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Bioorthogonal Decaging Reactions for Targeted Drug Activation.
Bioorthogonal decaging reactions are highly selective transformations which involve the cleavage of a protecting group from a molecule of interest. Decaging reactions can be classified into subgroups depending on the nature of...
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Multicomponent synthesis of tertiary alkylamines by photocatalytic olefin-hydroaminoalkylation.
There is evidence to suggest that increasing the level of saturation (that is, the number of sp3-hybridized carbon atoms) of small molecules can increase their likelihood of success in the drug discovery pipeline1. Owing to...
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Photoelectrochemistry of Photosystem II in Vitro vs in Vivo.
Factors governing the photoelectrochemical output of photosynthetic microorganisms are poorly understood, and energy loss may occur due to inefficient electron transfer (ET) processes. Here, we systematically compare the...
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Photoactivated release of membrane impermeant sulfonates inside cells.
Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a...
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On/off-switchable anti-neoplastic nanoarchitecture.
Throughout the world, there are increasing demands for alternate approaches to advanced cancer therapeutics. Numerous potentially chemotherapeutic compounds are developed every year for clinical trial and some of them are...
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Semi-biological approaches to solar-to-chemical conversion.
This review presents a comprehensive summary of the recent development in semi-artificial photosynthesis, a biological-material hybrid approach to solar-to-chemical conversion that provides new concepts to shape a sustainable...
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Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.
When considering life's aetiology, the first questions that must be addressed are "how?" and "where?" were ostensibly complex molecules, considered necessary for life's beginning, constructed from simpler, more abundant...
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