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Results: 191
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern....
Estrogen estrogen receptor MCF7 Breast Cancer Chromosomes Computational Biology endocrine Gene Expression human Systems Biology Base Sequence Binding Sites Estradiol Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genome Human Genome-Wide Association Study Humans MCF-7 Cells Neoplasm Proteins Promoter Regions Genetic Protein Binding Receptors CXCR Signal Transduction Sorting Nexins Trefoil Factor-1
Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition.
Clara Lopes Novo, Biola-Maria Javierre, Jonathan Cairns, Anne Segonds-Pichon, Steven W Wingett, Paula Freire-Pritchett, Mayra Furlan-Magaril, Stefan Schoenfelder, Peter Fraser, Peter J Rugg-Gunn
May 10, 2018
chromatin looping DIFFERENTIATION epigenetics Gene regulation genome organization Pluripotency promoter capture Hi-C Animals Cell Differentiation Enhancer Elements Genetic Gene Regulatory Networks Germ Layers Mice Mouse embryonic stem cells Nanog Homeobox Protein Pluripotent Stem Cells Promoter Regions Genetic Protein Binding
CyanoGate
Ravendran Vasudevan, Grant AR Gale, Alejandra A Schiavon, Anton Puzorjov, John Malin, Michael D Gillespie, Konstantinos Vavitsas, Valentin Zulkower, Baojun Wang, Christopher J Howe, David J Lea-Smith, Alistair J McCormick
Mar 14, 2019
Recent advances in synthetic biology research have been underpinned by an exponential increase in available genomic information and a proliferation of advanced DNA assembly tools. The adoption of plasmid vector assembly...
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Amit Sud, Hauke Thomsen, Giulia Orlando, Asta Försti, Philip J Law, Peter Broderick, Rosie Cooke, Fadi Hariri, Tomi Pastinen, Douglas F Easton, Paul DP Pharoah, Alison M Dunning, Julian Peto, Federico Canzian, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Daniele Campa, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Elke Pogge von Strandmann, Anthony J Swerdlow, Andreas Engert, Nick Orr, Kari Hemminki, Richard S Houlston
Nov 21, 2018
Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.
Ewan M Harrison, Xiaoliang Ba, Francesc Coll, Beth Blane, Olivier Restif, Henry Carvell, Claudio U Köser, Dorota Jamrozy, Sandra Reuter, Andrew Lovering, Nicholas Gleadall, Katherine L Bellis, Anne-Catrin Uhlemann, Franklin D Lowy, Ruth C Massey, Inês R Grilo, Rita Sobral, Jesper Larsen, Anders Rhod Larsen, Carina Vingsbo Lundberg, Julian Parkhill, Gavin K Paterson, Matthew TG Holden, Sharon J Peacock, Mark A Holmes
May 03, 2019
Amino Acid Substitution Animals Anti-Bacterial Agents Bacterial Proteins Clavulanic Acid Drug Therapy Combination Methicillin-Resistant Staphylococcus aureus Mice Microbial Sensitivity Tests Moths Mutation Penicillin-Binding Proteins Penicillins Promoter Regions Genetic Staphylococcal Infections beta-Lactam Resistance beta-Lactamase Inhibitors
Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
Jul 31, 2018
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has...
Adult B-Lymphocytes Cell Transformation Viral Cells Cultured Epstein-Barr Virus Infections Female Gene Expression Regulation Viral Genome Viral HEK293 Cells Herpesvirus 4 Human Humans Infant Newborn Leukemia B-Cell Pregnancy Promoter Regions Genetic Protein Binding Transcription Factors Viral Proteins
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
Steven D Mason, Richard A Howlett, Matthew J Kim, I Mark Olfert, Michael C Hogan, Wayne McNulty, Reed P Hickey, Peter D Wagner, C Ronald Kahn, Frank J Giordano, Randall S Johnson
Mar 13, 2020
The physiological flux of oxygen is extreme in exercising skeletal muscle. Hypoxia is thus a critical parameter in muscle function, influencing production of ATP, utilization of energy-producing substrates, and manufacture of...
