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A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.
Adriana Ordóñez, Juan Pérez, Lu Tan, Jennifer A Dickens, Neda Motamedi-Shad, James A Irving, Imran Haq, Ugo Ekeowa, Stefan J Marciniak, Elena Miranda, David A Lomas
May 18, 2018
Mutant Z α1-antitrypsin (E342K) accumulates as polymers within the endoplasmic reticulum (ER) of hepatocytes predisposing to liver disease, whereas low levels of circulating Z α1-antitrypsin lead to emphysema by loss of...
Liver Disease Monoclonal antibody scFv intrabody serpin polymer Animals Base Sequence COS Cells Chlorocebus aethiops Endoplasmic Reticulum Humans Immunoblotting Intracellular Space Kinetics Leukocyte Elastase Mice Inbred BALB C Molecular Sequence Data Mutation Polymerization Protease Inhibitors Single-Chain Antibodies alpha 1-Antitrypsin
Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria
Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.
Si Ming Man, Andrew Ekpenyong, Panagiotis Tourlomousis, Sarra Achouri, Eugenia Cammarota, Katherine Hughes, Alessandro Rizzo, Gilbert Ng, John A Wright, Pietro Cicuta, Jochen R Guck, Clare E Bryant
Feb 03, 2015
ASC ROS caspase-1 Cytoskeleton innate immunity Actin Cytoskeleton Actins Animals Apoptosis Regulatory Proteins Bone Marrow Cells Calcium-Binding Proteins Caspase 1 Cytoskeleton Hydrogen Peroxide Immunity Innate Inflammasomes Inflammation Interleukin-1beta MACROPHAGES Mice Mice Transgenic Microscopy Confocal Neutrophils Polymerization Reactive Oxygen Species Salmonella Infections Salmonella typhimurium
Zirconium amine tris(phenolate)
Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization...
Measuring the effects of α1 -antitrypsin polymerisation on the structure and biophysical properties of the endoplasmic reticulum.
An important function of the endoplasmic reticulum (ER) is to serve as a site of secretory protein folding. When the accumulation of misfolded proteins threatens to disturb luminal homoeostasis, the cell is said to experience ER...
Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus.
Devika Ranade, Roopali Pradhan, Muhunden Jayakrishnan, Sushmitha Hegde, Kundan Sengupta
Apr 06, 2020
BACKGROUND: Nuclear lamins are type V intermediate filament proteins that maintain nuclear structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk between the cytoskeleton and the nucleus...
actin Chromosome territories Emerin Lamin A/C Nuclear myosin 1 NUCLEUS Actins Cell Line Tumor Cell Nucleus Chromatin Chromosome Positioning Chromosomes Human Pair 18 Chromosomes Human Pair 19 Cytoskeleton Gene Expression Regulation Neoplastic Gene Knockdown Techniques Genetic Loci Humans Interphase Kallikreins Lamin Type A Membrane Proteins Muscle Proteins Myosin Type I Nuclear Envelope Nuclear Proteins Polymerization Proto-Oncogene Proteins c-bcl-2 RNA Small Interfering Smad2 Protein Transfection
Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.
Lu Tan, Juan Perez, Marianna Mela, Elena Miranda, Keith A Burling, Farshid N Rouhani, Dawn L DeMeo, Imran Haq, James A Irving, Adriana Ordóñez, Jennifer A Dickens, Mark Brantly, Stefan J Marciniak, Graeme JM Alexander, Bibek Gooptu, David A Lomas
May 18, 2018
α1-Antitrypsin is primarily synthesised in the liver, circulates to the lung and protects pulmonary tissues from proteolytic damage. The Z mutant (Glu342Lys) undergoes inactivating conformational change and polymerises. Polymers...
Zinc Complexes for PLA Formation and Chemical Recycling:
A series of Zn II complexes, based on propylenediamine Schiff bases, have been prepared and fully characterized. X-ray crystallography and NMR spectroscopy identified significant differences in the solid and...
alkyl lactate homogeneous catalysis poly(ethylene terephthalate) poly(lactic acid) Polymerization /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2100/2100 name=General Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production
Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.
