens J Holst
Jun 05, 2018
OBJECTIVE: Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative importance and mechanisms involved in BA-stimulated...
The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans
Katharina Kessler, Silke Hornemann, Klaus J Petzke, Margrit Kemper, Achim Kramer, Andreas FH Pfeiffer, Olga Pivovarova, Natalia Rudovich
Apr 03, 2019
Diurnal carbohydrate and fat distribution modulates glycaemic control in rodents. In humans, the optimal timing of both macronutrients and its effects on glycaemic control after prolonged consumption are not studied in detail....
Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.
Pierre Larraufie, Geoffrey P Roberts, Anne K McGavigan, Richard G Kay, Joyce Li, Andrew Leiter, Audrey Melvin, Emma K Biggs, Peter Ravn, Kathleen Davy, David C Hornigold, Giles SH Yeo, Richard H Hardwick, Frank Reimann, Fiona M Gribble
Feb 07, 2019
GLP-1 Bariatric Surgery Enteroendocrine Cells gut hormones intestinal transit Mass Spectrometry peptidomics transcriptomics Adult Animals Bariatric Surgery Enteroendocrine Cells Female Glucagon-Like Peptide 1 Glucose Homeostasis Humans Hypoglycemic Agents Insulin Secretion Intestinal Mucosa Male Mice Mice Inbred C57BL Middle Aged obesity Peptide Fragments Peptide YY Postoperative Period Transcriptome
Satiating Effect of High Protein Diets on Resistance-Trained Subjects in Energy Deficit.
Justin Roberts, Anastasia Zinchenko, Krishnaa Mahbubani, James Johnstone, Lee Smith, Viviane Merzbach, Miguel Blacutt, Oscar Banderas, Luis Villasenor, Fredrik T Vårvik, Menno Henselmans
Mar 19, 2019
Short-term energy deficit strategies are practiced by weight class and physique athletes, often involving high protein intakes to maximize satiety and maintain lean mass despite a paucity of research. This study compared the...
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Claudia Guida, Sam D Stephen, Michael Watson, Niall Dempster, Pierre Larraufie, Thomas Marjot, Tamsin Cargill, Lisa Rickers, Michael Pavlides, Jeremy Tomlinson, Jeremy FL Cobbold, Chun-Mei Zhao, Duan Chen, Fiona Gribble, Frank Reimann, Richard Gillies, Bruno Sgromo, Patrik Rorsman, John D Ryan, Reshma D Ramracheya
Feb 04, 2020
BACKGROUND: Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial...
Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state.
BACKGROUND: Gastrointestinal hormones regulate intestinal transit, control digestion, influence appetite and promote satiety. Altered production or action of gut hormones, including glucagon-like peptide-1 (GLP-1)...
Glucagon-like peptide 1 (GLP-1) analytical chemistry Glucose-dependent insulinotropic polypeptide (GIP) Immunoassay peptide YY (PYY) Adolescent Adult Aged Blood Glucose Fasting Female Gastric Inhibitory Polypeptide Gastrointestinal Hormones Glucagon Glucagon-Like Peptide 1 Glucose Tolerance Test Healthy Volunteers Humans Insulin Male Middle Aged obesity Pancreatic Hormones Peptide YY Postprandial Period Reference Values Young Adult
The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents.
Thomas M McGrath, Eleanor Spreckley, Aina Fernandez Rodriguez, Carlo Viscomi, Amin Alamshah, Elina Akalestou, Kevin G Murphy, Nick S Jones
Jan 06, 2020
Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of...
Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion.
Ramona Pais, Juraj Rievaj, Claire Meek, Gayan De Costa, Samanthie Jayamaha, R Todd Alexander, Frank Reimann, Fiona Gribble
Mar 31, 2016
Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.
Van B Lu, Juraj Rievaj, Elisabeth A O'Flaherty, Christopher A Smith, Ramona Pais, Luke A Pattison, Gwen Tolhurst, Andrew B Leiter, David C Bulmer, Fiona M Gribble, Frank Reimann
Feb 12, 2019
Adenosine Triphosphate Afferent Pathways Animals Cell Line Eating Enterocytes Enteroendocrine Cells Female Ganglion Cysts Glucagon-Like Peptide 1 Incretins Intestinal Mucosa Intestines Male Mice Mice Inbred C57BL Neurons Neurons Afferent nodose ganglion Peptide YY Receptors Purinergic P2X2 Receptors Purinergic P2X3 Vagus Nerve
Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice
Ryan A. Lafferty, Neil Tanday, R. Charlotte Moffett, Frank Reimann, Fiona M. Gribble, Peter R. Flatt, Nigel Irwin
Mar 11, 2021
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study...