Adenosine Triphosphate Alleles Animals creatine kinase Crosses Genetic Gene Deletion Gene Expression Regulation Genotype Glucose Glycogen Glycolysis Hematocrit Hemoglobins Hypoxia Hypoxia-Inducible Factor 1 alpha Subunit Lactic Acid Male Mice Mice Inbred C57BL Mice Knockout Microscopy Electron Muscle Skeletal Oxygen Physical Conditioning Animal Physical Exertion Polymerase Chain Reaction Promoter Regions Genetic Reverse Transcriptase Polymerase Chain Reaction
Mutation of the cytosolic ribosomal protein-encoding RPS10B gene affects shoot meristematic function in Arabidopsis.
Arabidopsis Arabidopsis Proteins Cytosol DNA Complementary F-Box Proteins Gene Expression Regulation Plant Genes Plant Indoleacetic Acids Inflorescence Meristem Mutation Naphthaleneacetic Acids Phenotype Plant Leaves Plant Shoots Promoter Regions Genetic Protein Interaction Mapping Receptors Cell Surface Ribosomal Proteins Transcription Factors
A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.
Walfred WC Tang, Sabine Dietmann, Naoko Irie, Harry G Leitch, Vasileios I Floros, Charles R Bradshaw, Jamie A Hackett, Patrick F Chinnery, M Azim Surani
Jun 04, 2015
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Maya Ghoussaini, Juliet D French, Kyriaki Michailidou, Silje Nord, Jonathan Beesley, Sander Canisus, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Mahdi Moradi Marjaneh, Jason S Lee, Joe Dennis, Manjeet K Bolla, Qin Wang, Ed Dicks, Roger L Milne, John L Hopper, Melissa C Southey, Marjanka K Schmidt, Annegien Broeks, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann, Olivia Fletcher, Nichola Johnson, Elinor J Sawyer, Ian Tomlinson, Barbara Burwinkel, Frederik Marme, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Henrik Flyger, Javier Benitez, Anna González-Neira, M Rosario Alonso, Guillermo Pita, Susan L Neuhausen, Hoda Anton-Culver, Hermann Brenner, Volker Arndt, Alfons Meindl, Rita K Schmutzler, Hiltrud Brauch, Ute Hamann, Daniel C Tessier, Daniel Vincent, Heli Nevanlinna, Sofia Khan, Keitaro Matsuo, Hidemi Ito, Thilo Dörk, Natalia V Bogdanova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli-Matti Kosma, kConFab/AOCS Investigators, Anna H Wu, David Van Den Berg, Diether Lambrechts, Giuseppe Floris, Jenny Chang-Claude, Anja Rudolph, Paolo Radice, Monica Barile, Fergus J Couch, Emily Hallberg, Graham G Giles, Christopher A Haiman, Loic Le Marchand, Mark S Goldberg, Soo H Teo, Cheng Har Yip, Anne-Lise Borresen-Dale, NBCS Collaborators, Wei Zheng, Qiuyin Cai, Robert Winqvist, Katri Pylkäs, Irene L Andrulis, Peter Devilee, Rob AEM Tollenaar, Montserrat García-Closas, Jonine Figueroa, Per Hall, Kamila Czene, Judith S Brand, Hatef Darabi, Mikael Eriksson, Maartje J Hooning, Linetta B Koppert, Jingmei Li, Xiao-Ou Shu, Ying Zheng, Angela Cox, Simon S Cross, Mitul Shah, Valerie Rhenius, Ji-Yeob Choi, Daehee Kang, Mikael Hartman, Kee Seng Chia, Maria Kabisch, Diana Torres, Craig Luccarini, Don M Conroy, Anna Jakubowska, Jan Lubinski, Suleeporn Sangrajrang, Paul Brennan, Curtis Olswold, Susan Slager, Chen-Yang Shen, Ming-Feng Hou, Anthony Swerdlow, Minouk J Schoemaker, Jacques Simard, Paul DP Pharoah, Vessela Kristensen, Georgia Chenevix-Trench, Douglas F Easton, Alison M Dunning, Stacey L Edwards
Sep 07, 2016
Alleles Breast Neoplasms Case-Control Studies Cell Line Tumor Chromosomes Human Pair 5 Enhancer Elements Genetic Fibroblast Growth Factor 10 Genetic Predisposition to Disease Haplotypes Humans Polymorphism Single Nucleotide Promoter Regions Genetic Quantitative Trait Loci Receptor Fibroblast Growth Factor Type 2 Receptors Estrogen
Germline TERT promoter mutations are rare in familial melanoma.