Claudia Moriconi, Adriana Ordoñez, Giuseppe Lupo, Bibek Gooptu, James A Irving, Rosina Noto, Vincenzo Martorana, Mauro Manno, Valentina Timpano, Noemi A Guadagno, Lucy Dalton, Stefan J Marciniak, David A Lomas, Elena Miranda
May 18, 2018
The neuronal serpin neuroserpin undergoes polymerisation as a consequence of point mutations that alter its conformational stability, leading to a neurodegenerative dementia called familial encephalopathy with neuroserpin...
The effect of high intensity ultrasound on the synthesis of some polyurethanes
High intensity ultrasound has been applied to the preparation of polyurethanes from a number of diisocyanates and diols. In all cases, the sonochemical reactions proceeded faster in the early stages and led to higher molecular...
The effect of high intensity ultrasound on the synthesis of some polyurethanes
High intensity ultrasound has been applied to the preparation of polyurethanes from a number of diisocyanates and diols. In all cases, the sonochemical reactions proceeded faster in the early stages and led to higher molecular...
Molecular Mechanism of Z α1-Antitrypsin Deficiency.
Xin Huang, Ying Zheng, Fei Zhang, Zhenquan Wei, Yugang Wang, Robin W Carrell, Randy J Read, Guo-Qiang Chen, Aiwu Zhou
Feb 12, 2020
The Z mutation (E342K) of α1-antitrypsin (α1-AT), carried by 4% of Northern Europeans, predisposes to early onset of emphysema due to decreased functional α1-AT in the lung and to liver cirrhosis due to accumulation of polymers...
MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
Mei Qi Kwa, Rafael Brandao, Trong H Phung, Jianfeng Ge, Giuseppe Scieri, Cord Brakebusch
Apr 21, 2021
MRCKα is a ubiquitously expressed serine/threonine kinase involved in cell contraction and F-actin turnover, which is highly amplified in human breast cancer and part of a gene expression signature for bad prognosis. Nothing is...
MRCK Breast Cancer invasion Actin Depolymerizing Factors Actins Animals Antigens Neoplasm Antigens Polyomavirus Transforming Base Sequence Carcinogenesis Cell Line Tumor Cell Survival Collagen Disease Models Animal Female Gels Humans Mammary Glands Animal Mammary Neoplasms Animal Mammary Tumor Virus mouse Mice Mice Knockout Mutation Myosins Myotonin-Protein Kinase Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Proteins Phenotype Phosphorylation Polymerization Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Triple Negative Breast Neoplasms
Modular Design of Self-Assembling Peptide-Based Nanotubes.
Natasha C Burgess, Thomas H Sharp, Franziska Thomas, Christopher W Wood, Andrew R Thomson, Nathan R Zaccai, R Leo Brady, Louise C Serpell, Derek N Woolfson
Mar 11, 2016
Amplification of actin polymerization forces.
The actin cytoskeleton drives many essential processes in vivo, using molecular motors and actin assembly as force generators. We discuss here the propagation of forces caused by actin polymerization, highlighting simple...
Visualizing the functional architecture of the endocytic machinery.
Clathrin-mediated endocytosis is an essential process that forms vesicles from the plasma membrane. Although most of the protein components of the endocytic protein machinery have been thoroughly characterized, their...
Zirconium amine tris(phenolate)
Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization...
Zinc Complexes for PLA Formation and Chemical Recycling:
A series of Zn II complexes, based on propylenediamine Schiff bases, have been prepared and fully characterized. X-ray crystallography and NMR spectroscopy identified significant differences in the solid and...
alkyl lactate homogeneous catalysis poly(ethylene terephthalate) poly(lactic acid) Polymerization /dk/atira/pure/subjectarea/asjc/2300/2304 name=Environmental Chemistry /dk/atira/pure/subjectarea/asjc/1500/1500 name=General Chemical Engineering /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2100/2100 name=General Energy /dk/atira/pure/sustainabledevelopmentgoals/decent_work_and_economic_growth name=SDG 8 - Decent Work and Economic Growth /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production