Mark Harland, Mia Petljak, Carla Daniela Robles-Espinoza, Zhihao Ding, Nelleke A Gruis, Remco van Doorn, Karen A Pooley, Alison M Dunning, Lauren G Aoude, Karin AW Wadt, Anne-Marie Gerdes, Kevin M Brown, Nicholas K Hayward, Julia A Newton-Bishop, David J Adams, D Timothy Bishop
Oct 07, 2015
Cheryl QE Lee, Lucy Gardner, Margherita Turco, Nancy Zhao, Matthew J Murray, Nicholas Coleman, Janet Rossant, Myriam Hemberger, Ashley Moffett
Jan 14, 2016
Biomarkers Cells Cultured Chromosomes Human Pair 19 DNA Methylation DNA-Binding Proteins Female Fibroblast Growth Factors Histocompatibility Antigens Class I Human Embryonic Stem Cells Humans MicroRNAs Pregnancy Pregnancy Trimester First Promoter Regions Genetic Proto-Oncogene Proteins c-ets Pyrimidines Terminology as Topic Transcription Factors Trophoblasts
SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells.
Alena Pance, Frank R Morrissey-Wettey, Helen Craig, Alison Downing, Richard Talbot, Antony P Jackson
Jan 15, 2016
Animals Apoptosis Cell Line Cell Survival Chemokine CXCL12 Chickens Clathrin Heavy Chains Culture Media Gene Expression Profiling Gene Expression Regulation Iron Deficiencies Oligonucleotide Array Sequence Analysis Precursor Cells B-Lymphoid Promoter Regions Genetic Receptors CXCR4 Signal Transduction Tetracycline Transferrin
Modification of a Constitutive to Glucose-Responsive Liver-Specific Promoter Resulted in Increased Efficacy of Adeno-Associated Virus Serotype 8-Insulin Gene Therapy of Diabetic Mice.
We have previously used a hepatotropic adeno-associated viral (AAV) vector with a modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) used was constitutively active and non-responsive to...
adeno-associated virus serotype 8 (AAV8) albumin enhancer (3′iALB) diabetes gene therapy glucose responsive element (GlRE) liver-specific glucose-responsive promoter long-term basal insulin expression Animals Dependovirus Diabetes mellitus Experimental Disease Models Animal Gene Expression Genetic Therapy Genetic Vectors Glucose Hepatocytes Humans Insulin Mice Promoter Regions Genetic Transgenes
Distinctive regulatory architectures of germline-active and somatic genes in C. elegans.
Jacques Serizay, Yan Dong, Jürgen Jänes, Michael Chesney, Chiara Cerrato, Julie Ahringer
Jan 18, 2021
RNA profiling has provided increasingly detailed knowledge of gene expression patterns, yet the different regulatory architectures that drive them are not well understood. To address this, we profiled and compared...
The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W Wingett, Peter Fraser
Jul 29, 2021
BACKGROUND: Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under...
Chromatin compartments Circadian gene expression circadian rhythms Enhancers Genome 3D organization Promoter interactions TADs Transcription regulation Animals Base Sequence Biological Clocks Chromatin Circadian Rhythm Enhancer Elements Genetic Gene Expression Regulation Genome Liver Male Mice Inbred C57BL Models Genetic Promoter Regions Genetic Time Factors Transcription Genetic
The importance of DNA methylation in prostate cancer development.
Maternal diet, aging and diabetes meet at a chromatin loop.
Physical constraints determine the logic of bacterial promoter
architectures
Site-specific transcription factors (TFs) bind to their target sites on the
DNA, where they regulate the rate at which genes are transcribed. Bacterial TFs
undergo facilitated diffusion (a combination of 3D diffusion around and...
Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers.
Ana-Teresa Maia, Antonis C Antoniou, Martin O'Reilly, Shamith Samarajiwa, Mark Dunning, Christiana Kartsonaki, Suet-Feung Chin, Christina N Curtis, Lesley McGuffog, Susan M Domchek, EMBRACE, Douglas F Easton, Susan Peock, Debra Frost, D Gareth Evans, Ros Eeles, Louise Izatt, Julian Adlard, Diana Eccles, GEMO Study Collaborators, Olga M Sinilnikova, Sylvie Mazoyer, Dominique Stoppa-Lyonnet, Marion Gauthier-Villars, Laurence Faivre, Laurence Venat-Bouvet, Capucine Delnatte, Heli Nevanlinna, Fergus J Couch, Andrew K Godwin, Maria Adelaide Caligo, SWE-BRCA, Rosa B Barkardottir, kConFab Investigators, Xiaoqing Chen, Jonathan Beesley, Sue Healey, Carlos Caldas, Georgia Chenevix-Trench, Bruce AJ Ponder
May 17, 2012
A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number
Dan J Woodcock, Keith W Vance, Michal Komorowski, Georgy Koentges, Bärbel Finkenstädt, David A Rand
Jun 15, 2013
MOTIVATION: cis-regulatory DNA sequence elements, such as enhancers and silencers, function to control the spatial and temporal expression of their target genes. Although the overall levels of gene expression in large cell...
Functions of the 5' and 3' ends of calicivirus genomes.
Caliciviruses Norovirus RNA secondary structures RNA–protein interactions 3' Untranslated Regions 5' Untranslated Regions Animals Caliciviridae Conserved Sequence Genome Viral Host-Pathogen Interactions Humans Models Biological Nucleic Acid Conformation Promoter Regions Genetic RNA Viral Transcription Genetic Virus Replication
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.
Christopher A Odhams, Amy L Roberts, Susan K Vester, Carolina ST Duarte, Charlie T Beales, Alexander J Clarke, Sonja Lindinger, Samuel J Daffern, Antonino Zito, Lingyan Chen, Leonardo L Jones, Lora Boteva, David L Morris, Kerrin S Small, Michelle MA Fernando, Deborah S Cunninghame Graham, Timothy J Vyse
Sep 18, 2019
Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN)-regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in...
3' Untranslated Regions Adult Age Factors Case-Control Studies Chromosomes Human X Female Genes X-Linked Genetic Predisposition to Disease Humans Interferon Type I Intracellular Signaling Peptides and Proteins Lupus Erythematosus Systemic Male Promoter Regions Genetic Sex Factors Toll-Like Receptor 7
Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells.
Irene Hernando-Herraez, Brendan Evano, Thomas Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen Clark, Simon Andrews, Shahragim Tajbakhsh, Wolf Reik
Nov 26, 2019
Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.
Liane Dupont, Lily Du, Madeleine Poulter, Stephanie Choi, Megan McIntosh, Matthew B Reeves
Feb 25, 2021
Human cytomegalovirus (HCMV) latency and reactivation rely on a complex interplay between cellular differentiation, cell signaling pathways, and viral gene functions. HCMV reactivation in dendritic cells (DCs) is triggered by...
Cell Signaling chromatin modification cytomegalovirus reactivation epigenetic regulation Gene Expression hematopoietic cell kinase herpesvirus histone acetylation lysine acetyltransferase 6A (KAT6A) Phosphoproteomics Cells Cultured Cytomegalovirus Histone Acetyltransferases Humans Promoter Regions Genetic Virus Activation Zinc Fingers src-Family Kinases
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